Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

Vagal cholinergic denervation of the gastric mucosa in Long-COVID-19

ijidonline.com

Post reply on HN
Print view View original

51–60 of 89 posts

Re: Vagal cholinergic denervation of the gastric mucosa in Long-COVID-19

#51

Post by bruce511 »

jMyles wrote: post #15
flextheruler wrote: post #8

8 people as the entire control group... yeah I'd say "may" is the operative word in the title. My takeaway from long covid is that it's probably as severe as the much more deadly pandemic of the Spanish Flu. Considering there's now a newfound interest in "long flu", I think a spotlight has now been placed on the impact of severe respiratory illness. Whether that illness be covid or one of the any other respiratory il…

[flagged]

>> i think it's clear in retrospect that most of the interventions in the face of the pandemic were based on profit and scant science

Lock-downs weren't in the service of profit. The vast majority of businesses, big and small, were hurt (many fatally) by lock downs.

And yes, there was scant science involved. Almost all interventions were on a "best guess" basis. Govts around the world had to make very big decisions with no science at all. Anthropologists can dissect the data for decades to come. Govt response, but equally population responses will help guide future decision makers.

On the face of it, countries where lockdowns were adopted (by the population) typically had lower death rates, but that's somewhat anecdotal at this point.

Yes, vaccine development was hasty. Partly because very large studies were easy to setup. Yes some drug companies made profits. Yes unvaccinated people still died. Yes we dont know if the vaccines have generational level side effects.

All things considered I think we came out of it pretty well.

Re: Vagal cholinergic denervation of the gastric mucosa in Long-COVID-19

#52

Post by bonzini »

jMyles wrote: post #15
flextheruler wrote: post #8

8 people as the entire control group... yeah I'd say "may" is the operative word in the title. My takeaway from long covid is that it's probably as severe as the much more deadly pandemic of the Spanish Flu. Considering there's now a newfound interest in "long flu", I think a spotlight has now been placed on the impact of severe respiratory illness. Whether that illness be covid or one of the any other respiratory il…

[flagged]

I am not sure how lockdowns (millions of people not able to work) could be driven by profits.

Re: Vagal cholinergic denervation of the gastric mucosa in Long-COVID-19

#53

Post by synecdoche »

Erem wrote: post #45
jMyles wrote: post #15

Earlier quoted context omitted.

[flagged]

I’m here to disagree with what you said about lockdowns. The world where we didn’t have lockdowns and just let delta rip through the pre-vaccine populace is an ugly one.

Sweden had no lockdown and fared comparatively well.

Re: Vagal cholinergic denervation of the gastric mucosa in Long-COVID-19

#54

Post by synecdoche »

bruce511 wrote: post #51
jMyles wrote: post #15

Earlier quoted context omitted.

[flagged]

>> i think it's clear in retrospect that most of the interventions in the face of the pandemic were based on profit and scant science Lock-downs weren't in the service of profit. The vast majority of businesses, big and small, were hurt (many fatally) by lock downs. And yes, there was scant science involved. Almost all interventions were on a "best guess" basis. Govts around the world had to make very big decisions w…

For profit by those who it benefited, namely medical companies who made the so called vaccine.

Only by changing and relaxing the long standing criteria for what constitutes a vaccine.

Re: Vagal cholinergic denervation of the gastric mucosa in Long-COVID-19

#55

Post by Jedd »

synecdoche wrote: post #54
bruce511 wrote: post #51

Earlier quoted context omitted.

>> i think it's clear in retrospect that most of the interventions in the face of the pandemic were based on profit and scant science Lock-downs weren't in the service of profit. The vast majority of businesses, big and small, were hurt (many fatally) by lock downs. And yes, there was scant science involved. Almost all interventions were on a "best guess" basis. Govts around the world had to make very big decisions w…

For profit by those who it benefited, namely medical companies who made the so called vaccine. Only by changing and relaxing the long standing criteria for what constitutes a vaccine.

In what way are they not a vaccine?

Re: Vagal cholinergic denervation of the gastric mucosa in Long-COVID-19

#56

Post by tsoukase »

Firstly the term 'long' is not good. Better is post-COVID syndrom, because the virus has been eliminated and not staying for long but the situation remains post infection.

Secondly, the majority of burden is caused by CNS/brain dysfunction, especially a form of neurotransmitter depletion, and not due to peripheral autonomous imbalance. And the former is a much more difficult therapeutic target: in my experience incurable for ever but also quite more rare that it is shown in the media.

Re: Vagal cholinergic denervation of the gastric mucosa in Long-COVID-19

#57

Post by gregoryyy »

Jedd wrote: post #55
synecdoche wrote: post #54

Earlier quoted context omitted.

For profit by those who it benefited, namely medical companies who made the so called vaccine. Only by changing and relaxing the long standing criteria for what constitutes a vaccine.

In what way are they not a vaccine?

The definition of vaccine was broadened to include mRNA technologies.

Re: Vagal cholinergic denervation of the gastric mucosa in Long-COVID-19

#58

Post by danaris »

bruce511 wrote: post #51
jMyles wrote: post #15

Earlier quoted context omitted.

[flagged]

>> i think it's clear in retrospect that most of the interventions in the face of the pandemic were based on profit and scant science Lock-downs weren't in the service of profit. The vast majority of businesses, big and small, were hurt (many fatally) by lock downs. And yes, there was scant science involved. Almost all interventions were on a "best guess" basis. Govts around the world had to make very big decisions w…

It's not "no science at all".

Science understands how pandemics act in general quite well, and that informed the early responses.

Where you see the lack of scientific backing in the early responses is things like the recommendations to wash hands very thoroughly and use hand sanitizer constantly—this was from when it was thought that COVID might have spread through surface contact, before we understood that it was airborne.

(Of course, the other aspect that shows the lack of scientific backing, that is more about profit, is how even now, there's no real push to upgrade our institutional ventilation systems. That would've made a huge difference not just for COVID, but for many other pathogens, and even just pollution and allergens...but it would cost institutions with buildings worldwide a lot of money, so we can't have that...)

Re: Vagal cholinergic denervation of the gastric mucosa in Long-COVID-19

#59

Post by thenerdhead »

internet_user wrote: post #50
thenerdhead wrote: post #24

Earlier quoted context omitted.

they are pretty well understood now with growing evidence of viral persistence in the gut and immune cells, and immune dysfunction causing autoantibodies. they are also distinct from other conditions like ME/CFS or other sequelae although they may share overlapping symptoms. A lot of research is going into different PAIS post acute infection syndromes

Isnt CFS notoriously post-viral?

evidence says yes, but bacteria and other antigens are being studied. ME/CFS shows antigen persistence like long covid has clearly shown.

https://www.nature.com/articles/s41467-024-45107-3

Re: Vagal cholinergic denervation of the gastric mucosa in Long-COVID-19

#60

Post by thenerdhead »

remarkEon wrote: post #35
nradov wrote: post #18

Earlier quoted context omitted.

There's no such thing as "long COVID" specifically. Any serious viral infection has the potential to cause sequalae in susceptible patients for reasons that are still not well understood. Some of those are detectible in lab tests to an extent but there's no single clear diagnostic test.

Interesting, then I guess the obvious next question is … is there a test for being a susceptible patient? We’ve been talking about long COVID for years now. Surely there’s some commonalities amongst the people who suffer from it.

[dead]
Post reply on HN