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New HIV vaccine shows unprecedented success in preclinical study

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Re: New HIV vaccine shows unprecedented success in preclinical study

#151

Post by shevy-java »

iandanforth wrote: post #20

The most interesting point of the article for me is that this vaccine appears to be a series of shots which act as a curriculum for the immune system. Each one slightly different and targeting a different stage of B-cell development. I've never thought of vaccine series working like that, so it was a new and impressive idea.

I do not see what is impressive here at all. The immune system constantly yields new antibodies targeting different epitopes - all the time. THAT is what is impressive, not multi-vaccines trying to induce shifts towards certain epitopes over others.

Re: New HIV vaccine shows unprecedented success in preclinical study

#152

Post by freeone3000 »

kstrauser wrote: post #130
SoftTalker wrote: post #52

Earlier quoted context omitted.

He doesn't have AIDS, he's HIV-positive.

I understand the difference between those statements, but confess that I'm not clear on the important distinction. Are there situations where untreated HIV doesn't progress to AIDS? Is the virus more transmissible in someone with AIDS than someone who's still at the HIV-positive stage? Asking here because I don't know, and I think an answer might help others know, too. (And to clarify, I genuinely don't know, and I'm…

We are unaware of any situations where HIV+ doesn’t turn into AIDS without treatment.

But being HIV+ is simply having a virus, not actively dying. HIV+ status also never clears - later tests that are “negative” mean your viral load is undetectable, at which point you can no longer transmit HIV to others. Undetectable = Untransmissable.

Re: New HIV vaccine shows unprecedented success in preclinical study

#153

Post by evilfred »

SoftTalker wrote: post #49
evilfred wrote: post #16

Earlier quoted context omitted.

prep is great but i would really rather take a one-time vaccine than be expected to take an expensive pill forever that could mess up my liver

Which one do you suppose the pharmaceutical companies would prefer?

who do you expect to create pharmaceuticals other than pharmaceutical companies? sheesh

Re: New HIV vaccine shows unprecedented success in preclinical study

#154

Post by tigerlily »

neonstatic wrote: post #108
Saline9515 wrote: post #89

Earlier quoted context omitted.

[flagged]

> But I guess that sex without condoms is worth it, right? Not speaking about LGBT related matters; Sex without condom is just like everything else - it depends on the person. For some people there is little to no difference. For others, wearing the condom removes all sensation, reducing the act to physical exercise. So is sex without condoms worth it? For some people, yes, it is.

And still others may be allergic to LaTeX.

Re: New HIV vaccine shows unprecedented success in preclinical study

#155

Post by [deleted] »

shevy-java wrote: post #151
iandanforth wrote: post #20

The most interesting point of the article for me is that this vaccine appears to be a series of shots which act as a curriculum for the immune system. Each one slightly different and targeting a different stage of B-cell development. I've never thought of vaccine series working like that, so it was a new and impressive idea.

I do not see what is impressive here at all. The immune system constantly yields new antibodies targeting different epitopes - all the time. THAT is what is impressive, not multi-vaccines trying to induce shifts towards certain epitopes over others.

[deleted]

Re: New HIV vaccine shows unprecedented success in preclinical study

#156

Post by wavemode »

cromka wrote: post #143
wavemode wrote: post #91

Earlier quoted context omitted.

It will have the opposite effect, if people who get the vaccine start behaving as though they are 100% protected (which, many people will).

> It will It might . You don't know that.

The epistemic modality of my statement was implied. I obviously don't know the future.

Re: New HIV vaccine shows unprecedented success in preclinical study

#157

Post by tonnydourado »

RGS1811 wrote: post #3

While HIV vaccine research is an exciting field, it's worth pointing out that halting HIV transmission is, practically speaking, a solved problem with oral and injectable reverse transcriptase inhibitors. The ongoing loss of life and health due to HIV could be stopped if we cared enough to invest resources in wide-scale PrEP availability and public health education. Waiting for an HIV vaccine is the domain equivalent…

Transportation was a solved problem with horses, doesn't mean the car isn't a good idea. Same for internal combustion and EVs.

A vaccine is an objectively better solution than PrEP, just because of the time scale, PrEP needs discipline on a daily or x-monthly basis. A vaccine could last for years. Although, realistically, it's more likely to end up requiring yearly updates like COVID, because HIV is also a mutating son of a bitch.

I 100% agree that waiting for a vaccine is stupid beyond measure. The world should do both: make PrEP widely available AND keep funding vaccine research.

Re: New HIV vaccine shows unprecedented success in preclinical study

#158

Post by freeone3000 »

gadders wrote: post #19
smcg wrote: post #18

Earlier quoted context omitted.

Those on prep would welcome a vaccine, it would be a significant improvement. I agree that this is no reason to take the foot off the gas with prep availability, we need more ASAP.

Is it not available in pharmacies?

Very dependent on locality. Mine requires a prescription for every refill, and I must continually meet certain risk criteria to qualify.

Re: New HIV vaccine shows unprecedented success in preclinical study

#160

Post by leptons »

RGS1811 wrote: post #3

While HIV vaccine research is an exciting field, it's worth pointing out that halting HIV transmission is, practically speaking, a solved problem with oral and injectable reverse transcriptase inhibitors. The ongoing loss of life and health due to HIV could be stopped if we cared enough to invest resources in wide-scale PrEP availability and public health education. Waiting for an HIV vaccine is the domain equivalent…

This isn't just about HIV, it's about finding new ways to approach viruses. HIV wasn't the first and won't be the last virus we don't have a way to stop. This research adds to our knowledge about ways to attack some of the trickier viruses.
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