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Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

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Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#101

Post by lakhim »

Noaidi wrote: post #50

I for one would like to see the data rather than a press release. Is this even serious? A press release with no link to outside twitter? I feel like everything companies, and presidents, say now is directly geared to triggering AI trades. The only thing they are looking at with this drug is people living one more month over existing drugs. THIS IS NOTHING. "The median PFS (progression-free survival) for KEYTRUDA was…

you're also looking at a different, older study. Keytruda is a little strange in that it has a very long tail in survivorship, works best in certain cases, and median PFS isn't a really great metric.

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#102

Post by dosisking »

Someone1234 wrote: post #13
reenorap wrote: post #12

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> For all the hate I have for the COVID vaccine Can you clarify that? It saved 100K+ lives even by incredibly conservative estimates, and allowed life to returned to normal at least a year earlier than otherwise.

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Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#103

Post by HedonicEscal8r »

danjl wrote: post #69

Will this targeted approach be beneficial to other cancer types? Is there any data or theory about this class of drugs as a more general therapy?

Yes, mRNA vaccines are promising for many but not all cancer types, and there are many ongoing clinical trials. There's also a lot we yet don't know about how to design them.

Here's a great blog post on this, "How to build a cancer vaccine, and whether they will work this time": https://www.owlposting.com/p/how-to-build-a-cancer-vaccine-a...

Here's the blog post I wrote on personalized mRNA vaccines: https://hedonicescalator.substack.com/p/did-paul-conyngham-r...

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#104

Post by dosisking »

estearum wrote: post #85
ifyoubuildit wrote: post #67

Earlier quoted context omitted.

Vaccines that have a large impact on transmission and infection are there not just for you but for your community. The covid shots were good against hospitalization and death in older folks, but they were not great at preventing infection or transmission (despite what you may have gleaned from the speakers blaring ads in every public setting for all that time). You can fall back to the "flooding the hospitals" argume…

You're misinterpreting data here. You are conflating the fact that the clinical trials didn't measure infection/transmission (which is very hard to do in a clinical trial) with the distinct claim that they didn't reduce transmission in reality. The vaccines were extremely effective at reducing transmission during the first waves of COVID, where such an intervention was most valuable. And due to viral growth dynamics,…

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Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#105

Post by addisonl »

paulpauper wrote: post #93
GenerWork wrote: post #4

This is great news! I think people forget how anti-skin cancer protocols even as simple as applying suntan lotion weren't as popular as recent as 50-60 years ago. Lots of "sun children" of the 50s and 60s are now feeling the repercussions of only applying baby oil and are getting hit with lots of melanoma.

melanoma , unlike the others, has a much weaker link to sun exposure. its why melanoma often appear in areas with no sun exposure

Misleading comment.

From https://onlinelibrary.wiley.com/doi/10.1002/ijc.35463

> Cutaneous melanoma (CM) accounted for around 331,700 cancer cases globally in 2022

> An estimated 267,353 (95% uncertainty intervals [UI]: 242,818, 278,638) CM cases were UVR attributable globally in 2022

UVR = Ultraviolet radiation

Cutaneous melanoma (CM) is the vast majority of melanoma cases in the US at least:

> The percentages of melanomas that were cutaneous, ocular, mucosal, and unknown primaries were 91.2%, 5.2%, 1.3%, and 2.2%, from https://pubmed.ncbi.nlm.nih.gov/9781962/

tl;dr ~80% of Cutaneous melanoma cases are attributable to UV exposure.

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#106

Post by HedonicEscal8r »

paulpauper wrote: post #95
danjl wrote: post #69

Will this targeted approach be beneficial to other cancer types? Is there any data or theory about this class of drugs as a more general therapy?

Individualized immune cancer therapy has been touted as the next big thing for half a century. It's nothing new, and with few exceptions, such as skin cancer, has failed to yield much. scientists, for decades, have tired to harness the immune system to attackcancer and it almost never works.

Personalized mRNA vaccines are in fact, extremely new, and only made possible by recent advances across multiple fields. This comment reveals a total lack of basic understanding on this topic.

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#107

Post by jambalaya8 »

dosisking wrote: post #83
estearum wrote: post #66

Earlier quoted context omitted.

+1 the public health apparatuses' actual statements were impressively correct even if you don't account for the underlying uncertainty at the time. Where public health officials "failed" was not having a megaphone loud enough to drown out the game of telephone that most people (as these comment threads consistently show) were actually hearing information through. Simplest example: People will say that public health o…

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Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#108

Post by HedonicEscal8r »

calebkaiser wrote: post #60
Noaidi wrote: post #50

I for one would like to see the data rather than a press release. Is this even serious? A press release with no link to outside twitter? I feel like everything companies, and presidents, say now is directly geared to triggering AI trades. The only thing they are looking at with this drug is people living one more month over existing drugs. THIS IS NOTHING. "The median PFS (progression-free survival) for KEYTRUDA was…

1. That's not what progression-free survival means. 2. I don't think AI was mentioned once in this press release. 3. This drug was approved for trial in 2014, so if it had something to do with deep learning, that would actually be a massive announcement. 4. The paragraph immediately following the one you clipped talks about Overall Response Rate (ORR) and throughout the release they discuss Overall Survival (OS). 5.…

Interjecting with a fact. Moderna described the neoantigen immunogenicity prediction algorithm they used to design the vaccines as “a deterministic machine learning (ML) algorithm,” so it may be a small neural network or more traditional algorithm, probably not deep learning.

Re: Moderna reports first positive Phase 3 for mRNA neoantigen therapy in melanoma

#109

Post by jambalaya8 »

estearum wrote: post #66
Arkhaine_kupo wrote: post #41

Earlier quoted context omitted.

> People were assured that COVID vaccine mRNA would disappear within days and the spike protein would short-lived which is still the case, even in the Yale study. > That is a massive gap between what the public was told and what later evidence found. there is an even larger gap between basic epidemiology and what the public understands. Hard science is difficult to communicate on a good day, on a global pandemic with…

+1 the public health apparatuses' actual statements were impressively correct even if you don't account for the underlying uncertainty at the time. Where public health officials "failed" was not having a megaphone loud enough to drown out the game of telephone that most people (as these comment threads consistently show) were actually hearing information through. Simplest example: People will say that public health o…

Masks might work but you have to take them off at some point to change them. Or blow your nose, from all of those dead skin cells.
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