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New HIV vaccine shows unprecedented success in preclinical study

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Re: New HIV vaccine shows unprecedented success in preclinical study

#231

Post by pibaker »

shadowtree wrote: post #207
dahinds wrote: post #201

Earlier quoted context omitted.

I don't think the original assertion is "punching down" on poor people. While you're correct that poverty isn't the "only reason" for high HIV transmission, poverty certainly contributes to it, via lack of access to health care and lack of access to education. How is it less "punching down" to attribute it to social behavior and culture? Isn't needle sharing associated with poverty, or would you also call that "cultu…

I was poor, grew up in social housing. I did not use drugs. "I share needles because I can't afford my own" is an INSANE take. Don't shoot drugs in the first place! Poor people are normal humans, they have willpower, agency. It is a rich people myth that poor people are cattle, devoid of any chance of doing the right thing. It is culture, behavior, social norms. Being poor does not force you to abandon the nuclear fa…

Thanks for your contribution. Gonna hop on a jet to Zambia tomorrow and tell kids with HIV there that it's their fault they were born with the virus and maybe they shouldn't have shared needles.

Re: New HIV vaccine shows unprecedented success in preclinical study

#232

Post by [deleted] »

tempfile wrote: post #86
jonathanlydall wrote: post #44

Earlier quoted context omitted.

You could say the same about teen pregnancy being a practically solved problem, except there is still the problem of teen pregnancy. Or even something more mundane as driving consistently safely all the time to solve the problem of accidents. If everyone was disciplined all the time in regard to everything, many problems in the world would simply not exist. But we live in reality where for whatever reason, people don…

Right, but we know that HIV/AIDS essentially is a solved problem in rich countries, that the mentioned interventions are readily available in rich countries, and the only reason HIV transmission is high in poor countries is because, well, they're poor. We (humanity as a whole) have plenty of money, we could fund these things, we simply choose not to. I would caution against making an allusion to self control. It woul…

[deleted]

Re: New HIV vaccine shows unprecedented success in preclinical study

#233

Post by cwillu »

shadowtree wrote: post #214
garciasn wrote: post #208

Earlier quoted context omitted.

Dry sex in SSA may be one of the contributing factors, but it’s never been truly proven out as a key contributor in any study I have read; they always address it but say more needs to be done to be certain. Your comment makes it seem like a key factor when it’s not.

In the Global Burden of Disease analyses, sub-Saharan Africa (SSA) had the highest age-standardized STI incidence rate of any world region — around 19,973 per 100,000 person-years, which is roughly double the global average of about 9,536 cases per 100,000. Forecasts to 2030 expect sub-Saharan Africa to continue having the highest incidence rates of both HIV and other STIs of any region. How come a specific region of…

It comes with the territory; IMO if you don't occasionally have a few comments go negative, you're probably not saying anything of value.

Re: New HIV vaccine shows unprecedented success in preclinical study

#234

Post by UltraSane »

nerdjon wrote: post #229
UltraSane wrote: post #69

Earlier quoted context omitted.

Are you arguing that all sexually active people should take prep?

I am arguing that all sexually active people (except maybe those in a fully confirmed monogamous relationship) should at a minimum have a conversation with their doctor about it and their doctor should bring it up. Maybe it isn't worth it for you in the end after that conversation, but we should also not assume that the only way you get HIV is through "risky" behavior. That is irresponsible. At least you would know i…

In developed nations like the US, health economic models estimate that deploying PrEP across generalized heterosexual groups costs anywhere from $150,000 to over $1 million per single HIV transmission prevented.

Re: New HIV vaccine shows unprecedented success in preclinical study

#235

Post by greazy »

Melatonic wrote: post #194
mrguyorama wrote: post #175

Earlier quoted context omitted.

HIV isn't the only virus that generates decoys to trick antibody development, so having techniques that bypass that decoy strategy is very useful.

What else does this?

I think all viruses do to some extent. We refer to them as DIPs https://en.wikipedia.org/wiki/Defective_interfering_particle

List includes RSV, flu, sc2 and of course hiv

Re: New HIV vaccine shows unprecedented success in preclinical study

#236

Post by nextaccountic »

simonask wrote: post #56
Telemakhos wrote: post #37

Earlier quoted context omitted.

[flagged]

Abstinence has been shown to be an extremely, hilariously, stupidly ineffective strategy in all questions of human sexual health. The HIV/AIDS epidemic would not have been nearly as serious as it was if people like you and the Catholic Church hadn’t advocated for it over all other measures. It doesn’t work. Change your mind.

I agree but asking your partners to get tested is not abstinence

Re: New HIV vaccine shows unprecedented success in preclinical study

#237

Post by nephihaha »

ck2 wrote: post #163

The timeline of HIV/AIDS discovery to treatment to "cure" is fascinating to me I distinctly remember Reagan cabinet members openly joking about all the people dying from it in WhiteHouse press briefing (basically Trump before Trump prototypes) * https://en.wikipedia.org/wiki/Timeline_of_HIV/AIDS Now if they could just do this for me-cfs/long-covid and related auto-immune diseases (there are over eighty) without the 5…

I knew someone who claimed they had encountered AIDS as a doctor in late 1960s London. I don't know the truth of this, of course, and the person concerned has passed away. I do know that some illnesses present similarly, but it's not impossible. I am sure these diseases are around for a while before people identify them properly.

Re: New HIV vaccine shows unprecedented success in preclinical study

#238

Post by bluGill »

nerdjon wrote: post #50
bluGill wrote: post #39

Earlier quoted context omitted.

I don't see how you are disagreeing. We are both saying that a lot more people are having risky sex than think they are.

I guess it depends on what we call risky, I mean if someone is actively trying to get pregnant are we considering that "risky"? Someone could be taking the necessary precautions and a mistake happens, a condom breaks, whatever. Someone could have sex with one person in their life and they got it from that person. I would not consider that "risky" in any real sense of the word. Any sex carries some amount of risk, and…

Someone trying to get pregnant is most likely to be low risk since odds are good they have a specific partner in mind and are having enough sex that they don't care to stray. Not always but in general

There are many pregnancies that result from one night stands and those are high risk, but only rarely was pregnancy a goal.

Also HIV spreads most often from anal sex. Someone trying to get pregnant is less likely to get HIV just because of how they are having sex and so lower risk. (Not zero though, don't rely on statistics with your life of your partner has HIV)

The topic here is HIV risk. Obviously getting pregnant requires unprotected sex, but the risk of HIV is about sex with someone who has it.

Re: New HIV vaccine shows unprecedented success in preclinical study

#239

Post by serf »

cj wrote: post #124
soco wrote: post #79

Earlier quoted context omitted.

All your arguments are sound, and I'm still missing your point. Pharma is interested in doing pharma, indeed. But who's interested in your solution, assuming you have one? A significant part of the current electorate (internationally, even) seems to abhor sex ed, condoms, abortions and all that. So tell me again please how you suggest we address teen pregnancy - in THIS world.

The person I was responding to says "HIV is not a solved problem" and "we need a new tool to solve it, a vaccine!" My argument is simply that new tools are great, but it's not what's going to solve the HIV problem. Distribution, cost, access, stigma, etc are the larger problems to deal with. (We need to solve all the reasons why people aren't using the existing tools)

people don't forego condoms in high income nations due to lack of access, distribution, cost, or stigma.

they make the experience measurably worse for a maybe insurance.

I don't know what fixes that reality other than (maybe?) mass-traumatizing youths with stories and photos of STI/HIV victims, essentially scaring them into wearing a rubber at the risk of scaring them out of sex entirely.

... which is why a vaccine sure would be nice.

Re: New HIV vaccine shows unprecedented success in preclinical study

#240

Post by tpolm »

fhdkweig wrote: post #33
RGS1811 wrote: post #3

While HIV vaccine research is an exciting field, it's worth pointing out that halting HIV transmission is, practically speaking, a solved problem with oral and injectable reverse transcriptase inhibitors. The ongoing loss of life and health due to HIV could be stopped if we cared enough to invest resources in wide-scale PrEP availability and public health education. Waiting for an HIV vaccine is the domain equivalent…

It is endemic in the simian population. It will keep crossing over into humans again and again. It has done it before several times. People who live near forests would have to be on Prep everyday of their lives. The reason they eat bushmeat is the because they are poor and will be too poor to afford daily medication. A once-and-done vaccine would at least stop new crossovers. Only then could we really get a handle on…

HIV did not exist in human population before XX centiry. Crossings from SIV are extremely rare - vaccinations is about HIV, not SIV
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