Tl;dr: think hard about what you’d use this much RAM for in a desktop setting and do some research about how people like the 395 for your use case. Not all use cases work well.
Anyone who thinks they are going to serve some 100+ GB LLM locally, remember that memory bandwidth becomes a key limitation for large models. While you might be able to load a model, token generation can be very slow. MoE models like Qwen3.5-122B-A10B work decently fast, but dense models of a decent size are slow and you won’t want to use them.
I’ve got a 395 system, and found that I’m quite happy with Qwen3.6-35B-A3B, generating at around 50 t/s, but the dense 27B model is 20-25 t/s and that’s the lower limit I’m willing to tolerate. So a 70b dense model is just not going to happen. That means you can’t really use that much RAM.
A reasonable use case is to have multiple smaller models loaded- you can have an image generation model loaded along with the text model. Or you can use this computer for development simultaneously with serving LLMs. Those ideas work okay. But trying to load up a single giant model is going to test your patience.