To those suffering similar issues: don't give up. There are many off label options to pursue. Immuno-modulation is, from my observations, understudied. I won't list anything here though.
Also, we're continuously finding new roles that microbes play in autoimmune disorders, eg rheumatoid, a condition which I myself have managed to reverse from utterly disabling to perfectly functional. My rheumatoid was almost certainly triggered by microbial (bacterial/viral) activity.
H Pylori is ubiquitous, and quite transmissible. Medical journals describe the many ways it can transmit, even via flies landing on utensils, plates, etc. I do not suggest pylori is directly at work here, but the growing consensus when treating it is that reducing it, not eradicating it, may be the better approach. Considering the many ailments it might be contributing to, including some forms of cancer, protocols for managing it may be prudent. But pylori is one of many, and there are countless strains of it alone.
I got to the point where I would get rashes from touching certain materials. That persisted for over a year. Not presently though. Doctors literally mocked me though, and without the temptation of insurance to milk, would ave nothing to do with me, at times literally taunting me.
My last encounter with an ER doctor was due to nasal swelling and pain, accompanied by extreme fatigue and malaise. During the visit, he told me to simply use any sharp object to remove the internal swollen matter and consider taking antidepressants. As soon as he left the room, so did I, and promptly the hospital itself. Unconventional disorders can seem futile, but there are, until corporately aligned LLMs centralize information and substitute the internet altogether, many medical journals, case reports and research papers that remain available.
I had chronic high BP sitting often around 197/170. Doctors told me I'd need to remain on BP medicine indefinitely, and that it would almost certainly be irreversible. When I could no longer afford regular tests, my GP sent a certified letter dismissing me as a patient. That was the end of my BP meds. 4 years later, without any medication, my BP sits at ~128/87, which may not be ideal, but is better than it was while on the meds.
I will say, that if we can wangle a truly FOSS LLM, rigorously policed for corporate and institutional influence, a lot of what is presently ailing us could be resolved. Many answer are out there, many waiting to be conceptually synthesized, but there is a lot out there. And there is a lot of incentive going in both directions.