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Semaglutide linked to lower predicted dementia risk

alz-journals.onlinelibrary.wiley.com

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Re: Semaglutide linked to lower predicted dementia risk

#11

Post by mapontosevenths »

ndr wrote: post #7
AFF87 wrote: post #3

We are very early in the semaglutide world, exciting times ahead!

For sure we still need to find out many related outcomes. Last year it become known that it increases (high relative risk, low absolute risk) non-arteritic anterior ischemic optic neuropathy (NAION), ie sudden, sometimes permanent vision loss. https://www.ema.europa.eu/en/news/prac-concludes-eye-conditi...

To save others the click: It increased the likelihood to 1 in 10,000 in adults with type 2 diabetes.

Diabetics are already more prone NAION. This studies contribution was to show that diabetics on GLP-1's are MORE prone. It does not show that the general population is more prone when taking GLP-1's.

I didn't check to see if other studies prove that.

Re: Semaglutide linked to lower predicted dementia risk

#12

Post by thrtythreeforty »

mapontosevenths wrote: post #11
ndr wrote: post #7

Earlier quoted context omitted.

For sure we still need to find out many related outcomes. Last year it become known that it increases (high relative risk, low absolute risk) non-arteritic anterior ischemic optic neuropathy (NAION), ie sudden, sometimes permanent vision loss. https://www.ema.europa.eu/en/news/prac-concludes-eye-conditi...

To save others the click: It increased the likelihood to 1 in 10,000 in adults with type 2 diabetes. Diabetics are already more prone NAION. This studies contribution was to show that diabetics on GLP-1's are MORE prone. It does not show that the general population is more prone when taking GLP-1's. I didn't check to see if other studies prove that.

It is well known that forcing a sudden drop in chronically high average blood glucose (like, from 200+ to a normal ish range) with insulin can cause vision loss. I wonder if it's the same mechanism?

Re: Semaglutide linked to lower predicted dementia risk

#13

Post by diath »

toomuchtodo wrote: post #4
randycupertino wrote: post #2

This is interesting. Diabetes is a well-known risk factor for dementia.

Western disease and sugar heavy diets broadly speaking, which Semaglutide is a countermeasure against. Not yet a vaccine, but in due time (probably via gene therapy). Fructose also helps cancer metastases and spread. https://www.sciencealert.com/common-sugar-appears-to-loosen-...

> Western disease and sugar heavy diets broadly speaking

No, just being sedentary. There's no such thing as acquired diabetes in physically active people.

Re: Semaglutide linked to lower predicted dementia risk

#14

Post by Scharkenberg »

Alien1Being wrote: post #8

"Semaglutide attenuates a proteomics-based dementia risk signature " ie : clinically meaningless. The company behind this, Novo Nordisk is increasingly desperate, as tirzepatide destroys the semaglutide revenue stream and the consequent job losses decimate the company

Can you elaborate on your claims? As it currently stands, I’m only reading meaningless drivel from you.

Re: Semaglutide linked to lower predicted dementia risk

#15

Post by tptacek »

Alien1Being wrote: post #9
toomuchtodo wrote: post #4

Earlier quoted context omitted.

Western disease and sugar heavy diets broadly speaking, which Semaglutide is a countermeasure against. Not yet a vaccine, but in due time (probably via gene therapy). Fructose also helps cancer metastases and spread. https://www.sciencealert.com/common-sugar-appears-to-loosen-...

[flagged]

I don't see anything RFK-like in that comment.

Re: Semaglutide linked to lower predicted dementia risk

#18

Post by tptacek »

ndr wrote: post #7
AFF87 wrote: post #3

We are very early in the semaglutide world, exciting times ahead!

For sure we still need to find out many related outcomes. Last year it become known that it increases (high relative risk, low absolute risk) non-arteritic anterior ischemic optic neuropathy (NAION), ie sudden, sometimes permanent vision loss. https://www.ema.europa.eu/en/news/prac-concludes-eye-conditi...

In addition to being closely associated with the conditions semaglutide treats, NAION is quite rare.

Re: Semaglutide linked to lower predicted dementia risk

#20

Post by adjejmxbdjdn »

toomuchtodo wrote: post #4
randycupertino wrote: post #2

This is interesting. Diabetes is a well-known risk factor for dementia.

Western disease and sugar heavy diets broadly speaking, which Semaglutide is a countermeasure against. Not yet a vaccine, but in due time (probably via gene therapy). Fructose also helps cancer metastases and spread. https://www.sciencealert.com/common-sugar-appears-to-loosen-...

First of all it’s a nice study. The dosages they always give are way too high and mice are rarely a reliable model.

But you’re also ignoring the fact that the same study shows that glucose inhibits the behavior.

So your claim that the study indicates its sugar is incorrect. The study indicates a possible impact from fructose which is countered by glucose, so the real issue is the fructose to glucose ratio.

Table sugar providing equal fructose and glucose molecules is acquitted by this study.

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