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How to survive boiling water

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Re: How to survive boiling water

#51

Post by tippa123 »

weinzierl wrote: post #46
fnands wrote: post #40

Earlier quoted context omitted.

> it was the bioburden load of a media component and water temperature used during compounding. In English, please ;-)

I put it in AI and even that couldn't fix the sentence sufficiently for me to understand it completely. "So, in ordinary language:" "One dirty raw ingredient introduced far more spores than expected, and the way it was mixed into the water made the sterilization cycle less effective against them. The autoclave itself was probably not broken." "The exact relationship to water temperature remains somewhat ambiguous bec…

To be fair I omitted some key information. The 'dirty raw ingredient' mixed in room-temperature purified water wasn't sterilisable. The same process but mixed in 60°C purified water was sterilisable.

Re: How to survive boiling water

#52

Post by dotancohen »

weinzierl wrote: post #46
fnands wrote: post #40

Earlier quoted context omitted.

> it was the bioburden load of a media component and water temperature used during compounding. In English, please ;-)

I put it in AI and even that couldn't fix the sentence sufficiently for me to understand it completely. "So, in ordinary language:" "One dirty raw ingredient introduced far more spores than expected, and the way it was mixed into the water made the sterilization cycle less effective against them. The autoclave itself was probably not broken." "The exact relationship to water temperature remains somewhat ambiguous bec…

It actually took me a minute to decide whether or not to upvote the AI-content post. But it was informative, you were forthcoming on the origin, and the GP has yet to elaborate. Thank you for posting that.

Re: How to survive boiling water

#53

Post by dotancohen »

cobbzilla wrote: post #48
weberer wrote: post #25

Spore forming bacterium are notoriously resistant to most ways of killing them. There's even a species that can resist radiation amounts that are 1000x the dose needed to kill a human. https://en.wikipedia.org/wiki/Deinococcus_radiodurans

I want this mutation. You have little nano-crawlers going up and down your DNA strands fixing problems. It’s like ECC RAM for the essence of YOU. And you’re basically immune to cancer.

That is not how spores work.

Re: How to survive boiling water

#55

Post by Schiendelman »

roughly wrote: post #44
cratermoon wrote: post #2

This almost throwaway line from the article struck me as an example of what we can do with technology, if we choose to put our billions of dollars towards it: "I downloaded the BC30 genome".

It's a shame it became such a weird political football, because the story of the mRNA COVID vaccine is absolutely in the "we are as gods" pantheon - the virus was sequenced, and 3 days later two separate labs had sequences for the vaccine. Phase 1 trials began within 3 months. To go from "weird novel pathogen" to "enough engineered vaccine candidate to start Phase 1 trials" is some legitimate sci-fi shit.

Thankfully the political football is simmering down - I think we have mRNA flu vaccines in progress now, and attempts to stop that failed.

Re: How to survive boiling water

#56

Post by Andrex »

dotancohen wrote: post #53
cobbzilla wrote: post #48

Earlier quoted context omitted.

I want this mutation. You have little nano-crawlers going up and down your DNA strands fixing problems. It’s like ECC RAM for the essence of YOU. And you’re basically immune to cancer.

That is not how spores work.

Let the man dream (and possibly write interesting scifi about it).

Re: How to survive boiling water

#57

Post by gtowey »

triceratops wrote: post #26

Fascinating post. Why did the author steep the tea at home? "It was at this point I realized I needed a sterile-ish way to transport the steeped tea and tea bags from my house to the lab." Was steeping the tea at home somehow relevant to the experiment?

If I had to guess, it would be because that's exactly the environment and process that consumers will use, so it would capture variables such as "what if the probiotic was out-competed by a bacteria living on your mug?"

And then I would assume the sterile transfer was to preserve this state of the tea as-made without changing it on the way to the lab.

Re: How to survive boiling water

#58

Post by neonstatic »

cobbzilla wrote: post #48
weberer wrote: post #25

Spore forming bacterium are notoriously resistant to most ways of killing them. There's even a species that can resist radiation amounts that are 1000x the dose needed to kill a human. https://en.wikipedia.org/wiki/Deinococcus_radiodurans

I want this mutation. You have little nano-crawlers going up and down your DNA strands fixing problems. It’s like ECC RAM for the essence of YOU. And you’re basically immune to cancer.

> It’s like ECC RAM for the essence of YOU

Buddha would like a word with you

Re: How to survive boiling water

#59

Post by neonstatic »

Schiendelman wrote: post #55
roughly wrote: post #44

Earlier quoted context omitted.

It's a shame it became such a weird political football, because the story of the mRNA COVID vaccine is absolutely in the "we are as gods" pantheon - the virus was sequenced, and 3 days later two separate labs had sequences for the vaccine. Phase 1 trials began within 3 months. To go from "weird novel pathogen" to "enough engineered vaccine candidate to start Phase 1 trials" is some legitimate sci-fi shit.

Thankfully the political football is simmering down - I think we have mRNA flu vaccines in progress now, and attempts to stop that failed.

I was a conscious adult when all that was going down, so I can remind you, that on top of standard lunacy, there were legitimate concerns about safety of injecting something novel and untested to large parts of the population, genuine collusion to get as many people as possible injected, harassment that went both ways, and last but not least, there were many people who took one of the many vaccines and had life crushing, incurable side effects, not even mentioning the ones who died.

So the "political football" characterization is itself very political.

Re: How to survive boiling water

#60

Post by jzelinskie »

carschno wrote: post #21

People interested in this: if you are ever in Amsterdam, I recommend to visit the Micropia museum: https://www.artis.nl/en/artis-micropia Among many stunning things, they have a shelf full of foods and drinks (behind glasses) with age labels, ranging from days to years. It is fascinating to see how they evolve over time.

Love this museum! It's child and adult friendly. They also have the best souvenir: a collab with a local brewery for wild ales (sour beer)!
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