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Autism mutations drive neurodevelopmental pathology

science.org

141–150 of 199 posts

Re: Autism mutations drive neurodevelopmental pathology

#142
post #110

Earlier quoted context omitted.

> If you see a person without legs, do you tell him he is a piece of shit because he can't run? So why harass autistic people? If you have not yet realized it, here is a black pill for you: most people are deeply manipulative and bullying basically all the time. For example nearly all social rules that are commonly accepted in society are basically about which kinds of manipulations and bullying of other people are a…

> For example nearly all social rules that are commonly accepted in society are basically about which kinds of manipulations and bullying of other people are accepted by most people vs not. Can you elaborate on that?

Name a social rule

Re: Autism mutations drive neurodevelopmental pathology

#143
post #53
post #24

Earlier quoted context omitted.

The problem is assuming the social cues are important at this point in evolution. I'd say the opposite is true, frankly. I'm more worried about people's inability to follow simple instructions, like making a hamburger correctly.

Social cues are important for reproduction. An autist guy might not notice when girls are attracted to him. So the chances of reproduction are lower.

As an autistic man, I'm still not convinced women are attracted to men. At all.

Re: Autism mutations drive neurodevelopmental pathology

#144

Earlier quoted context omitted.

It's one of those choice not choices. I love my partner a lot. We bought a house together with a great yard with a significant fruit and veggie garden. Separating would be significantly destructive / damaging on both a personal and financial levels. That said, I entered this relationship without fully understanding the impact of an autistic child. I would not condemn anyone who refused to be in a relationship if the…

> I would not condemn anyone who refused to be in a relationship if the other person had an autistic child. Let me correct that for you, > I would not condemn anyone who refused to be in a relationship if the other person had a child. Being a step parent is one of the most difficult things a person can do. If you can’t or don’t want to do it that’s fine.

That's a good correction. Heck, leaving space for the child to grow up and have their mom when they need them and not helping if it is not asked for is difficult at times.

From my admittedly limited experience, the parent and child have relationship that will keep you on the outside even if the family has made a conscious choice to include you as a step parent. I have made a conscious choice to be okay with being on the outside.

My deepest relationship and commitment is with my partner. Everything else is secondary... except maybe watering the plants in the garden during a drought.

Re: Autism mutations drive neurodevelopmental pathology

#145

Earlier quoted context omitted.

I'm an aspie, and think my "version" of ASD has a large epigenetic component. I think social emotions that develop through childhood and adolescence happen through epigenetic changes that enable and disable sets of genetic material (not necessarily just genes) as the person develops. I think the physical changes that happen with puberty must involve timed epigenetic changes. I think the same thing happens with emotio…

If you don't feel lust, why did you have a girlfriend?

Just to be clear: are you suggesting that the only reason someone would want a companion is to satisfy lust?

Re: Autism mutations drive neurodevelopmental pathology

#146

Earlier quoted context omitted.

On the contrary, autistic people tend to be way too mature for their age, often visibly so. (it used to be called the "little professor syndrome") It seems to me that's what they actually found - the genes accelerate maturation. Maybe it's just the neoteny fetish of the modern society that makes it feel like a disorder.

Maybe but in that case they are then less mature in other ways due to not having the proper formative experiences. And what's wrong with neoteny?

[deleted]

Re: Autism mutations drive neurodevelopmental pathology

#147

Earlier quoted context omitted.

On the contrary, autistic people tend to be way too mature for their age, often visibly so. (it used to be called the "little professor syndrome") It seems to me that's what they actually found - the genes accelerate maturation. Maybe it's just the neoteny fetish of the modern society that makes it feel like a disorder.

Maybe but in that case they are then less mature in other ways due to not having the proper formative experiences. And what's wrong with neoteny?

Neoteny makes people immature. Self centered, childish, irresponsible, agressive. It's well known which dog breeds cause the majority of injuries - pittbulls, which are little more than overgrown puppies.

Re: Autism mutations drive neurodevelopmental pathology

#148

Earlier quoted context omitted.

If you don't feel lust, why did you have a girlfriend?

Just to be clear: are you suggesting that the only reason someone would want a companion is to satisfy lust?

What other reason would there be to have a girlfriend or boyfriend? Financial exploitation?

Re: Autism mutations drive neurodevelopmental pathology

#149
post #39

Earlier quoted context omitted.

There a point on the spectrum where someone cannot function without supervised housing and another one where you have non verbal autistic folks. But I agree broken is not the right word for those poor folks because they were never functional to begin with!

We need some word and "differently abled" is just silly. Being blind is a problem. It's not a moral judgment, you aren't less of a person, but you aren't going to be driving any time soon.

Disabled is the word. Not broken. Not differently abled. We have a perfectly functional word for this.

Re: Autism mutations drive neurodevelopmental pathology

#150
post #12

autism researcher here. I have not yet read this study. It will not be the kind of paper that many, including myself, can read quickly and understand. Autism is a multi-disciplined science, so there is a lot to understand. However, my initial sense from reading the abstract is that this paper might be a really really big deal and incredible new resource. General problem statement: Many different genetic variants are…

Out of curiosity, what leads us to treat ASD as an actual single disorder, as opposed to a billion different individual neurological profiles? I'd expect one of the things that makes this difficult, too, is that there's a missing component of the "machine" - the genetics affect the pathways, which affect (maybe?) things like signal propagation or network regulation in the brain, but the actual effect of that is on th…

We name them as one (autism), but try to treat each as what it is specifically
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