As early as the late 19th century, Louis Pasteur’s work had inspired a belief in the scientific community that it must, in principle be possible to selectively exterminate bacteria. The German physician Paul Ehrlich expounded on this in greatest detail in 1907 when he described his “magic bullet” (or Zauberkugel) theory for effectively targeting pathogens without harming the human host, similar to the immune system.
However, if you had had demanded someone for a blueprint in 1925 of how to design such a magic bullet, especially a magic bullet that targeted virtually all forms of bacteria, it would have sounded ludicrous. Yet, 20 years later, the world was manufacturing 6-7 trillion units of penicillin a year, capable of treating 3-6 million people. And that’s in spite of the fact that Fleming’s work sat mostly untouched for a decade before Howard Florey and Ernst Chain seriously set about to isolate and purify the substance.
You can quibble and say that penicillin was discovered, not designed, which is certainly true. But I would ask you to consider, does current AI development look more like design or discovery? Does it look more like analytical engineering or evolutionary selection? I would say on both counts the latter, in which case, we should prepare to be surprised how long it might take to make revolutionary advances. And that’s on both sides of the ledger, we might find ourselves stuck in the current paradigm for a long time. But, we might not be.