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Drug reverses autism-like brain changes in adult mice within hours

uclahealth.org

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Re: Drug reverses autism-like brain changes in adult mice within hours

#31
post #19

Earlier quoted context omitted.

> I see this sentiment often, but only when it comes to autism. How is this different from other disorders, disabilities, illnesses? These are not equivalent, synonymous terms. I think that your premise might need some work. There's plenty of people in the world who are healthy, autistic, and not disabled at all.

I know they're not synonymous, that's why I used all 3 and not just one.

That may be what was meant, but that's not how it was written.

Re: Drug reverses autism-like brain changes in adult mice within hours

#32

Being autistic myself, I feel conflicted about trying to "cure autism" Every day is challenging because I have to manage my energy, mask in social situations and at work, etc On the other hand, I like who I am and I'm also very good at what I do because my brain is structured the way it is. I can imagine a society that is structured in a way, where I don't need the accommodations I'm currently dependent on If the neg…

I see this sentiment often, but only when it comes to autism. How is this different from other disorders, disabilities, illnesses? You could make the exact same arguments for blindness. Every day is challenging, difficulties are mostly a consequence of how we've structured society, it's other people who should accommodate those who have different needs, etc. This narrative seems to originate from, and is perpetuated…

> How is this different from other disorders, disabilities, illnesses?

Not diagnosed autistic myself, but I buy into the argument that a lot of “(mental) disorders” make one allergic to the amount of subtle and less subtle daily dose of interrelational violence. Plenty of drugs exist to numb organisms.

I don’t know if you’ve ever been on antidepressants or antipsychotics, but one who has might relate that that kind of “cure” means to turn you into a “functioning zombie”. One may prefer the suffering and ability to fight and point out violent behavior rather than a medically-induced zoning out.

Our societies are far from “healthy”. What is “disordered” is how we treat ourselves and others. It’s up to each one individually to decide how much they want to be part of this “normal” or whether they prefer to be “disordered” even if it comes with certain limitations.

”It Is No Measure of Health To Be Well-Adjusted to a Profoundly Sick Society” (Krishnamurti)

See e.g. Hughes, K., Bellis, M. A., Hardcastle, K. A., Sethi, D., Butchart, A., Mikton, C., Jones, L., & Dunne, M. P. (2017). The effect of multiple adverse childhood experiences on health: A systematic review and meta-analysis. The Lancet Public Health, 2(8), e356–e366. https://doi.org/10.1016/S2468-2667(17)30118-4

Re: Drug reverses autism-like brain changes in adult mice within hours

#33

Earlier quoted context omitted.

I see this sentiment often, but only when it comes to autism. How is this different from other disorders, disabilities, illnesses? You could make the exact same arguments for blindness. Every day is challenging, difficulties are mostly a consequence of how we've structured society, it's other people who should accommodate those who have different needs, etc. This narrative seems to originate from, and is perpetuated…

> How is this different from other disorders, disabilities, illnesses? Not diagnosed autistic myself, but I buy into the argument that a lot of “(mental) disorders” make one allergic to the amount of subtle and less subtle daily dose of interrelational violence. Plenty of drugs exist to numb organisms. I don’t know if you’ve ever been on antidepressants or antipsychotics, but one who has might relate that that kind o…

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Re: Drug reverses autism-like brain changes in adult mice within hours

#34
post #22

Earlier quoted context omitted.

Possibly, possibly not. Bryan Johnson took it for 5 years in an attempt to slow aging. He eventually discontinued because it was causing an increase in skin infections (as you'd expect from an immune system suppressant), but cycling could mitigate that.

Regardless of side effects there is no reliable evidence that rapamycin slows aging in humans.

What the fuck is the point of this commemt? Like what are you even insinuating? Half the drugs in the world have dubious evidence. U bafoon

Re: Drug reverses autism-like brain changes in adult mice within hours

#35
post #28
post #22

Earlier quoted context omitted.

Regardless of side effects there is no reliable evidence that rapamycin slows aging in humans.

Would we have evidence even if it was true?

What do you mean? Population control?

Re: Drug reverses autism-like brain changes in adult mice within hours

#36

Earlier quoted context omitted.

I see this sentiment often, but only when it comes to autism. How is this different from other disorders, disabilities, illnesses? You could make the exact same arguments for blindness. Every day is challenging, difficulties are mostly a consequence of how we've structured society, it's other people who should accommodate those who have different needs, etc. This narrative seems to originate from, and is perpetuated…

> How is this different from other disorders, disabilities, illnesses? Part of the confusion here is that autism isn't straightforwardly a disability. A plurality of people with autism are ASD-1, which is the kind requiring the least support needs while, purely empirically speaking, conferring lots of well-documented benefits. The sort of elephant in the room in these conversations is that there are lots of replicabl…

I agree up until this point:

> The idea of attempting to engineer the removal of a class of people from society-- people with unique strengths which are necessary for the functioning of that society-- has consequences that are significantly less well-understood than proponents of this idea make it out to be.

I'll be the first to pick up my pitchforks at anyone who suggests non-consensual treatments. My point is that trying to find a cure for something is different from trying to eradicate people from a gene pool.

In fact, I would assume that having an effective treatment/cure for autism would make it more widespread, not less. People who were cured of their ASD-related deficits would be far more likely to find a partner and have kids, and those kids would inherit genes which are responsible for ASD.

Re: Drug reverses autism-like brain changes in adult mice within hours

#37
post #31

Earlier quoted context omitted.

I know they're not synonymous, that's why I used all 3 and not just one.

That may be what was meant, but that's not how it was written.

It was written fine. ASD is a disorder which was the first item on that list. You could make the same type of argument about disabilities (e.g. deafness) and someone pointed out that people make the same arguments in the deaf community too.

Re: Drug reverses autism-like brain changes in adult mice within hours

#38

Being autistic myself, I feel conflicted about trying to "cure autism" Every day is challenging because I have to manage my energy, mask in social situations and at work, etc On the other hand, I like who I am and I'm also very good at what I do because my brain is structured the way it is. I can imagine a society that is structured in a way, where I don't need the accommodations I'm currently dependent on If the neg…

I see this sentiment often, but only when it comes to autism. How is this different from other disorders, disabilities, illnesses? You could make the exact same arguments for blindness. Every day is challenging, difficulties are mostly a consequence of how we've structured society, it's other people who should accommodate those who have different needs, etc. This narrative seems to originate from, and is perpetuated…

treating the dsm like a checklist of cures to complete sounds a bit like what might go in the dsm

Re: Drug reverses autism-like brain changes in adult mice within hours

#39
post #21

Being autistic myself, I feel conflicted about trying to "cure autism" Every day is challenging because I have to manage my energy, mask in social situations and at work, etc On the other hand, I like who I am and I'm also very good at what I do because my brain is structured the way it is. I can imagine a society that is structured in a way, where I don't need the accommodations I'm currently dependent on If the neg…

The flip side - I don't think there's a single upside to the ASD traits I have, I don't like myself, and I would absolutely love to know what it feels like to not have ASD.

I think it'd be neat to be able to switch it off temporarily.

One of my greatest strengths is diving deeply into unfamiliar technical rabbit holes that relate to my own innate areas interest, and get useful results quickly. This is a quality that separates me from most others and I enjoy doing this when the opportunity arises. But I can't necessarily turn it off; I don't always get a choice about whether I'm going to be diving into a thing or not.

Overall, I think this has has been a valuable set of traits.

But my greatest weaknesses are...just about everything else. For stuff that is outside of the subset of things that are innately interesting, I often find them difficult to grasp. It can be challenging to get my head around some stuff that many others can do without much effort at all. I can usually get there eventually; it just always takes more work for me than it would for a more-typical person, and I don't necessarily learn them in the same ways that a normal person might.

It'd be fun to see how the world would work for me if these qualities were averaged out, but long-term it would mean that many aspects of my life would have to be shaped very differently. Therefore, I would not want it to be permanent without first spending some time visiting the other side of the fence.

Re: Drug reverses autism-like brain changes in adult mice within hours

#40

Earlier quoted context omitted.

I see this sentiment often, but only when it comes to autism. How is this different from other disorders, disabilities, illnesses? You could make the exact same arguments for blindness. Every day is challenging, difficulties are mostly a consequence of how we've structured society, it's other people who should accommodate those who have different needs, etc. This narrative seems to originate from, and is perpetuated…

treating the dsm like a checklist of cures to complete sounds a bit like what might go in the dsm

If you try to reformulate that snarky one-liner that into a good faith argument you'll see how ridiculous it sounds.

Yes, actually we should have treatments and cures available for anyone who wants them, for anything inside and outside the DSM.

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