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FDA authorizes first wearable device that monitors ketone and blood sugar levels

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Re: FDA authorizes first wearable device that monitors ketone and blood sugar levels

#121

Post by ggm »

umvi wrote: post #88

Ketones are only going to be present if you are exceptionally bad (very high carb diet) or exceptionally good (very low carb diet) at managing your blood sugar. It's not going to be terribly useful for your average diabetic who has fairly good control over their blood sugars.

A measure which acts as a high and a low pass filter on a band of less risk which can be monitored by other means, or subject to improvements on measurements and narrow the central zone?

Sounds bloody useful to me.

Re: FDA authorizes first wearable device that monitors ketone and blood sugar levels

#122

Post by [deleted] »

happyopossum wrote: post #9
grahar64 wrote: post #7

Looked after my son who has T1D for now 5 years, checked keytones maybe 20 times. Compared to blood glucose which we check look at every 5 minutes. Maybe this is more for Type 2 or other diabetes, or for people prone to DKA. Or it is for people with a working pancreas who think looking at their blood sugars (and now keytones) tells them something like soothsayers reading tea leaves

Considering that DKA accounts for 160k hospital admissions a year, your lived experience translates poorly to such a flippant dismissal. [0] https://www.cdc.gov/diabetes/about/diabetic-ketoacidosis.htm...

[deleted]

Re: FDA authorizes first wearable device that monitors ketone and blood sugar levels

#123

Post by eoamk »

ijustlovemath wrote: post #82
eoamk wrote: post #72

Earlier quoted context omitted.

There doesn't seem to be a continuous lactate sensor on the market. Lactic acid production and/or clearance are definitely useful data w.r.t. exercise (many training regimens talk about lactate thresholds) and also useful in in-patient settings. No disagreement about AGC in the hospital -- there is a lot of lab/titration work in current clinical workflows for monitoring patient glucose levels.

Lactate's available in the internal engineering data of these sensors, just not something that anyone has wanted to spend the time or money to qualify with the FDA. It essentially comes "for free" due to the chemical reaction the sensor uses.

I think you are misinformed: the electrochemical reaction used by continuous glucose sensors relies on a glucose-specific enzyme and it doesn't have anything to do with lactate. Lactic acid strips use a completely separate enzyme/reaction.

Hat tip to you and sibling comment about continouous lactate sensors (seem like they are microneedle/patch based?). Quick review shows minimal clinical evidence, but maybe that's sufficient for the consumer wearable market.

Re: FDA authorizes first wearable device that monitors ketone and blood sugar levels

#124

Post by jimbobimbo »

robbiep wrote: post #91
jimbobimbo wrote: post #86

Earlier quoted context omitted.

That's what I thought too, until I got my last bloodwork results and started wearing one of the OTC continuous glucose monitors. That device helped a lot to switch diet habits.

Can you be specific about what your bloodwork results showed and what special insights your CGM gave you and what behavioural changes it led to? My anecdotal experience from doctor colleagues giving CGM to patients is that it does 3/5ths of fuck all to everyone except those with actual insulin dependent diabetes (T1 or T2) because when you get down to it the insights aren’t that great and most people actually aren’t…

My story is: I had a really bad crash after eating a chocolate, which never happened before. That prompted the bloodwork, which shown that A1c was not where it's supposed to be.

I bought CGM myself, without any doctor's input. Didn't know they exist before reading some selfhelp book which my wife found.

Echoing another poster, it's eye opening how some of the foods you'd never think of, are spiking glucose levels.

Overall, after both me and my wife adjusted diet, much better energy through the day, no crashes.

Re: FDA authorizes first wearable device that monitors ketone and blood sugar levels

#125

Post by dweekly »

madrox wrote: post #113

A friend died of diabetic ketoacidosis. He loved technology and seeing people succeed. Thinking of him with this news. Miss you Dan. Grateful we're moving forward on so many fronts in the world.

He was my roommate in 2001 in San Jose.

We came up with the idea of having a place where nerds could come together to hang out and learn from each other and we decided to call the concept "Hacker Dojo". I had a sign laser engraved in 2002 at a state fair to memorialize the idea but we didn't actually get to open a Hacker Dojo until 2009.

There's a conference room in it called Kaminsky.

Dan was not a very good roommate but man, his brain worked in weird and wonderful ways, and it was inspiring how he could just rabbit-hole on stuff other people didn't find interesting until he MADE it interesting and found things nobody else had.

I miss him too. What a gift he was to the world.

Re: FDA authorizes first wearable device that monitors ketone and blood sugar levels

#126

Post by jamiek88 »

maddie0 wrote: post #119
agumonkey wrote: post #94

Earlier quoted context omitted.

sample of 1, but yeah changing my diet (very low sugar, more veggies) did alter my health visibly and rapidly. to the point that if I eat something too sweet too fast i have a very mild headache soon after, my system readjusted to not seek levels i grew up with

fwiw... if sugar gives you a headache, this may be related to a gastrointestinal issue (e.g. gluten sensitivity, dietary histamine sensitivity, small intestinal bacterial overgrowth possibly causing its own sensitivities...) The specifics of the cause in your case are between you and your doctor, but i'd like more people to know, especially since these sorts of problems disproportionately affect people with autism an…

Woah. I have ADHD and most of these symptoms.

Re: FDA authorizes first wearable device that monitors ketone and blood sugar levels

#127

Post by lokar »

ijustlovemath wrote: post #99
jamesgill wrote: post #96

Earlier quoted context omitted.

Automated glucose control is already available via wearable insulin pumps combined with CGMs in a 'closed loop' system.

None have been approved for hospital use as of yet, which is the next frontier.

Why is hospital use so important?

Re: FDA authorizes first wearable device that monitors ketone and blood sugar levels

#128

Post by ijustlovemath »

eoamk wrote: post #123
ijustlovemath wrote: post #82

Earlier quoted context omitted.

Lactate's available in the internal engineering data of these sensors, just not something that anyone has wanted to spend the time or money to qualify with the FDA. It essentially comes "for free" due to the chemical reaction the sensor uses.

I think you are misinformed: the electrochemical reaction used by continuous glucose sensors relies on a glucose-specific enzyme and it doesn't have anything to do with lactate. Lactic acid strips use a completely separate enzyme/reaction. Hat tip to you and sibling comment about continouous lactate sensors (seem like they are microneedle/patch based?). Quick review shows minimal clinical evidence, but maybe that's s…

I've had the fortune to work with several CGM OEMs behind the scenes as part of our work developing an artificial pancreas, they all have a secret lactate signal!

Re: FDA authorizes first wearable device that monitors ketone and blood sugar levels

#129

Post by ijustlovemath »

lokar wrote: post #127
ijustlovemath wrote: post #99

Earlier quoted context omitted.

None have been approved for hospital use as of yet, which is the next frontier.

Why is hospital use so important?

If the large studies are to be believed, you could save hundreds of thousands of lives and many billions in excess expenditure, because stable blood glucose shortens length of stay. People with diabetes alone account for 60% of hospital expenditure, so improving their care improves the system in a big way.

Re: FDA authorizes first wearable device that monitors ketone and blood sugar levels

#130

Post by [deleted] »

malfist wrote: post #75
andy_ppp wrote: post #62

Earlier quoted context omitted.

I’m willing to bet we can see longevity improvements from better blood sugar control. Not 100% certain but extremely likely, this would include potential heart attack and dementia reduction…

This has been tested actually. A clinical trial looking at tight blood sugar regulation was aborted after it resulted in multiple cardiac events.

[deleted]
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