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Launch HN: RonanRX (YC S26) – Personalized Peptides and GLP-1s

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Re: Launch HN: RonanRX (YC S26) – Personalized Peptides and GLP-1s

#61

Post by intoXbox »

lloydarmbrust wrote: post #24
rootsudo wrote: post #8

You know the answer was obvious and I didn’t think to submit this to ycombinator since the idea is basically you’re front running a compounding pharmacies. This is combining a compounding pharmacy and an MSO. At the same time, nothing is stopping you from hiring a fractional medical director and doctors alongside NP. I ran the numbers and 50k is is all you need to get a service agreement with a compounding pharmacy,…

You seem to know a lot about this, and I was nodding along with a lot of your points as I was reading. I was Stripe's first customer in 2010, so we solved the credit card processing issue :) it turns out that being in YC is good for more than just money. You are right about HIPAA, everyone thinks this is much harder than it actually is, but GCP, OpenAI, Linq, everyone has given us a BAA. We're definitely not trying t…

Don’t newly produced meds require new FDA clearance/approval, with clinical testing and all the like? I mean how else can you prove that your new drug production is effective and causes no new harms

Re: Launch HN: RonanRX (YC S26) – Personalized Peptides and GLP-1s

#62

Post by elil17 »

lloydarmbrust wrote: post #51
ipsum2 wrote: post #30

Off by one letter compared to "Roman", which is a GLP prescriber farm, but you already knew this :). Hoping for a lawsuit to boost your fame? https://en.wikipedia.org/wiki/Ro_(company)

The truth is a lot less exciting. We got into YC and registered the company name that night, and the domain name was available. The Ro connection was pointed out later. If we are forced to rebrand, we will be more thoughtful.

lmao this comment is going to be pulled up by the plaintiff's lawyers and used to show willful infringement. someone's going to be paying treble + plaintiff's legal fees

seriously though you should probably consult a lawyer about whether to change the name, especially given that you've posed this comment in public

Re: Launch HN: RonanRX (YC S26) – Personalized Peptides and GLP-1s

#63

Post by elil17 »

frantathefranta wrote: post #32
ipsum2 wrote: post #30

Off by one letter compared to "Roman", which is a GLP prescriber farm, but you already knew this :). Hoping for a lawsuit to boost your fame? https://en.wikipedia.org/wiki/Ro_(company)

I guess I don’t look at company Wikipedia pages very often but this one seems particularly “written by corporate”.

In general yes, but what about this sentence:

> Reitano's personal experience with a heart condition, and his desire to recreate his father, a doctor, out of software as a hologram, inspired him to co-found the company.

Re: Launch HN: RonanRX (YC S26) – Personalized Peptides and GLP-1s

#64

Post by tomhow »

faangguyindia wrote: post #56
lloydarmbrust wrote: post #54

Earlier quoted context omitted.

I'm just asking if you've ever used one. I don't want to assume, but if you've used one, you would understand the benefits are far greater than weight loss.

[flagged]

Please don't harangue people about exercise and diet on HN. Everyone has heard it countless times here and elsewhere. Obviously, many people find that approach doesn't (easily) work. Yes, it's well known GLP-1s can have negative effects. Many people still find them beneficial anyway, and many people take measures to address the negative effects. None of this is simple or easy, so please stop making it out like it should be a simple or easy decision for people to just do as you suggest.

In HN guidelines terms, these sections are relevant:

Be kind. Don't be snarky. Converse curiously; don't cross-examine. Edit out swipes.

Comments should get more thoughtful and substantive, not less, as a topic gets more divisive.

Eschew flamebait. Avoid generic tangents. Omit internet tropes.

Please don't post shallow dismissals, especially of other people's work. A good critical comment teaches us something.

https://news.ycombinator.com/newsguidelines.html

Re: Launch HN: RonanRX (YC S26) – Personalized Peptides and GLP-1s

#65

Post by faangguyindia »

tomhow wrote: post #64
faangguyindia wrote: post #56

Earlier quoted context omitted.

[flagged]

Please don't harangue people about exercise and diet on HN. Everyone has heard it countless times here and elsewhere. Obviously, many people find that approach doesn't (easily) work. Yes, it's well known GLP-1s can have negative effects. Many people still find them beneficial anyway, and many people take measures to address the negative effects. None of this is simple or easy, so please stop making it out like it sho…

Pushing drugs to people which can crash your appetite is much more dangerous than promoting exercise and diet to sedentary people.

Getting 20 kg overweight only requires a 100 kcal surplus over a period of 4 years.

That's not proof that diet and exercise are not working, and it doesn't prove you need GLP-1s to resist an extra 100 kcal a day. Two slices of bread have 130 kcal for comparison.

Re: Launch HN: RonanRX (YC S26) – Personalized Peptides and GLP-1s

#67

Post by dimaggiosghost »

anonymous391084 wrote: post #49
rootsudo wrote: post #47

Earlier quoted context omitted.

Me too. I get owning the supply chain and the compounding part. There is big deal about 503a and 503b compounding pharmacies as well. That's why the website copy is overdone with "for you" to qualify as and the example on the bottom shows Semaglutide and Cyanocobalamin (Vitamin b12) because that is the current FDA loophole . They can not just offer the main compounded chemical/medicine but must combine it (alongside…

I respect the regulatory arbitrage, but for example Uber and Airbnb both arguably had pretty revolutionary tech layers on top of that. Trying to figure out what the equivalent here is.

I'd wager the technical advantage is on the backend not the consumer facing. You'd be surprised how unsophisticated an unoptimized a lot of industries are.

On the manufacturing side of the world, "did this thing show up when I expected" is a remarkably difficult yet valuable question.

Re: Launch HN: RonanRX (YC S26) – Personalized Peptides and GLP-1s

#68

Post by tomhow »

faangguyindia wrote: post #65
tomhow wrote: post #64

Earlier quoted context omitted.

Please don't harangue people about exercise and diet on HN. Everyone has heard it countless times here and elsewhere. Obviously, many people find that approach doesn't (easily) work. Yes, it's well known GLP-1s can have negative effects. Many people still find them beneficial anyway, and many people take measures to address the negative effects. None of this is simple or easy, so please stop making it out like it sho…

Pushing drugs to people which can crash your appetite is much more dangerous than promoting exercise and diet to sedentary people. Getting 20 kg overweight only requires a 100 kcal surplus over a period of 4 years. That's not proof that diet and exercise are not working, and it doesn't prove you need GLP-1s to resist an extra 100 kcal a day. Two slices of bread have 130 kcal for comparison.

It’s this repetition of caloric balance dogma that’s most unhelpful and unwelcome here. If if was that simple, everyone would already have done it. Appetite and metabolism are not that simple and continuing to insist that they are serves only to alienate anyone who isn’t already committed to that worldview. Nobody disputes that there are risks that need to be understood and addressed.

Re: Launch HN: RonanRX (YC S26) – Personalized Peptides and GLP-1s

#69

Post by hypendev »

lloydarmbrust wrote: post #24
rootsudo wrote: post #8

You know the answer was obvious and I didn’t think to submit this to ycombinator since the idea is basically you’re front running a compounding pharmacies. This is combining a compounding pharmacy and an MSO. At the same time, nothing is stopping you from hiring a fractional medical director and doctors alongside NP. I ran the numbers and 50k is is all you need to get a service agreement with a compounding pharmacy,…

You seem to know a lot about this, and I was nodding along with a lot of your points as I was reading. I was Stripe's first customer in 2010, so we solved the credit card processing issue :) it turns out that being in YC is good for more than just money. You are right about HIPAA, everyone thinks this is much harder than it actually is, but GCP, OpenAI, Linq, everyone has given us a BAA. We're definitely not trying t…

> I was Stripe's first customer in 2010

Would love to hear more about this, sounds like a fun time.

Are you planning to move from peptides to generics in the future? Also, considering you are looking at full vertical integration, is blood testing going to be a part of the pipeline in the future or will you partner with service providers? (I assume the latter until you grow enough to expand into that?)

While peptides are currently the hot market, I definitely can see the feedback loop being a great growth driver. Having a "hands-off" medication management with doses changing based on periodical labs result would be amazing - I am on a generic med (T4) for an autoimmune, and the process is annoying:

- Get labs done

- Schedule an endocrinologist, wait

- Reach out to my GP, have them bump my medications

- Wait for them to answer/arrange a checkup

- Wait for it to clear with the pharmacy

- Repeat

If this could be condensed in a loop that is basically get labs done -> pick up prescription, it would both reduce waiting time and reduce pressure on the med system, plus could be a huge data source on drug interactions.

Oh, and one last thing - considering the peptide market is currently full of grey/black market companies, drop-shippers and affiliate resellers, how do you plan to market it?

Especially judging by the site design, if I saw this link elsewhere I'd think it was AI dropshipping slop - no offense - mostly due to classic Claude design and the AI generated bottle/video.

Besides that, congratulations on the launch - love the vision and the future it can bring, hope you become at least a decacorn!

Re: Launch HN: RonanRX (YC S26) – Personalized Peptides and GLP-1s

#70

Post by fridental »

My personal experience with GLP-1s was starting at 5 units, then progressing to 10, 15 and max it with 20 units. Where exactly do you see benefits of a personalized treatment: in the gaps between the existing doses, in ability of having even higher doses, or in dynamically changing the dose every month?
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