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GLP-1s are being linked to fewer serious infections, including TB

gizmodo.com

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Re: GLP-1s are being linked to fewer serious infections, including TB

#81

Post by OptionOfT »

joshstrange wrote: post #78

Question for people using GLP-1s: Do you plan to stay on them indefinitely? Are you concerned about gaining back the weight if you ever stop taking them? I've had success with weight loss through diet and exercise (exclusive and inclusive at different points) but had trouble keeping it off. GLP-1s are attractive for sure but I cannot make up my mind on if it's worth the risks (both known and unknown). I know everythi…

Yes.

I hike 5 miles a day, I ate super-healthy (no ultra-processed foods, cook at home every day etc), only drink water, coffee & tea. Actually rarely eat stuff which has added sugar on the package, and avoid foods that have > 5 ingredients (more means it's too processed for me). I bake my own bread (sourdough, salt, flour, water, maybe home-grown japalenos).

And yet, I kept on gaining weight...

My problem is don't get the signal that I'm full fast enough. I have tried _everything_. Drink 2 glasses of water, fibers, eat slower, smaller plates, dietician, track calories.

They work in isolation, but I always end up hungry. Compare it to alcohol. The desire to drink. The solution there is easy. No more alcohol, and that works for most people.

With food? Can't completely abstain...

Went on GLP-1, worked great. Because of hip surgery had to stop for a while, and the weight just came back, because naturally, you revert to your old eating habits, as you chase the signal of satiation.

Now back on them and I'll be on it until the day I die. I pay $450 a month for now because insurance doesn't think I am fat enough now (I'm not). They expect me to go back to my overweight weight..., and even then, acceptance is not guaranteed.

In terms of risks: If I don't take it I'll wear out my knees sooner (hips were related to genetics, not weight). If I don't take it I need 1h more / sleep every night, I have sleep apnea, higher blood pressure, higher cholesterol (doesn't mater how healthy EVOO is, if you eat a huge salad you'll eat a lot of oil).

It's not a risk of GLP-1 against nothing. It's GLP-1 risks vs heart-disease/etc.

At least with GLP-1 I get to live now.

Re: GLP-1s are being linked to fewer serious infections, including TB

#82

Post by clickety_clack »

jawilson2 wrote: post #76
clickety_clack wrote: post #42

Earlier quoted context omitted.

By its fundamental design, an observational study cannot account for everything. That is the critique and it is a valid one.

This was published in Nature, I'm pretty sure the reviewers understand and account for that. HN and reasonably educated people always think this is some huge gotcha, second only to "CORRELATION != CAUSATION!!!!"

Nature isn't an arbiter of truth, it's a publisher of papers. It's also meant to be read critically by people who see a paper like this and and think "interesting, but this is just an observational study, I'd like to see more research, maybe something with more controls before I believe this".

Say what you want about the "correlation doesn't imply causation", but many people do not understand why that is. As a shorthand for "hey, you don't know the statistics behind this, so don't take the pretty picture at face value", it's pretty good.

Re: GLP-1s are being linked to fewer serious infections, including TB

#83

Post by what-the-grump »

joshstrange wrote: post #78

Question for people using GLP-1s: Do you plan to stay on them indefinitely? Are you concerned about gaining back the weight if you ever stop taking them? I've had success with weight loss through diet and exercise (exclusive and inclusive at different points) but had trouble keeping it off. GLP-1s are attractive for sure but I cannot make up my mind on if it's worth the risks (both known and unknown). I know everythi…

They cured my migraines, dose small enough to be stable weight. But I have my life back, I get tired instead of getting migraines now.

Half the smallest dose, keeps my headaches away for 2-3 weeks. My food intake simply changed, I got used to eating less / healthier.

Re: GLP-1s are being linked to fewer serious infections, including TB

#85

Post by throw-qqqqq »

scheme271 wrote: post #38

Could be due to better control of blood sugar. E.g. lower blood sugar increases inflammation, decrease immune response and provides bacteria a readily available source of food.

> lower blood sugar increases inflammation

This is backwards. I think you mean HIGHER blood sugar, right?

Re: GLP-1s are being linked to fewer serious infections, including TB

#86

Post by joshstrange »

OptionOfT wrote: post #81
joshstrange wrote: post #78

Question for people using GLP-1s: Do you plan to stay on them indefinitely? Are you concerned about gaining back the weight if you ever stop taking them? I've had success with weight loss through diet and exercise (exclusive and inclusive at different points) but had trouble keeping it off. GLP-1s are attractive for sure but I cannot make up my mind on if it's worth the risks (both known and unknown). I know everythi…

Yes. I hike 5 miles a day, I ate super-healthy (no ultra-processed foods, cook at home every day etc), only drink water, coffee & tea. Actually rarely eat stuff which has added sugar on the package, and avoid foods that have > 5 ingredients (more means it's too processed for me). I bake my own bread (sourdough, salt, flour, water, maybe home-grown japalenos). And yet, I kept on gaining weight... My problem is don't g…

Thank you, I really appreciate your response.

Re: GLP-1s are being linked to fewer serious infections, including TB

#87

Post by antinomicus »

TehCorwiz wrote: post #26
tarxvf wrote: post #4

How expensive are GLP-1s again?

I self pay for one from lilly-direct for about $200/mo. Insurance doesn't cover any part of it yet. It required a prescription from my doc and it comes in the mail.

Only 200$? That’s way less than they charge me!

Re: GLP-1s are being linked to fewer serious infections, including TB

#88

Post by throw-qqqqq »

throw-qqqqq wrote: post #84
bayareabadboy wrote: post #48

Maybe being overweight is bad for the immune system

It is well known that you have higher levels of inflammation if overweight, which generally worsens your immune response.

I see I got downvoted. This is well established and not controversial at all. Lots of research supports it.

From https://pmc.ncbi.nlm.nih.gov/articles/PMC4791086/

> There is strong evidence indicating that excess adiposity negatively impacts immune function and host defence in obese individuals.

Adipose tissue is body fat.

More references:

- https://www.sciencedirect.com/science/article/pii/S216183132...

- https://www.mdpi.com/2075-1729/14/7/856

- https://pmc.ncbi.nlm.nih.gov/articles/PMC296995/

I suggest discussing it with your favorite AI if you doubt it ¯\_(ツ)_/¯

Re: GLP-1s are being linked to fewer serious infections, including TB

#89

Post by monster_truck »

owebmaster wrote: post #66
monster_truck wrote: post #65

Earlier quoted context omitted.

huge if true

That's a known fact. That's why the first thing doctors say to overweight people is to lose weight for pretty much any disease. Some get hurt and blame the doctors, which doesn't help them.

So, "Huge if true" is a meme based on "journalism"

Re: GLP-1s are being linked to fewer serious infections, including TB

#90

Post by inglor_cz »

faangguyindia wrote: post #77
inglor_cz wrote: post #59

Earlier quoted context omitted.

"GLP medications blunt your appetite so you eat less, but you still end up feeling completely drained because your body lacks fuel." How many people report that? Not that many, AFAIK. "GLP drugs cannot distinguish between nutrient-dense meals and the junk food binges you are trying to avoid." This again goes against what people report - aversion to junk food so strong that McDonalds et al. consider this a potential t…

If GLPs were that effective, why would these people need such a guide? https://www.reddit.com/r/tirzepatidecompound/comments/1omfgx...

Bodybuilding it quite an unnatural activity in itself, and the practitioners try to achieve levels of fat that are basically unseen in normal Homo sapiens.
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