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Vagal cholinergic denervation of the gastric mucosa in Long-COVID-19

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21–30 of 89 posts

Re: Vagal cholinergic denervation of the gastric mucosa in Long-COVID-19

#21
post #4

Wow mucosal innervation was around half in long covid patients - that's super worrying and would have nasty symptoms in practice. The findings also support the hypothesis that SARS-CoV-2 may cause structural nerve damage, which is perhaps the even bigger worry. :(

What kind of symptoms? I have insane stomach issues since early 2021 that only this year started to largely subside.

Re: Vagal cholinergic denervation of the gastric mucosa in Long-COVID-19

#23

Earlier quoted context omitted.

[flagged]

Problem with those conditions and long COVID and CFS are generally similar: No really reliable guaranteed test for most of them, just a series of symptomatic diagnoses and years of ruling out conditions. No offense, but while some people might be full of crap, you sound really insensitive.

If you suppose it's all malarkey and conjecture, what is the problem?

When your doctor says that you're wrong, do you accept his advice or tell him he should be more like Dale Carnegie?

Re: Vagal cholinergic denervation of the gastric mucosa in Long-COVID-19

#24
post #18

Is there a test for long covid?

There's no such thing as "long COVID" specifically. Any serious viral infection has the potential to cause sequalae in susceptible patients for reasons that are still not well understood. Some of those are detectible in lab tests to an extent but there's no single clear diagnostic test.

they are pretty well understood now with growing evidence of viral persistence in the gut and immune cells, and immune dysfunction causing autoantibodies.

they are also distinct from other conditions like ME/CFS or other sequelae although they may share overlapping symptoms. A lot of research is going into different PAIS post acute infection syndromes

Re: Vagal cholinergic denervation of the gastric mucosa in Long-COVID-19

#25

Is there a test for long covid?

Think of AIDS before the immune system dysfunction was found. That's where we are with Long Covid. One cause, a myriad of apparently unrelated effects--that's not how biology tends to work. Rather, there's something deeper we haven't found. And we certainly can't test for what we haven't found.

Re: Vagal cholinergic denervation of the gastric mucosa in Long-COVID-19

#26

Earlier quoted context omitted.

Problem with those conditions and long COVID and CFS are generally similar: No really reliable guaranteed test for most of them, just a series of symptomatic diagnoses and years of ruling out conditions. No offense, but while some people might be full of crap, you sound really insensitive.

If you suppose it's all malarkey and conjecture, what is the problem? When your doctor says that you're wrong, do you accept his advice or tell him he should be more like Dale Carnegie?

Most logical, rational adults would seek a second opinion, at least in places where those are available; they usually are. Interesting that I said 'some people' and you generalised.

FWIW, if my doctor were unfriendly enough, though, I might do that also.

Re: Vagal cholinergic denervation of the gastric mucosa in Long-COVID-19

#27

hopefully we will get somewhere with these studies. The lack of solid research on a disease that affects millions (likely a good percentage undiagnosed) is really tough for patients - and myself really, as I've found i likely suffer from this. Finding out about autonomic dysfunction and small fiber neuropathy as I researched my own fatigue and finding out I likely have this has been very challenging.

> as I researched my own fatigue and finding out I likely have this

Please don't do this. It's the medical equivalent of copy/pasting shit you don't understand from Stack Overflow.

Go see a doctor who has a degree and training.

Re: Vagal cholinergic denervation of the gastric mucosa in Long-COVID-19

#28

8 people as the entire control group... yeah I'd say "may" is the operative word in the title. My takeaway from long covid is that it's probably as severe as the much more deadly pandemic of the Spanish Flu. Considering there's now a newfound interest in "long flu", I think a spotlight has now been placed on the impact of severe respiratory illness. Whether that illness be covid or one of the any other respiratory il…

Yeah, twelve patients and eight in the control group isn't really a study.

is a small proof of concept study not a study anymore? gastric biopsies aren’t exactly easy to obtain at scale.

Re: Vagal cholinergic denervation of the gastric mucosa in Long-COVID-19

#29

Is there a test for long covid?

Think of AIDS before the immune system dysfunction was found. That's where we are with Long Covid. One cause, a myriad of apparently unrelated effects--that's not how biology tends to work. Rather, there's something deeper we haven't found. And we certainly can't test for what we haven't found.

This is nothing like AIDS.

Re: Vagal cholinergic denervation of the gastric mucosa in Long-COVID-19

#30

Earlier quoted context omitted.

Yeah, twelve patients and eight in the control group isn't really a study.

is a small proof of concept study not a study anymore? gastric biopsies aren’t exactly easy to obtain at scale.

They are studies, and frankly, without something like this, doing things like the appropriate power calculations and risk assessments for larger studies would be hard to do.
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