Earlier quoted context omitted.
Maybe the coolest (heh) application of Cherenkov radiation is neutrino telescopes like IceCube, detecting tiny flashes of light in cubic kilometers of ultra-clear Antarctic ice, caused by vanishingly rare interactions between neutrinos and ordinary matter – and to exclude non-neutrino interactions, they look down , using the entire Earth as a shield guaranteed to stop anything that’s not a neutrino!
While I knew that IceCube existed it didn't occur to me until know that I have no idea how they filter out collisions from particles that comes from above or sideways. Is the resulting flash of light not omnidirectional? Is it polarized differently?
That directionality is very useful. The directionality of a muon or electron produced from a neutrino interaction is correlated with the direction of the incident neutrino. That's interesting for the astrophysical kind of questions that IceCube is addressing, and it's also useful in other contexts (background rejection for fundamental physics searches, monitoring of nuclear reactors via neutrinos, ...).
Cherenkov radiation is indeed polarized, but to my knowledge that hasn't ever been made use of.
Tangentially: there's also some really cool work being done on detectors which utilize both Cherenkov and scintillation light at the same time, exploiting the directional (and other) differences to extract the most information possible out of each event.