FDA approves new kind of cholesterol pill

“Proprotein convertases (PPCs) are a family of proteins that activate other proteins. Many proteins are inactive when they are first synthesized, because they contain chains of amino acids that block their activity. Proprotein convertases remove those chains and activate the protein” [1].

[1] https://en.wikipedia.org/wiki/Proprotein_convertase

Not really a new kind of pharmaceutical, pcsk9 inhibitors have been on the market for a while now. What’s new is that it’s an oral medication rather than an injectable

What is the current state of understanding on high cholesterol as a leading or trailing indicator of poor health? I vaguely remember reading one theory that cholesterol was used by the body to mitigate arterial damage from other causes?

Yes, exciting stuff.

Not to mention the gene-therapy version of the same PCSK9 inhibition pathway called VERVE-102 which Eli Lilly is putting through human trials as we speak.

I imagine that stacking the LP(a) antisense therapy with a PCSK9 inhibitor, and/or a statin or Nexlizet would probably lower odds of heart disease death by two to three orders of magnitude. But I guess there isn't solid mortality data to say for sure.

you didn't read the article did you? Or are you actually here to claim that people with hypercholesterolemia just need to eat better?

Do you have the same simplistic ideas about GLP-1's?