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Semaglutide linked to lower predicted dementia risk

alz-journals.onlinelibrary.wiley.com

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Re: Semaglutide linked to lower predicted dementia risk

#241

Post by christina97 »

londons_explore wrote: post #23

So has anyone managed to separate the effects of semaglutide from the effects of weight loss? If this is caused by the weight loss, it is a little disappointing that public health didn't act quicker - lots of people have been overweight for a century now, so literally 10's of millions of people could have been saved from dementia had action been taken 100 years ago.

GLP-1s seem like a night and day difference in intervention adherence though. For various obvious and non-obvious reasons, it’s very hard to produce an intervention that people will adhere to to make the test group lose weight.

Re: Semaglutide linked to lower predicted dementia risk

#242

Post by dawnerd »

SubmarineClub wrote: post #170
eapressoandcats wrote: post #119

Earlier quoted context omitted.

They also clearly have some impacts on metabolism. It’s well known that a challenge with dieting isn’t just eating less, it’s metabolic changes that make weight loss harder. GLP-1’s avoid that.

> metabolic changes that make weight loss harder Which are vastly overblown. I diet every year as part of bodybuilding, at a range of intensities and durations, and have never had issues with sudden metabolic changes that make it harder to lose weight.

See that’s the problem. What works for you doesn’t work for others like me that have tried dieting. It’s the food noise that’s the problem and it’s a mental issue. Glp-1 has helped me a lot. The metabolic changes are kind of insane. Even doing keto which did help lose weight didn’t have this kind of effect on me.

Re: Semaglutide linked to lower predicted dementia risk

#243

Post by 01100011 »

hattmall wrote: post #45
01100011 wrote: post #38

I'm a big semaglutide proponent after being on it for a year. I know research says it helps with inflammation, arthritis (separately from weight reduction), and all sorts of magical things. I lost 40 pounds in a year(230 to 190) at age 50. Great! I also went from being active and fat(weightlifting with some cardio) to basically having no energy. In the last year I've had arthritis appear in several joints. I'm awake…

You are a proponent, but your outcomes seem worse?

My point is that it's not all roses. Overall I'm glad I took it and will continue to do so. It's not without downsides, despite the endless stream of favorable studies on it.

Re: Semaglutide linked to lower predicted dementia risk

#244

Post by 01100011 »

anon291 wrote: post #169
kccqzy wrote: post #92

Earlier quoted context omitted.

I’m also active and fat. And to me being active is more important than losing weight; I’d rather continue to do those long 2000kcal bike rides on weekends than having a healthier BMI. I’ve heard stories of my own friends bonking during a ride and I decided that I wanted to err on the side of overeating. So semaglutide doesn’t interest me. You aren’t the only one I’ve heard who started to have no energy after being on…

Being active is great but fat is still dangerous. Let's not lie to ourselves. > decided that I wanted to err on the side of overeating The reason you bonk is because you've run out of sugar in your muscles not fat

I figured that the way I adapted out of bonking was that my liver stored more glycogen. It's just a wild guess though.

Re: Semaglutide linked to lower predicted dementia risk

#245

Post by phil21 »

card_zero wrote: post #212
llm_nerd wrote: post #155

Earlier quoted context omitted.

>The world didn't suddenly decide to get less active all of a sudden In many ways, yes it did . There is a shocking decline in active calories in every developed country, and it has been exported to the developing world as well. People are astonishingly lazy, on the average. Like, Christ, it's so bad that the recommendation to take a brief, slow walk after meals is revolutionary now. Because the average person just w…

But there's the exercise paradox, which is that it doesn't work. https://en.wikipedia.org/wiki/Exercise_paradox Possibly it works in the extremes, but if so, it's modern and unnatural.

Wear a blood glucose monitor for a month or two. Don't make any changes whatsoever to diet or activity levels for the first 2 weeks.

Then change it up so you are taking a mile or two walk after every meal. Don't change your diet.

Note the difference in blood sugar levels. It won't happen for everyone but the difference just an extremely moderate level of activity makes - especially directly after meals - was actually one of my larger surprises doing exactly the above.

If I am diligent about my 10k steps/day, I find it difficult to put on weight unless I'm eating like total crap. Combine an effort to try to never eat simple carbs with the above walking regimine and most folks are going to drop weight faster than they would ever expect. Quadruple (or more!) true if you also add a GLP-1 to the mix.

Re: Semaglutide linked to lower predicted dementia risk

#246

Post by 01100011 »

borski wrote: post #138
01100011 wrote: post #128

Earlier quoted context omitted.

2.4mg for over 6 months. I'm considering dropping back a level(1.7mg?).

You’re on too high a dose. The highest dose made me a vegetable, with no energy, and so on. That is not the way. Lower the dose (with your doctor, of course). For me, the “middle” dose was the sweet spot of positive effects with minimal side effects. You are likely a “hyper-responder” to GLP-1s. Also, tirzepatide had far fewer side effects for me, fwiw. YMMV, of course.

Yeah I probably should back off a level. I was hoping that moving to a 10-day dose schedule might give me some benefits(and save some money). I recently started doing that, although the decision to do so was mostly driven by having a stomach virus and wanting to more fully recover from the gastric effects before my next dose of semaglutide. After my first 10-day gap between doses I ended up with a strong encounter with the hypoglycemic feeling after going on a walk with my daughter. Sticking to the 1 week schedule but dropping the dosage is probably the right thing to do.

Re: Semaglutide linked to lower predicted dementia risk

#247

Post by ed_elliott_asc »

ACCount37 wrote: post #202
wolfy1993 wrote: post #94

Earlier quoted context omitted.

I'm not sure how the medical establishment ignores this, from my understanding (and please correct me if I'm wrong as I'm not fact checking myself in this moment) - the association between the two is largely linked to vascular dementia (obesity, hypertension, yadda yadda). I think it's hard to argue "The medical establishment" ignores diet as an important factor. I think the reality a lot of the time is doctors presc…

It's easy to say "just diet ez" and it's hard to "just diet". If you can administer a treatment as a simple one and done thing, that's alright. If it's a pill you got to take every day, that's pretty bad. More than once a day? Horrible. Why? Because a lot of patients just don't have it in them to take a pill 3 times a day consistently. If it's purely an "exercise willpower" thing or a "change your lifestyle" thing? Y…

You underestimate what people Will do to lose weight without putting in any effort or changing their lifestyle

Re: Semaglutide linked to lower predicted dementia risk

#248

Post by inopinatus »

bariswheel wrote: post #48

tdlr: This is a Novo Nordisk-funded study focusing on predictive biomarkers rather than real-world dementia cases. Novo Nordisk's actual dedicated clinical trials for Alzheimer's completely failed to show that semaglutide stops cognitive decline. "A predictive biomarker is like a "check engine" light on your dashboard. It warns you that there is a risk of a future problem. In this study, the researchers only checked…

Factoring out the ad corpus yelping, the interesting counterpoint is that suppressing the risk signal isn't a good thing if it doesn't suppress the risk.

Re: Semaglutide linked to lower predicted dementia risk

#249

Post by applicative »

bariswheel wrote: post #48

tdlr: This is a Novo Nordisk-funded study focusing on predictive biomarkers rather than real-world dementia cases. Novo Nordisk's actual dedicated clinical trials for Alzheimer's completely failed to show that semaglutide stops cognitive decline. "A predictive biomarker is like a "check engine" light on your dashboard. It warns you that there is a risk of a future problem. In this study, the researchers only checked…

This is one of the most distinguished peer reviewed journals on Alzheimer’s and dementia. Adults know not to make too much of a study of this scale and ambiguity. But considered as such, the paper is above suspicion.

Re: Semaglutide linked to lower predicted dementia risk

#250

Post by prescriptivist »

goda90 wrote: post #17

Isn't lower calorie consumption in general correlated to longevity? (Assuming no major malnutrition)

Sure, but there is nothing in the world of the last 30-40 years that can compare to GLP-1s in terms of helping people consume fewer calories. This is a very coarse statement, but I'm confident in making it: there is nothing healthier than being skinny, and GLP-1s make people skinny in a way that is unique in modernity. Our modern food systems are optimized to encourage people to consume as many calories as they can, and GLP-1s are bulwarks against this system, if you will.
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