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GLP-1s are being linked to fewer serious infections, including TB

gizmodo.com

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Re: GLP-1s are being linked to fewer serious infections, including TB

#31

Post by tptacek »

bitwize wrote: post #29
olalonde wrote: post #25

Earlier quoted context omitted.

Many of the health benefits, including cardiovascular and kidney health, have been shown to go beyond or be unrelated to changes in body weight. https://www.youtube.com/watch?v=yKPaVhpomks

Lower visceral fat as a percentage of body weight may bring benefits that are greater than proportional to total body mass lost.

Nobody's denying this, but the interesting story about GLP-1s is that after you control for fat loss (for instance, by taking cohorts of patients that aren't losing weight) you still get evidence of these off-target effects.

Re: GLP-1s are being linked to fewer serious infections, including TB

#33

Post by david-gpu »

gavinray wrote: post #23
tarxvf wrote: post #4

How expensive are GLP-1s again?

How technical do you want to get? The grey-market price from China, is about $100 for 10 x (30mg/mL, 10mL) vials of Tirzepatide. Semaglutide is cheaper. At the highest dose of 15mg/wk, that's 20 weeks for $100.

Are you sure that it is not 30mg total per vial, with $100 being the price for 10 vials? Because this stuff comes in powder form, not in liquid form, so mg/mL is an odd unit of measurement. Perhaps I misunderstand your comment.

Re: GLP-1s are being linked to fewer serious infections, including TB

#34

Post by DANmode »

maxall4 wrote: post #22
master_crab wrote: post #2

Using a large database of (deidentified) medical records, the researchers compared the outcomes of people taking a GLP-1 for their type 2 diabetes to people taking other common diabetes drugs between 2017 and 2025. GLP-1 users were significantly less likely to be diagnosed with TB for up to a five-year span, they found. Both of these studies are observational and retrospective, meaning they can only show a correlatio…

The benefit is probably from the removal of fat, not a direct antibacterial/antiviral effect. Fat plays a complex immunoregulatory role in human physiology: it down-regulates some pathways, while up-regulating others (notoriously, the production of IL6 is carried out, in part, by adipocytes). The overall effect of fat on the immune system, however, is negative: it tends to increase the chances of rheumatological diso…

How much of “fat” also includes biofilmed infection stifling your electrical system and indeed signaling your immune system to not work as well?

(You can look this up regarding biofilms, I just did today.)

Re: GLP-1s are being linked to fewer serious infections, including TB

#40

Post by k12sosse »

Scoundreller wrote: post #21
k12sosse wrote: post #17

Earlier quoted context omitted.

Canada has generic semiglutide for under/around $300/mo depending on pharmacy

More like CAD$90 for a 4mg pen

I think you're right I confused wegovy prices with generics. Thank you for clarifying. I'm new to it and will find out about pricing very soon - my provider dropped covering the medication (the day I submitted for pre-approval) -because it worked so well it became popular :P
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