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Semaglutide linked to lower predicted dementia risk

alz-journals.onlinelibrary.wiley.com

151–160 of 430 posts

Re: Semaglutide linked to lower predicted dementia risk

#151

So has anyone managed to separate the effects of semaglutide from the effects of weight loss? If this is caused by the weight loss, it is a little disappointing that public health didn't act quicker - lots of people have been overweight for a century now, so literally 10's of millions of people could have been saved from dementia had action been taken 100 years ago.

> So has anyone managed to separate the effects of semaglutide from the effects of weight loss?

In general? Yes. For this specific thing? We haven't even really shown the effects matter for humans.

> If this is caused by the weight loss, it is a little disappointing that public health didn't act quicker - lots of people have been overweight for a century now, so literally 10's of millions of people could have been saved from dementia had action been taken 100 years ago.

Public health has been banging the drum on obesity for decades now. But humans on the whole aren't built to be able to resist hyper palatable calorie dense cheap foods.

Re: Semaglutide linked to lower predicted dementia risk

#152

tdlr: This is a Novo Nordisk-funded study focusing on predictive biomarkers rather than real-world dementia cases. Novo Nordisk's actual dedicated clinical trials for Alzheimer's completely failed to show that semaglutide stops cognitive decline. "A predictive biomarker is like a "check engine" light on your dashboard. It warns you that there is a risk of a future problem. In this study, the researchers only checked…

Much appreciated post, but can you keep the AI slop separate from the rest of it?

Re: Semaglutide linked to lower predicted dementia risk

#153
post #97

Earlier quoted context omitted.

And have a real conversation around Corn syrup. Even today, a Soda with 'real sugar', at least for me, is far more satiating for thirst or a 'quick sweet treat' than the same brand/'flavor' using corn syrup, that includes both the big chains as well as the local names. If I drink a soda with sugar in it, I usually wind up wanting water after. If I drink something with corn syrup, I usually just want more of whatever…

Real sugar in your soda pop? What are you, a health nut? Must be a real my body is a temple sort. Seriously though, it's a dogshit thing to consume whether it is sweetened with HFCS or sucrose. "Even today, a Soda with 'real sugar', at least for me, is far more satiating" Did you know that in the acidic environment of a cola, sucrose quickly degrades into fructose and glucose (and if it didn't, your enzymes literally…

The idea that there’s some magic ingredient that makes soda a healthy choice is why discussion of “Junk food” Is so weird

Re: Semaglutide linked to lower predicted dementia risk

#154

I'm a big semaglutide proponent after being on it for a year. I know research says it helps with inflammation, arthritis (separately from weight reduction), and all sorts of magical things. I lost 40 pounds in a year(230 to 190) at age 50. Great! I also went from being active and fat(weightlifting with some cardio) to basically having no energy. In the last year I've had arthritis appear in several joints. I'm awake…

I'm younger than you and only loss a about 25 lbs. I've now gone to a maintenance dose and seen my energy recover substantially, I do still think (anecdotally) that when I got off for a week I got even more energy but it's hard to judge.

Re: Semaglutide linked to lower predicted dementia risk

#155

Earlier quoted context omitted.

Fructose is blood sugar invisible, and plays no part in this conversation. Fructose can cause fatty liver and has been attributed with lots of voodoo, but the weird fructose focus of some is not evidence based. It's nonsense. "The medical establishment and big pharma simple ignores the fact " Do you really think the "medical establishment" hasn't been *screaming* about poor diets for decades? The fact that people ign…

> Fructose can cause fatty liver It is also a large contributor to rising triglycerides levels and uric acid due to the way it is metabolized. Which in turn contributes to high blood pressure. It also makes Acetyl-CoA, which stimulates lipogenesis. It is not even true that it is 'blood sugar invisible'. 30-50% of the fructose is converted in glucose and that's visible. The rest won't be available until you start burn…

>The world didn't suddenly decide to get less active all of a sudden

In many ways, yes it did. There is a shocking decline in active calories in every developed country, and it has been exported to the developing world as well. People are astonishingly lazy, on the average.

Like, Christ, it's so bad that the recommendation to take a brief, slow walk after meals is revolutionary now. Because the average person just waddles to their chair and then "digests". It is astonishing how lazy the average person is in many countries.

>It has to be really high. We are talking about hours to burn up that bowl of frosted flakes.

I love that you declare that I'll be "in for a surprise", as if you're educating me. Hilarious stuff.

In any case, really high is...a bit of an exaggeration. I cycled 30km this morning, at the crack of dawn. A fairly casual, 20km/h or so ride down to the lake and back. That's an estimated 900 calories, or about three bowls of frosted flakes with milk. And the fun thing is that I didn't even eat this morning and did it purely on glucose reserves. This wasn't some athletic thing and was very much a casual "catch the end of summer" thing. Actual athletes absolutely destroy those numbers. People engaged in basic recreational sports destroy those numbers.

And that bike ride is something people would do just getting to and from places in the not to distant past. Where people were constantly moving and doing. Now most of the readers of this comment will have done nothing today beyond moving from seat to seat in various transporters and digestion chambers.

We've all been around someone who is spectacularly lazy who'll tell you about their "metabolism", and who'll jealously jeer when a peer eats without concern and somehow stays healthy. In the vast majority of cases, the latter person is active in their life, and the former person is one of those seat-to-seat people. Being active impacts every facet of your life, and endless choices throughout the day, and it yields an enormous impact on your health.

edit: meant to address the fructose. The fructose converted to glucose does so slowly enough that there is a marginal impact on blood sugar. And the average person consumes multiples more glucose than fructose. Should people consume less fructose (ergo sugar, even if the current admin is trying to healthwash sucrose)? Absolutely. But glucose and simple carbs are the biggest vehicle towards blood sugar and overwhelming glucose reserves.

Re: Semaglutide linked to lower predicted dementia risk

#156

Earlier quoted context omitted.

This is a pretty insincere take.

Feel free to elaborate on my alleged insincerity. Was I insincere in noticing that there are partisan patterns at play, or insincere when pointing out that the govt should have more control over govt-run/taxpayer funded programs, as opposed to transactions between private parties? I am sincerely curious to know your opinion.

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Re: Semaglutide linked to lower predicted dementia risk

#157

Earlier quoted context omitted.

My assumption was that GLP-1's don't suppress appetite so much as suppress the compulsion to eat when not necessary/more than necessary?

They also clearly have some impacts on metabolism. It’s well known that a challenge with dieting isn’t just eating less, it’s metabolic changes that make weight loss harder. GLP-1’s avoid that.

They do slow down the metabolism, yes.

They seem to also act on some reward mechanism - making some stuff (not just food. Alcohol, gambling, porn, smoking, other drugs have anecdotally been reported to feel less attractive / addictive) have a reduced pull on one's will. They also measurably delay gastric emptying - to the point that some medicines, meant to be taken on an empty stomach, are not safe to take within up to 3 hours from the last meal, compared to one hour or so for other people.

Re: Semaglutide linked to lower predicted dementia risk

#158

So has anyone managed to separate the effects of semaglutide from the effects of weight loss? If this is caused by the weight loss, it is a little disappointing that public health didn't act quicker - lots of people have been overweight for a century now, so literally 10's of millions of people could have been saved from dementia had action been taken 100 years ago.

> So has anyone managed to separate the effects of semaglutide from the effects of weight loss? In general? Yes. For this specific thing? We haven't even really shown the effects matter for humans. > If this is caused by the weight loss, it is a little disappointing that public health didn't act quicker - lots of people have been overweight for a century now, so literally 10's of millions of people could have been sa…

We're too soft on companies, but equally too hard on people who have a food addiction.

Re: Semaglutide linked to lower predicted dementia risk

#159

Earlier quoted context omitted.

> Fructose can cause fatty liver It is also a large contributor to rising triglycerides levels and uric acid due to the way it is metabolized. Which in turn contributes to high blood pressure. It also makes Acetyl-CoA, which stimulates lipogenesis. It is not even true that it is 'blood sugar invisible'. 30-50% of the fructose is converted in glucose and that's visible. The rest won't be available until you start burn…

>The world didn't suddenly decide to get less active all of a sudden In many ways, yes it did . There is a shocking decline in active calories in every developed country, and it has been exported to the developing world as well. People are astonishingly lazy, on the average. Like, Christ, it's so bad that the recommendation to take a brief, slow walk after meals is revolutionary now. Because the average person just w…

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Re: Semaglutide linked to lower predicted dementia risk

#160

Earlier quoted context omitted.

People kick around the idea of the "personal fat threshold". E.g. caucasians seem to be better at carrying fat than, say, Southeast Asians. White people seem to be able to better store fat without metabolic side effects; SEA seems to get T2D at a much lower bodyfat percentage.

Possibly maybe, but plenty of caucasian friends at my old bodyweight/fat percentage had/have horrible markers. I lean more towards the protective effect of exercise.

Agree 100%. To quote myself:

---

Which do you think is worse: smoking, or not exercising?

https://jamanetwork.com/journals/jamanetworkopen/fullarticle...

Look at Figure 2C in particular. The hazard ratio of smoking is 1.41. The hazard ratio between "Low" (In other words, it is better to be a smoker than in the lower 25% of non-exercisers. By far. It's not even close.

https://news.ycombinator.com/item?id=40080849

Let me emphasize: that exercise hazard ratio is between LOW and BELOW-AVERAGE.

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