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Doctors are finally learning to manage antidepressant withdrawal

newscientist.com

31–40 of 377 posts

Re: Doctors are finally learning to manage antidepressant withdrawal

#31

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Most of us have no idea how many non-commenting readers w/o first-hand experience are just reading, and so no ability to draw any conclusions about the number of ones who comment with first-hand experience. 100 people out of a 1000, and 100 people out of a million, are very different things.

Re: Doctors are finally learning to manage antidepressant withdrawal

#32
post #20

Earlier quoted context omitted.

I can’t believe we’ve normalized anti depressants as a society. I’m about to get downvoted into oblivion for this take though. I’m not trying to discount mental health, I just think there are better solutions than drugs to fix your state of mind. Also think that some people are dealt a tougher hand than most, and that for a small subset of humans, anti depressants are the most fitting cure.

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There's hundreds of years of "depression isn't real and even if it was real the only treatment is to take a walk in the woods!!" and like a decade of "man, ssris are great, they really helped me".

Public responses have probably not finished overcorrecting.

Re: Doctors are finally learning to manage antidepressant withdrawal

#33

[flagged]

An HN post like this will gather like what, at most two dozens of anecdotes from a highly self selected user pool of maybe a million top? Is this how you base your "sheer number" on? Is this how you judge what is good or bad for your definition of social good?

I got some other news for you, buddy. https://news.ycombinator.com/item?id=49444514

Re: Doctors are finally learning to manage antidepressant withdrawal

#34
post #7

To provide one additional anecdote: I came off escitalopram with no taper after taking it for about five years (10mg). I got brain zaps for a while, got very irritated at times, but largely was fine after a few weeks. Not downplaying the withdrawal effects for some people, but they’re not as catastrophic as this article suggests for many (perhaps most). And overall I’m very glad I took it! It got me through a rough p…

It can be catastrophic if one is managing family life, kids, taking them to and from activities on top of one’s own work. Then come misc stresses like tax returns, some expensive home repair, etc. Also dealing with depression without the anti-depressant. Switching mental health medication is no fun.

I am glad your experience was tolerable but it’s a whole arc and everyone’s tolerance + circumstances are unique which makes it all the more challenging (even for doctors).

Re: Doctors are finally learning to manage antidepressant withdrawal

#36

Best way to manage the withdrawal would be to dramatically reduce them being prescribed in the first place. The linked article says they have "small to moderate effectiveness", but this is being far too generous. The correct way to measure drug effectiveness is if the treatment meets the standard of a minimal important difference. I.e. you measure depression on various rating scales, like the 17-point HAM-D, and rese…

So did you take them and have a bad time? Because they definitely work for me and I doubt a placebo could have such a large effect on the 48 hour stomach pains I used to get alongside my frequent panic attacks. I find it funny that people complain about emotional blunting when that is the entire purpose of the drug. I would prefer not to live on the razors edge ever again. I’ve had chronic anxiety and depression ever…

SSRIs have much more clinical evidence of efficacy for addressing anxiety disorders vs a placebo than depression. The effect size is ~0.7 vs 0.2 in meta studies.

Re: Doctors are finally learning to manage antidepressant withdrawal

#37
SSRIs and SNRIs just didn't work very well for me. If they had an positive effect at all, it wasn't enough to rise above the proverbial noise.

Coming off of them wasn't too bad though. I got the brain zaps, but those were easy to cope with.

More than anything the whole experience was a waste of money, and what finally fixed my problems was retirement and a greater attention to my health.

Re: Doctors are finally learning to manage antidepressant withdrawal

#39
post #20

Earlier quoted context omitted.

I can’t believe we’ve normalized anti depressants as a society. I’m about to get downvoted into oblivion for this take though. I’m not trying to discount mental health, I just think there are better solutions than drugs to fix your state of mind. Also think that some people are dealt a tougher hand than most, and that for a small subset of humans, anti depressants are the most fitting cure.

I don’t get why people are so negative about drugs. They’re just a medical treatment, with pluses and minuses. If they help and they’re not too costly then what’s the big deal? Half the population is addicted to caffeine and nobody cares. A huge number of people need medical intervention for other things and we don’t get this quasi moralistic opposition to them.

Agreed. The problem is largely that the pluses of antidepressants have been quite significantly overstated, and the minuses have been understated, meaning the cost-benefit equation is unfortunately quite different than what the general public assumes.

We don't want to get rid of them, we just need to recalibrate prescribing, and also to properly assess cessation at intervals more frequently than we have been.

Re: Doctors are finally learning to manage antidepressant withdrawal

#40

Earlier quoted context omitted.

On an academic level, we have reined in much of the excess enthusiasm in antidepressants that was courtesy of 90s-era pharmaceutical reps and ad men, but I don't think this revision ever occurred in the cultural consciousness at large.

See also: The Serotonin Theory of Depression: a Systematic Umbrella Review of the Evidence (2022). It's worth reading the introduction and results in full, but here are two important quotes (footnote markers removed): > Our comprehensive review of the major strands of research on serotonin shows there is no convincing evidence that depression is associated with, or caused by, lower serotonin concentrations or activit…

The "chemical imbalance" theory is objectively wrong, but still useful in that it conveys the fact that mental disorders have physical causes. It's a purposeful simplification.
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