> Oxford Nanopore Technologies MinION ($7.5k) Hmm, I'll come back in a few years when things have become cheaper.
It's been around for a decade and was $1k in early access, so don't hold your breath.
How to sequence your own DNA at home
121–130 of 161 posts
Re: How to sequence your own DNA at home
#122If the sequencer was 10x cheaper then I might do it.
Re: How to sequence your own DNA at home
#123Earlier quoted context omitted.
Finding yourself in a genetically-determined out group, and being treated differently / discriminated against because of it.
Honestly, you don't need someone's genetics for this to happen. They will find out more about you by scraping your socials and spending habits and driving habits. I think this whole fear is over blown anyway. I am in a genetic out group (schizoaffective disorder and yes my risk is genetic) and the benefits of getting my genetics run twice out weighed any risk that might have befallen me.
[deleted]
Re: How to sequence your own DNA at home
#124Earlier quoted context omitted.
Finding yourself in a genetically-determined out group, and being treated differently / discriminated against because of it.
Honestly, you don't need someone's genetics for this to happen. They will find out more about you by scraping your socials and spending habits and driving habits. I think this whole fear is over blown anyway. I am in a genetic out group (schizoaffective disorder and yes my risk is genetic) and the benefits of getting my genetics run twice out weighed any risk that might have befallen me.
You have control over your habits, and what you reveal on your "socials". I post very little personal.
You have no control over your genes.
Re: How to sequence your own DNA at home
#125Earlier quoted context omitted.
Honestly, you don't need someone's genetics for this to happen. They will find out more about you by scraping your socials and spending habits and driving habits. I think this whole fear is over blown anyway. I am in a genetic out group (schizoaffective disorder and yes my risk is genetic) and the benefits of getting my genetics run twice out weighed any risk that might have befallen me.
You have control over your habits, and what you reveal on your "socials". I post very little personal. You have no control over your genes.
> You have control over your habits
If you have to change your habits because a secret system is watching over you it means they are already controlling you.
You cannot hide your bank account, where you drive, what you buy, and on and on and on.
And all I need to get your DNA is pick up a cup you drank from or go through your garbage.
Re: How to sequence your own DNA at home
#126I don't want to sequence at home. But I do want to sequence it using a third-party that gives me all the raw data. I live in Europe and I'm just a simple consumer. Does anyone know how I can do this? What service would I use / you can recommend? Them not keeping it on their side would be a huge bonus of course but not sure I can ask for that much.
YSEQ is basically a mom- and pop shop, two German scientists who helped set up Family Tree DNA's labs in Texas then went home to start a small competitor (I think there was some sort of disagreement or conflict) in the space of high-resolution Y DNA sequencing for genealogists. They also do high resolution full genome sequencing on request. But be warned, it takes a long time, and they reserve the right to cancel you…
> But be warned, it takes a long time
What's a "long time"? A month, a year, 10 years?
> They're not the cheapest option
Whats "not the cheapest"? 100 EUR, 1000 EUR, 10000 EUR, more?
Re: How to sequence your own DNA at home
#127Earlier quoted context omitted.
YSEQ is basically a mom- and pop shop, two German scientists who helped set up Family Tree DNA's labs in Texas then went home to start a small competitor (I think there was some sort of disagreement or conflict) in the space of high-resolution Y DNA sequencing for genealogists. They also do high resolution full genome sequencing on request. But be warned, it takes a long time, and they reserve the right to cancel you…
> But be warned, it takes a long time What's a "long time"? A month, a year, 10 years? > They're not the cheapest option Whats "not the cheapest"? 100 EUR, 1000 EUR, 10000 EUR, more?
From their website yseq.net:
- Whole genome sequencing ultra plus (150 Gbases raw data) is €699,- incl. shipping for the sampling kit
- "The turnaround time is approx. 5-7 months at the moment."
Re: How to sequence your own DNA at home
#128I don't want to sequence at home. But I do want to sequence it using a third-party that gives me all the raw data. I live in Europe and I'm just a simple consumer. Does anyone know how I can do this? What service would I use / you can recommend? Them not keeping it on their side would be a huge bonus of course but not sure I can ask for that much.
Many companies offer that. In the local area they have e. g. mail-like stations where you give out your order and they give you what you need (e. g. if it is a plasmid, it is mailed into storage boxes often on the same day or next day). "Not keeping it on their side" ... well. If they sequenced it, they have data in their computer, right? How could you avoid that? I don't see this as possible, it depends on trust (an…
Much like many cameras process and discard the RAW sensor data after processing to pixel data if not further compressing and discarding the processed pixel data to a lossy image format, even more so the raw BAM sequencing read data is vastly larger than processed VCF files. Even many companies that retain that data are liable to archive it offline rather than keep the raw reads permanently accessible online. There are real costs involved and a business case is needed for keeping that data. Especially with a decent privacy policy or regulations storing 100G or multiples of that online for free and downloading on demand is a significant compared to the entire cost of sequencing.
Re: How to sequence your own DNA at home
#129Earlier quoted context omitted.
Honestly, you don't need someone's genetics for this to happen. They will find out more about you by scraping your socials and spending habits and driving habits. I think this whole fear is over blown anyway. I am in a genetic out group (schizoaffective disorder and yes my risk is genetic) and the benefits of getting my genetics run twice out weighed any risk that might have befallen me.
You have control over your habits, and what you reveal on your "socials". I post very little personal. You have no control over your genes.
23andMe bet big that genetic big data would be super valuable. That really didn't work out for them.
It turns out that it's more valuable for advertisers to learn if you actually smoke, than that you have a genetic propensity for smoking. Your genotype is just useful for figuring out your phenotype, and in the vast majority of cases, your genetics (especially not at the resolution offered by 23andMe) are not a shortcut to learn your behavior, which is what they're really after.
You're probably already classed as some variety of paranoid/dissident for your careful social media preferences...
Re: How to sequence your own DNA at home
#130Earlier quoted context omitted.
I know you put an asterisk, but to make it clear: these locations are very far from random. They're the most informative positions, which is why we check them.
Well, they're what 23andMe thinks are most informative, for the things they think their customers care about. Or thought; for compatibility reasons they can't change their SNP panels very often or too much. And the interesting positions are still reasonably randomly distributed by nature :)
I don't do SNP design but I don't think 23andMe made their own chips at first (if they have ever). SNPs are chosen based on being informative for population discrimination, with traits being overlaid afterwards