Semaglutide linked to lower predicted dementia risk • Hacker News Board

Re: Semaglutide linked to lower predicted dementia risk

#191

Post by dr_dshiv » Sat, Aug 15, 2026, 9:11 PM UTC

bariswheel wrote: post #48

tdlr: This is a Novo Nordisk-funded study focusing on predictive biomarkers rather than real-world dementia cases. Novo Nordisk's actual dedicated clinical trials for Alzheimer's completely failed to show that semaglutide stops cognitive decline. "A predictive biomarker is like a "check engine" light on your dashboard. It warns you that there is a risk of a future problem. In this study, the researchers only checked…

Regarding “actual tests”: My team and I built a battery of longitudinal cognitive assessments useful for testing memory and brain function. (http://getNeuroUX.com)

Re: Semaglutide linked to lower predicted dementia risk

#192

Post by aucisson_masque » Sat, Aug 15, 2026, 9:17 PM UTC

alyandon wrote: post #69

jaggederest wrote: post #64

Earlier quoted context omitted.

I have some individual anecdotal evidence. I spent a long time, basically a year, relatively heavy but on a very small dose of GLP drugs due to tolerability issues, and my labs improved dramatically , to a degree we redid them out of disbelief, even without weight loss. I believe one of the suspected underlying causes is reduction in fatty liver despite constant body weight and composition, and also inflammation redu…

Similar experience here on minimal dose of GLP-1. There is definitely something going on here other than "you are just losing weight and that's really why you are healthier". With my labs at my current weight you can not tell that I am a type 2 diabetic. Previously, when I was at this very same weight in the past - all my labs indicated I was prediabetic.

Could be just because you stopped eating bad food. Things improve dramatically once you limit your intake of industrialized food.

Re: Semaglutide linked to lower predicted dementia risk

#193

Post by jaggederest » Sat, Aug 15, 2026, 9:23 PM UTC

SubmarineClub wrote: post #167

OptionOfT wrote: post #158

Earlier quoted context omitted.

We're too soft on companies, but equally too hard on people who have a food addiction.

[flagged]

As someone who has experienced so many different sides of this, you have zero clue the degree to which your appetite and ability to suppress it is hormonal until you get hormonally compromised (and then fix it, in my case, happily)

Blaming individuals for a public health crisis affecting 40% of the population is absolutely silly. There are a lot of individuals like me, who overeat behaviorally, but that doesn't explain the scale of the issue. maybe 8-10% of the population has some sort of eating disorder, the other 30% are just regular people eating an american diet.

Re: Semaglutide linked to lower predicted dementia risk

#194

Post by apparent » Sat, Aug 15, 2026, 9:24 PM UTC

llm_nerd wrote: post #156

apparent wrote: post #135

Earlier quoted context omitted.

Feel free to elaborate on my alleged insincerity. Was I insincere in noticing that there are partisan patterns at play, or insincere when pointing out that the govt should have more control over govt-run/taxpayer funded programs, as opposed to transactions between private parties? I am sincerely curious to know your opinion.

[flagged]

How does any of this make my comment insincere? Even if I agreed with it, I wouldn't understand how it proves your original accusation.

I also don't love your injection of flame-bait racial comments, which probably violate HN guidelines.

Re: Semaglutide linked to lower predicted dementia risk

#195

Post by kwanbix » Sat, Aug 15, 2026, 9:30 PM UTC

lotsofpulp wrote: post #104

kwanbix wrote: post #52

Earlier quoted context omitted.

Well, if you consider that is much cheaper to eat trash than healthy, and that food companies' only interest is in maximizing profit, you have what we have.

This is not true. Legumes/dairy/spices/vegetables are cheaper than boxed foods. Only question is do you want to spend 1 hour making it and cleaning up.

You are missing the protein.

Re: Semaglutide linked to lower predicted dementia risk

#196

Post by apparent » Sat, Aug 15, 2026, 9:43 PM UTC

llm_nerd wrote: post #156

apparent wrote: post #135

Earlier quoted context omitted.

Feel free to elaborate on my alleged insincerity. Was I insincere in noticing that there are partisan patterns at play, or insincere when pointing out that the govt should have more control over govt-run/taxpayer funded programs, as opposed to transactions between private parties? I am sincerely curious to know your opinion.

[flagged]

Replying to your edit:

Amazing that you again allege insincerity, with zero evidence. You then go on to make false claims about what I said and avoid the obvious point that my problem is not with the historical figure that you quoted, but the fact that you injected race into a conversation that was about food.

As for whether you violate the HN guidelines, the number of your recent comments that are greyed out tends to indicate that I'm not the only one who thinks you're out of step here.

Re: Semaglutide linked to lower predicted dementia risk

#197

Post by amelius » Sat, Aug 15, 2026, 9:44 PM UTC

miki123211 wrote: post #115

I swear, Semaglutide is reverse Asbestos. It's something we found and started using to one specific problem, but it later turned out that it has lots of other, extremely wide-ranging consequences. Except that in this case, these consequences are positive.

Semaglutide reduces appetite. Who could have known that eating less will have positive effects?

Maybe we should try consuming less in general and see what the effects are. Is there a semaglutide for my shopping habits? Maybe ban ads?

Re: Semaglutide linked to lower predicted dementia risk

#198

Post by lotsofpulp » Sat, Aug 15, 2026, 9:49 PM UTC

kwanbix wrote: post #195

lotsofpulp wrote: post #104

Earlier quoted context omitted.

This is not true. Legumes/dairy/spices/vegetables are cheaper than boxed foods. Only question is do you want to spend 1 hour making it and cleaning up.

You are missing the protein.

Eggs and legumes and yogurt and milk and tofu have protein. And chicken isn’t that expensive.

Re: Semaglutide linked to lower predicted dementia risk

#199

Post by weberer » Sat, Aug 15, 2026, 9:49 PM UTC

llm_nerd wrote: post #156

apparent wrote: post #135

Earlier quoted context omitted.

Feel free to elaborate on my alleged insincerity. Was I insincere in noticing that there are partisan patterns at play, or insincere when pointing out that the govt should have more control over govt-run/taxpayer funded programs, as opposed to transactions between private parties? I am sincerely curious to know your opinion.

[flagged]

You obviously do not know what the word "sincere" means. Please look it up before posting further.

Re: Semaglutide linked to lower predicted dementia risk

#200

Post by JimRoepcke » Sat, Aug 15, 2026, 9:51 PM UTC

Semaglutide reduces appetite.

The less appetite you have the less you eat crap. The less crap you eat the healthier you are.

There's a little more to it than that obviously but this is the reason that they're finding all these "unexpected" things improving when people take semaglutide. Most food eaten by most people with access to semaglutide is crap, that makes you unhealthy. Eating less crap improves lots of factors.

But the good news is, eating less crap makes you less unhealthy independent of other factors too.