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Pathogen from gut of obese human causes obesity in germfree mice

nature.com

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Re: Pathogen from gut of obese human causes obesity in germfree mice

#71

Post by wildranter »

splatcollision wrote: post #18

Gut bacteria are an extremely powerful system within our bodies and are mostly still mysterious to us. Imbalances of one type or another lead to large amounts of bacterial toxins being introduced to the intestine and the bloodstream, with wide-ranging mental and physical effects. I'm not surprised that contribution to obesity is among them. It works kind of like this: You eat too much refined/processed food, that is…

I went straight to the food list. They lost me at coffee should be VERY weak. They can't take that away from me! :)

Re: Pathogen from gut of obese human causes obesity in germfree mice

#72

Post by freshhawk »

indiecore wrote: post #24
panzagl wrote: post #8

Earlier quoted context omitted.

You're right, we should all lament the possible passing of another way of judging people inferior to us.

I don't care if someone is fat. What I care about is the loons saying that it's healthy and fine to be morbidly obese and they use stuff like this to back it up. "Gut bacteria are the cause, I can do nothing" "It's genetics" No, it's calories in vs calories out. Maybe these bacteria make you want to eat more, maybe they somehow pull more energy out of food than normal gut flora somehow, in the end it doesn't really m…

God this calories in / calories out shit has got to die.

Stop leaving out the fucking calorie absorption efficiency factor if you don't want to sound like just as much of an idiot as the people you are complaining about.

Gasoline has a shitload of calories in it. You will definitely not get fat drinking it.

There is literally no one in the field who thinks this is true or ever did. There is certainly an argument about how widely the absorption efficiency varies from person to person, but that's not the same thing as the assertion that it is simply 100% all the time for everyone.

Re: Pathogen from gut of obese human causes obesity in germfree mice

#73

Post by justincormack »

patrickgzill wrote: post #35

It is interesting to consider that periodic fasts and/or abstaining from certain foods for a time (such as Lent during the Orthodox calendar), seen in many religions, might have a health benefit by suppressing certain gut bacteria, or at least managing gut flora.

American obesity is a recent thing that does not eg seem to be related to stopping fasts.

Re: Pathogen from gut of obese human causes obesity in germfree mice

#75

Post by Alex3917 »

gamache wrote: post #68
Alex3917 wrote: post #27

Earlier quoted context omitted.

"[the pathogen] can induce obesity and insulin resistance via an inflammation-mediated pathway" This is why weed reduces one's risk of diabetes and also often helps obese people lose weight.[1] For what it's worth, you can now actually (supposedly) buy CBD (supposedly) legally online: http://dixiex.com/ CBD is one of the more common non-psychoactive cannabinoids in marijuana, and it is responsible for many of the ant…

CBD is most definitely psychoactive. It also accounts for about 25-50% of marijuana's active components, so we are living in a world full of long-term data. Cannabidiol is most definitely illegal in the US, too. That DixieX site you link to is just hemp oil products -- no psychoactives.

CBD is considered non-psychoactive by fiat. This is because it has a low affinity for receptor sites in the brain and it doesn't cause significant impairment. You may or may not be able to feel it though. And it's definitely not 25-50% of most commercial strains (unless specifically bred for it), that may be true of certain landrace varietals though.

Also the amount of cannabinoids DixieX is citing is actually the minimum CBD content. They show their lab results on their Facebook page. The reason the don't cite the CBD content is because CBD is illegal, but hemp products are legal if the THC content is below a certain level. They're trying to play it off as a legal grey area and are taking a calculated risk.

Re: Pathogen from gut of obese human causes obesity in germfree mice

#76

Post by not_that_noob »

indiecore wrote: post #20
not_that_noob wrote: post #7

Earlier quoted context omitted.

One can argue it was the calorie restriction and not the bacteria. However, the interesting part was that the pathogen then caused the mice to gain weight.

Probably because it made the subjects want to eat more. There's no magic bullet for gaining or losing weight, you either eat more or less that your body needs.

Interesting. Being satiated after a meal is really a marker for obesity - if you eat less to get to your satiation point vs. someone else who has to eat more to get there, you're less likely to put on the pounds. I wonder if this pathogen messes with that sense of being satiated.

Re: Pathogen from gut of obese human causes obesity in germfree mice

#77

Post by msarvar »

Able7 wrote: post #62
ChuckMcM wrote: post #9

Ok, this is an interesting observation: "After 9 weeks on the WTP diet, this Enterobacter population in the volunteer's gut reduced to 1.8%, and became undetectable by the end of the 23-week trial" So the thesis is that this bacteria lives in obese people's gut, and it makes them more obese. But once they diet to a point where they are not obese, the bacteria dies off? I wonder if they are going to try a diet + anti-…

No antibiotics were involved but the WTP diet consisted of 1344Cal daily diet of canned porridge (. . ."4 cans of gruel per day" . . .) - Quoted from 'Supplimental Material' to the original study publication http://www.nature.com/ismej/journal/vaop/ncurrent/extref/ism... . But, there is absolutely no specific information as to the actual ingredients of the "porridge/gruel" so there seems to be no way to actually repe…

So they basically put him on a strict low calorie diet, and he lost weight? No way!

Re: Pathogen from gut of obese human causes obesity in germfree mice

#78

Post by [deleted] »

Able7 wrote: post #62
ChuckMcM wrote: post #9

Ok, this is an interesting observation: "After 9 weeks on the WTP diet, this Enterobacter population in the volunteer's gut reduced to 1.8%, and became undetectable by the end of the 23-week trial" So the thesis is that this bacteria lives in obese people's gut, and it makes them more obese. But once they diet to a point where they are not obese, the bacteria dies off? I wonder if they are going to try a diet + anti-…

No antibiotics were involved but the WTP diet consisted of 1344Cal daily diet of canned porridge (. . ."4 cans of gruel per day" . . .) - Quoted from 'Supplimental Material' to the original study publication http://www.nature.com/ismej/journal/vaop/ncurrent/extref/ism... . But, there is absolutely no specific information as to the actual ingredients of the "porridge/gruel" so there seems to be no way to actually repe…

[deleted]

Re: Pathogen from gut of obese human causes obesity in germfree mice

#79

Post by indiecore »

LaGrange wrote: post #59
indiecore wrote: post #43

Earlier quoted context omitted.

Dieting isn't a magic bullet you fool, it's long, hard and worth it .

Just being hard, or even applicable in some cases, doesn't make it less of a magic bullet when someone suggests it's applicable to a broad problem.

> Controlling calorie intake is hardly a magic bullet. That's like saying exercise is the magic bullet for gaining muscle or studying is a magic bullet for passing exams.

Re: Pathogen from gut of obese human causes obesity in germfree mice

#80

Post by Roshini »

splatcollision wrote: post #18

Gut bacteria are an extremely powerful system within our bodies and are mostly still mysterious to us. Imbalances of one type or another lead to large amounts of bacterial toxins being introduced to the intestine and the bloodstream, with wide-ranging mental and physical effects. I'm not surprised that contribution to obesity is among them. It works kind of like this: You eat too much refined/processed food, that is…

No. It is pretty much impossible to overload your body's ability to absorb carbohydrates without a) exploding your stomach or b) you have some other health problem. By the time the food you eat gets to the bacteria, there are no sugar, fat or protein left. We absorb it all. We store extra of the first two and excrete the third (in a modified form) through urine.

Refined/processed food should be eaten in minimal quantities because it spikes blood sugar and causes insulin fatigue, which in the long run causes Type II diabetes.

And I'm in medical school, so yes, I do know what I'm talking about.

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