Earlier quoted context omitted.
You should check which part of your body has the most cholesterol.
How would I check the parts of my body for that?
I think they meant ask Google. It's the brain.
FDA approves new kind of cholesterol pill
51–60 of 74 posts
Re: FDA approves new kind of cholesterol pill
#52Earlier quoted context omitted.
I have heard this too, and that cholesterol measurements are flawed because they don't account for particle size. That you can actually have better 'numbers' but worse results, if you reduce particulate size but also overall volume. It's frustrating that the science behind cholesterol is constantly in wild flux, but at any discrete moment you're expected to accept whatever the momentary consensus is. Interestingly, m…
You might be missing out on any benefits from statins that are independent of the cholesterol reduction. It’s non-zero and debatably substantial.
What are the other benefits?
Re: FDA approves new kind of cholesterol pill
#53[dead]
Re: FDA approves new kind of cholesterol pill
#54What is the current state of understanding on high cholesterol as a leading or trailing indicator of poor health? I vaguely remember reading one theory that cholesterol was used by the body to mitigate arterial damage from other causes?
We've been testing for cholesterol for a long time now and have had other meds to lower it. It should be possible to see if lowering cholesterol via medication results in improved life expectancy or reducing cardiac events. I would think this study has been done a few times already. As someone who does not have much medical knowledge, I'm not even sure how to look this up or be able to assess what I see if I did.
Re: FDA approves new kind of cholesterol pill
#55One could eat healthy instead of course but hey, the good life .
eat healthy as in: only once a day and only six days a week. only water for drinking and only fresh stuff to eat, no meat, no eggs, nothing cooked, nothing baked, nothing fried, nothing grilled, nothing processed, no sugar and no salt.
Being a major shift from the good life one should start it with a 7 day water fast. (do I have to say "ask your doctor before embarking"? done)
Re: FDA approves new kind of cholesterol pill
#56One could eat healthy instead of course but hey, the good life .
eat healthy as in: only once a day and only six days a week. only water for drinking and only fresh stuff to eat, no meat, no eggs, nothing cooked, nothing baked, nothing fried, nothing grilled, nothing processed, no sugar and no salt. Being a major shift from the good life one should start it with a 7 day water fast. (do I have to say "ask your doctor before embarking"? done)
Yeah, when you grow up, get back to this comment to look how childish it is.
Re: FDA approves new kind of cholesterol pill
#57Earlier quoted context omitted.
For all people? No. For the vast majority of people? Yes. Eat healthy and exercise more.
The dietary impact on cholesterol in the blood is surprisingly low. Looking it up, this source says diet can affect 20-30% of your blood levels [1]. I don’t have a great statistic about exercise, but I’d encourage you to question what you think you know — at the very least I’ll claim you’re mistaken about the importance of dietary impacts on cholesterol, which perhaps should give you pause about your other beliefs [1…
I was responding to the glp-1 question.
And yes, exercising and dieting absolutely reduces the need for these medications.
It also reduces the amount of people who have high cholesterol, although again, in both cases not all
Re: FDA approves new kind of cholesterol pill
#58Earlier quoted context omitted.
Peter Attia had a great series of blog posts on this before his fall from grace: https://peterattiamd.com/the-straight-dope-on-cholesterol-pa... He also had a series of podcast interviews about this with Tom Dayspring. I believe his explanations are all mainstream, except he favors treating LDL and LP(a) more aggressively than normal doctors
Wait, why did he fall from grace?
1700 mentions of his name in the Epstein files that Trump released.
Re: FDA approves new kind of cholesterol pill
#59Not really a new kind of pharmaceutical, pcsk9 inhibitors have been on the market for a while now. What’s new is that it’s an oral medication rather than an injectable
But I vaguely remember them being expensive due to not being covered by insurance. Maybe this will change that?
Hmmm, maybe but I wouldn’t expect a sea change myself. The reason insurance is able to get away with not covering pcsk9 inhibitors is because statins in theory provide a similar benefit for a fraction of the price, and so they can gatekeep access by requiring patients to take statins first before providing prior authorization.
Now, structurally Repatha is straight up more expensive to manufacture and deliver to patients than a peptide like enlicitide, as the former is a biologic. And if a competitor decides to manufacture a biosimilar when Repatha comes off patent in 2030 that could also help cut the price of drugs in this category. But there’s really nothing cheaper than statins, so I would expect insurance agencies to continue to withhold prior authorization.
Re: FDA approves new kind of cholesterol pill
#60Earlier quoted context omitted.
You should check which part of your body has the most cholesterol.
How would I check the parts of my body for that?
The brain is the most cholesterol-rich organ in the body. While accounting for only 2% of body weight, it contains roughly 20% of the body's cholesterol. It is essential for nerve cell communication, learning, and memory.