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Does creatine make you smarter?

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Re: Does creatine make you smarter?

#101
post #51

Earlier quoted context omitted.

I get severe muscle cramping, even after pounding water and electrolytes. Like I can’t handle my kid something in the car without risking a spasm.

spasms are commonly a potassium deficiency, you could take a multivitamin.

Multivitamins don't contain a lot of potassium because of the risk over overdosing in that form. Eat a banana instead (or 3).

Re: Does creatine make you smarter?

#102
post #11

Good discussion, but this conclusion: > I don’t know. Maybe a little. is not the right way to interpret the null result (insufficient evidence to reject null hypothesis that it has no effect) because the prior for supplements that people are trying to sell you is so low. In the absence of clear, strong evidence, you should assume the the whole thing is just an example of motivated reasoning. People want nootropics to…

I think this is quite different because (1) creatine has been proven to be completely harmless for people of all ages absent some rare thing like a kidney disorder and (2) it has a bunch of clearly measurable positive effects.

So this is more like trying to determine whether ginseng is good at keeping away colds or whatever. Maybe it does (actually quickly searching this, it definitely does but let's pretend it's as folksy as it sounds for a minute) but even if it doesn't then it's harmless and has a bunch of other effects, so when one takes it - the whole possible cold prophylaxis can just be seen as an added perk.

Re: Does creatine make you smarter?

#103
post #11

Good discussion, but this conclusion: > I don’t know. Maybe a little. is not the right way to interpret the null result (insufficient evidence to reject null hypothesis that it has no effect) because the prior for supplements that people are trying to sell you is so low. In the absence of clear, strong evidence, you should assume the the whole thing is just an example of motivated reasoning. People want nootropics to…

The null is surely different in this case because we know that supplemented creatine goes to the brain and the brain uses it, which is definitely not a claim all supplements can make.

The fact that there's a biologically plausible mechanism plus mixed statistical evidence makes "maybe" a perfectly reasonable conclusion.

Re: Does creatine make you smarter?

#104
post #90

I think another source of variation on the results is the actual nutritional intake of the subjects. The vegan/vegetarian is a big spectrum. A vegetarian eating plenty of dairy products and eggs should in theory be much better creatine-equipped than a poor vegan student feeding on noodles and ketchup pastas. A lot of pseudo-meat for vegans are full of processed shit. Confusion will be even higher if you include fish…

> if you include fish in the vegetarian diet, which is odd but some people do that.

Meat Is Murder but Fish Is Justifiable Homicide.

Re: Does creatine make you smarter?

#105
I have severe sleep apnea as well as insomnia. I may also be a multi-phasic sleeper. In any case my average sleep per night is ~3.5 hours with only ~1.5 hours of deep sleep. I use light therapy, CPAP, medications, etc but none of it solves my problems. I started taking creatine daily a couple of months ago. I've noticed a significant uptick in my cognitive abilities, despite being constantly sleep deprived. TFA doesn't touch on this apparent benefit of creatine, so thought I'd mention it for others who might be suffering from similar sleep issues.

Re: Does creatine make you smarter?

#106
I just ordered some yesterday because I saw something that reminded what my friend said recently about it boosting cognition. Then this morning I saw it mentioned in some health segment on tv. Now I stumble upon this discussion. Hmmm.

Re: Does creatine make you smarter?

#107
post #11

Good discussion, but this conclusion: > I don’t know. Maybe a little. is not the right way to interpret the null result (insufficient evidence to reject null hypothesis that it has no effect) because the prior for supplements that people are trying to sell you is so low. In the absence of clear, strong evidence, you should assume the the whole thing is just an example of motivated reasoning. People want nootropics to…

What I'm getting from all this is that we have an armchair expert explaining details about something they're not an expert in, and we have you reviewing the way they present this information, saying their very weak hedge wasn't strongly negative enough. Based on priors about the industry. Basically, HN doing HN things - having a good deep think about topics outside their realm of expertise, then debating the minutiae…

It may be minutiae, but olooney’s point is valid: the evidence doesn’t seem to support saying “maybe a little”. Remove that statement from the conclusion and it’s on the right track, aside from the arbitrary IQ point calculation which is nonsensical.

Re: Does creatine make you smarter?

#108
post #68

Most people taking creatine just need to drink water. They drink more water using creatine. In reality, the water/hydration is doing the heaviest lift, not the creatine.

This is not true. Did you read the article?

Yes. None of the supposed action of creatine was backed by any statistically significant study. Just drink water. Or don't. It's up to you.

Re: Does creatine make you smarter?

#109

Most people taking creatine just need to drink water. They drink more water using creatine. In reality, the water/hydration is doing the heaviest lift, not the creatine.

Plausible-sounding mechanisms like you're presenting here do not add value to the discourse without data. There are tons of plausible mechanisms we could make up absent empirical evidence to distinguish them.

Re: Does creatine make you smarter?

#110
> Wikipedia quotes a paper saying people make / recycle around 50 kilograms per day. That would imply that people make around 0.5787 grams per second. But this is in tension with the idea that people use 100 watts at rest. Since that 100 watt number seems to be more strongly established, I think 1 gram per second is a better estimate.

The cited paper in Wikipedia might be accurate and the author is just expecting "at rest" to mean awake but mostly idle. I'd wager that during sleep, we use less than 100W. For the sake of argument if you take out 8 hours (asleep time) from a 24 hour period, you end up with a rate of ~0.8681 grams per second, much closer to 1g/s. Anyway, just a little fun with numbers.

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