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GLP-1s are being linked to fewer serious infections, including TB

gizmodo.com

21–30 of 87 posts

Re: GLP-1s are being linked to fewer serious infections, including TB

#21

Earlier quoted context omitted.

> GLP-1 receptor agonist medications typically cost between $149 and $350 per month for cash-pay oral pills, and $900 to $1,400+ per month for list-price injectables without insurance.

Canada has generic semiglutide for under/around $300/mo depending on pharmacy

More like CAD$90 for a 4mg pen

Re: GLP-1s are being linked to fewer serious infections, including TB

#22

Using a large database of (deidentified) medical records, the researchers compared the outcomes of people taking a GLP-1 for their type 2 diabetes to people taking other common diabetes drugs between 2017 and 2025. GLP-1 users were significantly less likely to be diagnosed with TB for up to a five-year span, they found. Both of these studies are observational and retrospective, meaning they can only show a correlatio…

The benefit is probably from the removal of fat, not a direct antibacterial/antiviral effect. Fat plays a complex immunoregulatory role in human physiology: it down-regulates some pathways, while up-regulating others (notoriously, the production of IL6 is carried out, in part, by adipocytes). The overall effect of fat on the immune system, however, is negative: it tends to increase the chances of rheumatological disorders, cancers, and many other diseases. Alternatively, the effect may be due to some sociological factor that their analysis failed to account for.

(I am not a medical doctor)

Re: GLP-1s are being linked to fewer serious infections, including TB

#23
post #4

How expensive are GLP-1s again?

How technical do you want to get?

The grey-market price from China, is about $100 for 10 x (30mg/mL, 10mL) vials of Tirzepatide. Semaglutide is cheaper.

At the highest dose of 15mg/wk, that's 20 weeks for $100.

Re: GLP-1s are being linked to fewer serious infections, including TB

#24
post #15

Earlier quoted context omitted.

Generally studies showing off-target effects with GLP1s are at least attempting to control for this.

I’d be interested to see the data for that claim, since I would imagine a strong correlation between glp use and lower body fat.

I’m sure you can just look up the studies, but note that GLP1s are widely prescribed to people without weight issues —— weight loss itself was originally an off-target effect. I have friends who run marathons who are on semaglutide.

Re: GLP-1s are being linked to fewer serious infections, including TB

#25
post #22

Using a large database of (deidentified) medical records, the researchers compared the outcomes of people taking a GLP-1 for their type 2 diabetes to people taking other common diabetes drugs between 2017 and 2025. GLP-1 users were significantly less likely to be diagnosed with TB for up to a five-year span, they found. Both of these studies are observational and retrospective, meaning they can only show a correlatio…

The benefit is probably from the removal of fat, not a direct antibacterial/antiviral effect. Fat plays a complex immunoregulatory role in human physiology: it down-regulates some pathways, while up-regulating others (notoriously, the production of IL6 is carried out, in part, by adipocytes). The overall effect of fat on the immune system, however, is negative: it tends to increase the chances of rheumatological diso…

Many of the health benefits, including cardiovascular and kidney health, have been shown to go beyond or be unrelated to changes in body weight.

https://www.youtube.com/watch?v=yKPaVhpomks

Re: GLP-1s are being linked to fewer serious infections, including TB

#27
post #15

Earlier quoted context omitted.

Generally studies showing off-target effects with GLP1s are at least attempting to control for this.

I’d be interested to see the data for that claim, since I would imagine a strong correlation between glp use and lower body fat.

This video by a medical doctor cites many studies showing that GLP-1 health benefits go beyond weight loss (see video description for link to papers): https://www.youtube.com/watch?v=yKPaVhpomks

Re: GLP-1s are being linked to fewer serious infections, including TB

#29
post #22

Earlier quoted context omitted.

The benefit is probably from the removal of fat, not a direct antibacterial/antiviral effect. Fat plays a complex immunoregulatory role in human physiology: it down-regulates some pathways, while up-regulating others (notoriously, the production of IL6 is carried out, in part, by adipocytes). The overall effect of fat on the immune system, however, is negative: it tends to increase the chances of rheumatological diso…

Many of the health benefits, including cardiovascular and kidney health, have been shown to go beyond or be unrelated to changes in body weight. https://www.youtube.com/watch?v=yKPaVhpomks

Lower visceral fat as a percentage of body weight may bring benefits that are greater than proportional to total body mass lost.

Re: GLP-1s are being linked to fewer serious infections, including TB

#30
post #4

How expensive are GLP-1s again?

How technical do you want to get? The grey-market price from China, is about $100 for 10 x (30mg/mL, 10mL) vials of Tirzepatide. Semaglutide is cheaper. At the highest dose of 15mg/wk, that's 20 weeks for $100.

For example?
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