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Why DNA damage from smoking and UV rays cause cancer in some but not others

cam.ac.uk

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Re: Why DNA damage from smoking and UV rays cause cancer in some but not others

#11

Post by Noaidi »

This is why Zinc is needed to prevent cancer[1].

The gene they are focusing on in the study [2] is Methylated-DNA--protein-cysteine methyltransferase (MGMT) and it needs zinc as a cofactor [3].

Not enough zinc, lower MGMT, and less DNA protection and repair.

Nutritional deficiencies and genetic differences increase the risk of cancer.

[1] https://link.springer.com/article/10.1007/s12011-023-03818-6 [2] https://www.nature.com/articles/s41586-026-10821-z [3] https://www.uniprot.org/uniprotkb/P16455/entry

Re: Why DNA damage from smoking and UV rays cause cancer in some but not others

#12

Post by Noaidi »

doctoboggan wrote: post #7

Isn't this sort of like asking "Why does getting shot kill some but not other?" It depends on which part of the body was shot, and which part of the DNA was damaged.

No. Genetics and nutrition make a big difference here. It is like one person is wearing a bullet proof vest and both were shot in the same place.

Re: Why DNA damage from smoking and UV rays cause cancer in some but not others

#13

Post by bob1029 »

aantix wrote: post #3

Anecdotally, whenever I go swimming with my kids in the summer, and I don't put sunscreen on right away, but let myself get some intense direct sun, I feel good and sleep really well that night. As long as I don't let myself get in a red, sunburn situation.

I can spend a solid hour in the sun before I start to burn, assuming I have a hat on my head.

I've also noticed some correlation between my diet and how fast I burn. Whenever my metabolism is running at/near ketogenesis, it seems like it takes a lot longer for the sun to affect me.

Re: Why DNA damage from smoking and UV rays cause cancer in some but not others

#14

Post by htek »

JoeAltmaier wrote: post #2

In mice

Mice are used for inhalation and skin studies because they're cheap, we know their genome, they have a short lifespan for whole lifecycle observation and they're ideal for mapping to human respiratory and skin responses.

Re: Why DNA damage from smoking and UV rays cause cancer in some but not others

#15

Post by [deleted] »

ThrowawayTestr wrote: post #5
aantix wrote: post #3

Anecdotally, whenever I go swimming with my kids in the summer, and I don't put sunscreen on right away, but let myself get some intense direct sun, I feel good and sleep really well that night. As long as I don't let myself get in a red, sunburn situation.

Vitamin D deficiency

[deleted]

Re: Why DNA damage from smoking and UV rays cause cancer in some but not others

#17

Post by mr_mitm »

doctoboggan wrote: post #7

Isn't this sort of like asking "Why does getting shot kill some but not other?" It depends on which part of the body was shot, and which part of the DNA was damaged.

The way I read the article was that cancer is caused by deficiencies in the body's repair mechanism. It appears as if some have a more robust mechanism than others, depending on genetics.

Re: Why DNA damage from smoking and UV rays cause cancer in some but not others

#18

Post by Ralfp »

bob1029 wrote: post #13
aantix wrote: post #3

Anecdotally, whenever I go swimming with my kids in the summer, and I don't put sunscreen on right away, but let myself get some intense direct sun, I feel good and sleep really well that night. As long as I don't let myself get in a red, sunburn situation.

I can spend a solid hour in the sun before I start to burn, assuming I have a hat on my head. I've also noticed some correlation between my diet and how fast I burn. Whenever my metabolism is running at/near ketogenesis, it seems like it takes a lot longer for the sun to affect me.

Yes, some stuff make your skin more sensitive to light than others. For example, you should avoid vitamin A creams and some herbs during summer because they increase risk of permanent skin discoloration.

Re: Why DNA damage from smoking and UV rays cause cancer in some but not others

#19

Post by add-sub-mul-div »

htek wrote: post #14
JoeAltmaier wrote: post #2

In mice

Mice are used for inhalation and skin studies because they're cheap, we know their genome, they have a short lifespan for whole lifecycle observation and they're ideal for mapping to human respiratory and skin responses.

These comments are filled with people who believe that everyone else here is dumber than they are. Leaving shallow dismissive comments explaining something that doesn't need to be explained is like crack to them.

Re: Why DNA damage from smoking and UV rays cause cancer in some but not others

#20

Post by krrrh »

aantix wrote: post #3

Anecdotally, whenever I go swimming with my kids in the summer, and I don't put sunscreen on right away, but let myself get some intense direct sun, I feel good and sleep really well that night. As long as I don't let myself get in a red, sunburn situation.

The number one reason I wear an Apple Watch all summer is the UV index complication. If the number is at 4 and trending down I let the kids run free.
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