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AlphaGenome Atlas: a high-resolution map of human DNA

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Re: AlphaGenome Atlas: a high-resolution map of human DNA

#61

Post by DoctorOetker »

Not a word about promoter sequences.

Imagine cellular activity as an industry zone, its not just what you can or can not make, its also 'for what concentrations of chemical species, what transcription rates should be used' so apart from the discrete Mendelian aspects (like what eye color or what have you) there is also a concensus sequence and deviations from consensus. They mention the dataset captures non-coding DNA, which should imply promoter sequences. Will it be possible to query the atlas for joint probabilities of promoter and putative target protein occurence in human genomes?

Personalized medicine could never credibly take off as long as promoter sequences were excised before sequencing!

Re: AlphaGenome Atlas: a high-resolution map of human DNA

#62

Post by dekhn »

mchusma wrote: post #50

This has Demis written all over it. There is a great video of him with AlphaFold chatting with the team about releasing some results, and he asked something like “what if we just do them all?” Very excited to see that happen here.

This has nothing to do with AlphaFold at all- not sure if you were implying that. (the scientific contriution is welcome, but it's not particularly significant)

Re: AlphaGenome Atlas: a high-resolution map of human DNA

#63

Post by rightnutwingjob »

surgical_fire wrote: post #54
godwinson__4-8 wrote: post #47

Earlier quoted context omitted.

Market reward is the best proxy for good we have. What's your alternative? Executive fiat? Mob rule? Deepmind is objectively good. These endeavors would always cost money. Better private capital than state, no one has to give Google anything. The state is not so generous.

> Market reward is the best proxy for good we have. Only if the goal is profit. All else be damned. > What's your alternative? Executive fiat? Mob rule? It is always bewildering to me that people see the world being raped by corporations and their negative externality, and they think that this is the pinnacle that humanity can achieve. Nothing else can be better, if all your options are "mob rule" or "executive fiat"…

[flagged]

Re: AlphaGenome Atlas: a high-resolution map of human DNA

#64

Post by dekhn »

shevy-java wrote: post #59
dekhn wrote: post #41

Earlier quoted context omitted.

Not really, no.

Why not? There is no logical reason as to why this would not work, IF it works in the first place, which I don't know. In theory the problem space here is finite, so there is of course a way to predict everything. Whether this is the case right now - who knows; I probably don't think it is currently ready. But eventually it will be. And it should not be in the hands of private companies.

So it sounds like you're coming to this with very little knowledge about biology. I encourage reading up on modern challenges in pathogenic prediction, especially with regards to SNPs: on their own, with the exception of a few diseases, individual SNP predictions are meaningless in terms of actual pathogenicity.

Re: AlphaGenome Atlas: a high-resolution map of human DNA

#65

Post by MisterMunchkin »

RobotToaster wrote: post #36

Can this be used with a 23andMe genome to find pathogenic mutations?

23andMe and similar companies don't transcribe your entire genome because that would cost way more than they charge you. They just sample a few tiny sections of it.

Re: AlphaGenome Atlas: a high-resolution map of human DNA

#66

Post by Exoristos »

godwinson__4-8 wrote: post #47
surgical_fire wrote: post #45

Earlier quoted context omitted.

If Google does anything good for the world it is entirely accidental, and I am certain they will correct this mistake later.

Market reward is the best proxy for good we have. What's your alternative? Executive fiat? Mob rule? Deepmind is objectively good. These endeavors would always cost money. Better private capital than state, no one has to give Google anything. The state is not so generous.

Executive fiat, given the right executive body, and undergirded by healthy autarkies or other cell-type self-direction, worked well in most locales for most of the years humans have been humans. Certain flashy civilizations, Sumer, Greece, have tended to draw the spotlight incommensurately with their population sizes. But even these functioned much more like what I describe above than anything modern.

Re: AlphaGenome Atlas: a high-resolution map of human DNA

#67

Post by picofarad »

rightnutwingjob wrote: post #63
surgical_fire wrote: post #54

Earlier quoted context omitted.

> Market reward is the best proxy for good we have. Only if the goal is profit. All else be damned. > What's your alternative? Executive fiat? Mob rule? It is always bewildering to me that people see the world being raped by corporations and their negative externality, and they think that this is the pinnacle that humanity can achieve. Nothing else can be better, if all your options are "mob rule" or "executive fiat"…

[flagged]

Misanthrope doesn't mean "wants people to be dead" what a wild thing to say

Re: AlphaGenome Atlas: a high-resolution map of human DNA

#68

Post by lorepieri »

minimeow wrote: post #42
boelboel wrote: post #39

Earlier quoted context omitted.

Google Streetview/maps isn't even the best mapping/'streetview' tool at this point. Filled with ads and bugs, some major bugs have been there for 10+ years.

Now I'm curious. What is the better mapping and streetview tool at this point?

Organic Maps for maps

Re: AlphaGenome Atlas: a high-resolution map of human DNA

#69

Post by nimonian »

I am freaking out. This is a huge moment.

I don't want to drag the discourse away from this achievement, but I hate how this is announced with blatant corporate advertising (our internal model, here are the benchmarks, gpt astra TM yours now for the low low price of £200pcm). I just didn't think Navier-Stokes falling would be sponsored by McDonald's.

Still. I am crying right now. Navier-Stokes is solved.

Re: AlphaGenome Atlas: a high-resolution map of human DNA

#70

Post by rightnutwingjob »

picofarad wrote: post #67
rightnutwingjob wrote: post #63

Earlier quoted context omitted.

[flagged]

Misanthrope doesn't mean "wants people to be dead" what a wild thing to say

It does in practice.

Try talking to a misanthrope.

You’ll quickly learn that humanity sucks and “the planet” would be better off without us. And the sooner the better.

Go, survey the field.

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