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Semaglutide linked to lower predicted dementia risk
341–350 of 430 posts
Re: Semaglutide linked to lower predicted dementia risk
#342Very american thread and comments. At most I was 24 BMI and I felt like a fat bastard during COVID. Work from home in sweatpants and I got up to 24 BMI. 77-78kg, 182cm. I just did not weigh myself so I actually did not notice I had gained! But I did and decided to do something about it. But I lost the weight pretty quickly. I grew up at 60-65kg and that is where I feel at home in my body. I feel like myself basically…
I used to be similarly judgemental and flippant when my BMI was 20~21 in my 20s and 30s. My health took a few wrong turns and I now have a BMI of 30. My diet is just as good, if not better, than back when I was slim. But now my sleep is worse, I tire much more easily, recover much worse from exercise, and, crucially, I am much hungrier. I no longer preach how simple it is to maintain a healthy weight. I should have k…
I should add I am 35 and male, so certainly no spring chicken!
I haven't slept a full night in years due to having to get up and pee or waking up for some reason. Maybe sleep apnea but I haven't bothered to get it checked.
My diet is like crap, I eat junk food, sandwiches and chips and zero calorie soda.
Still 19-21BMI now as I weigh myself daily to keep in check. And having been 24BMI back down to 19-20BMI, I know it can be done and how to do it.
Maybe if I am 55 it will get harder sure.
But I just dont get as much dopamine from eating as others I guess. As the thinspo girls on TikTok, Youtube say "Eating is not the main event."
Thank you for commenting as I notice a lot of people just downvote or think I am trolling, but I am honest here but I dont express myself very well.
I am cought between two worlds, I am not smart enough to be here really, but not dumb enough to start commenting on TikTok. I belong on 2009 Reddit but that Reddit is long gone... thanks for letting me ramble. Hope the mods dont come and get me again.. u.u
Re: Semaglutide linked to lower predicted dementia risk
#343Very american thread and comments. At most I was 24 BMI and I felt like a fat bastard during COVID. Work from home in sweatpants and I got up to 24 BMI. 77-78kg, 182cm. I just did not weigh myself so I actually did not notice I had gained! But I did and decided to do something about it. But I lost the weight pretty quickly. I grew up at 60-65kg and that is where I feel at home in my body. I feel like myself basically…
Yes, the world is very aware of how to lose weight.
Turns out knowledge doesn't work very well, or rather loses efficacy in certain environments. Individuals can vary in their ability to regulate the hunger response signal they feel, which is stronger with higher weight (as your body now needs more calories to maintain its larger size).
GLP-1s don't appear to have such an efficacy loss and do work well. Sometimes with minimal to no side effects.
Your arrogance shows you don't understand population level weight gain, or the biology of weight loss difficulty. Obviously calorie deficits lead to weight loss. But that isn't the hard part. It never was.
Re: Semaglutide linked to lower predicted dementia risk
#344Earlier quoted context omitted.
I'm using reta myself, but honestly it's because sema/tirz isn't allowed for me either. If you have medical tirz available, you should have some serious reasons to jump into the unregulated shark tank.
How has it been treating you? Do you keep muscle mass without having to hit 1g/lb of protein intake daily?
Haven't measured it exactly, but haven't noticed a reduction in my lifts either.
I do have a home gym, throttled my marathon training and try my best with Skyr and protein shakes though.
Re: Semaglutide linked to lower predicted dementia risk
#345Diabates can harm the brain either indirectly, through vascular damage, or directly through nerve cell degeneration. The latter is a less studied mechanism and can explain the benefit from GLPs. But I agree, it's not different than a low calorie diet. In the modern times of abundance and sedentary lifestyle, fasting makes wonders. So, if you have even one vascular risk factor, just cut your calories in half, just stop eating. Your body will thank you.
Re: Semaglutide linked to lower predicted dementia risk
#346Diabates can harm the brain either indirectly, through vascular damage, or directly through nerve cell degeneration. The latter is a less studied mechanism and can explain the benefit from GLPs. But I agree, it's not different than a low calorie diet. In the modern times of abundance and sedentary lifestyle, fasting makes wonders. So, if you have even one vascular risk factor, just cut your calories in half, just sto…
GLP-1 provides the only plausible way to do so.
Re: Semaglutide linked to lower predicted dementia risk
#347Earlier quoted context omitted.
Similar experience here on minimal dose of GLP-1. There is definitely something going on here other than "you are just losing weight and that's really why you are healthier". With my labs at my current weight you can not tell that I am a type 2 diabetic. Previously, when I was at this very same weight in the past - all my labs indicated I was prediabetic.
Could be just because you stopped eating bad food. Things improve dramatically once you limit your intake of industrialized food.
People's habits usually don't change. They still eat the same plastic crap, just less of it.
Re: Semaglutide linked to lower predicted dementia risk
#348So has anyone managed to separate the effects of semaglutide from the effects of weight loss? If this is caused by the weight loss, it is a little disappointing that public health didn't act quicker - lots of people have been overweight for a century now, so literally 10's of millions of people could have been saved from dementia had action been taken 100 years ago.
All my immediate family members are obese. I'm not (BMI 24.5, borderline overweight at the high end of normal, highest lifetime BMI was 29.5), but that's through strenuous, exhausting effort over decades. I also exercise regularly, though I've learned over time how disconnected exercise is from weight management. At my weight, I'm not a candidate for going on a GLP-1. I'm sure I could find an unethical doctor to pres…
You should start Metformin now and thank me later.
Re: Semaglutide linked to lower predicted dementia risk
#349Earlier quoted context omitted.
There are several studies now showing that symptoms reported by overweight patients are taken less seriously by medical professionals, it’s not just a matter of people “being nice”. It’s actually providing a lower standard of care.
There are several studies now showing that recommendations like "losing weight" are taken less seriously by overweight patients.
I should clarify that my doctor explicitly lied to me (found out by requesting my medical file after moving) to shock me on purpose because of his own fifth grade understanding of psychology.
Re: Semaglutide linked to lower predicted dementia risk
#350Earlier quoted context omitted.
What downsides have you experienced?
I personally found that it seemed to globally lower any kind of reward-seeking behavior - initially it was alcohol (didn't make a dramatic difference for food), but pretty quickly I quit the running habit I'd had for years. My resting heart rate shot up, my heart rate variability plumetted, and a couple months in I stopped feeling motivated to get out of bed in the morning. I lost about a half a pound a week, which w…
Interestingly, hedonism is killed in me by metformin, in food and unrelated domain.