From what I've seen it's faced with a more stony resolve compared to side-effects of many USP substances.
Cannabis users face substantially higher risk of heart attack (2025)
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Re: Cannabis users face substantially higher risk of heart attack (2025)
#52What I find fascinating is how smokers rationalize their behaviour, e. g. "weed is harmless". When they compare it to fentanyl or heroine/cocaine, but compounds are never intrinsically harmless. But you can not get that message across most folks who are smoking weed. It's a somewhat similar issue, to some extent, when you look at sumo wrestlers. These have a significantly lower life expectancy on average than the res…
I mean let's face it, most of us reading this comment are medically obese and would probably live at least 2-3 years longer if we lost 20 pounds.
So why don't we?
Re: Cannabis users face substantially higher risk of heart attack (2025)
#53What I find fascinating is how smokers rationalize their behaviour, e. g. "weed is harmless". When they compare it to fentanyl or heroine/cocaine, but compounds are never intrinsically harmless. But you can not get that message across most folks who are smoking weed. It's a somewhat similar issue, to some extent, when you look at sumo wrestlers. These have a significantly lower life expectancy on average than the res…
Have you ever smoked/ingested cannabis before?
Re: Cannabis users face substantially higher risk of heart attack (2025)
#54people just want their recreational drugs it's as stupid as smoking/vaping and not even black box warnings will get people to stop now if you need pain management I can respect that 100% but you need to investigate Palmitoylethanolamide and Geraniol as alternatives * https://news.ycombinator.com/item?id=48700498
Can you respect folks who are treating mental/emotional pain or just physical?
The folks I know who attempt to 'treat' themselves with substances generally just get worse. That's not a judgement, just an observation.
Re: Cannabis users face substantially higher risk of heart attack (2025)
#55I wonder about all the confounding effects. In my country (famous for cannabis to be easy to come by (for decades already), and I saw many smoke from age 16 up as I grew up in 90's, 00's). I have always felt that the heavy cannabis smokers had something to compensate; stress, unrest, impending depression, friction with parents. It was never the healthy sporty types with fulfilling relationships, good grades or a nice…
> stress, unrest, impending depression, friction with parents Well, Id guess these are reasons for any case of substance missuse?
True.
Re: Cannabis users face substantially higher risk of heart attack (2025)
#56Just a few years ago cannabis was presented online as a miracle drug that could cure all physical and psychological diseases. Any criticism of the sacred cannabis was strictly forbidden and dissenters were burned alive in the figurative fire of social media. Interesting how times are changing.
Re: Cannabis users face substantially higher risk of heart attack (2025)
#57I wonder about all the confounding effects. In my country (famous for cannabis to be easy to come by (for decades already), and I saw many smoke from age 16 up as I grew up in 90's, 00's). I have always felt that the heavy cannabis smokers had something to compensate; stress, unrest, impending depression, friction with parents. It was never the healthy sporty types with fulfilling relationships, good grades or a nice…
I have largely stopped smoking because when I smoke regularly I end up weighing 20-30lbs more from eating everything.
Going on an actual calorie restricted diet while consuming cannabis is basically impossible for me.
Then instead of walking 60 minutes I end up sitting and listening to music.
There is really not anything for me that correlates with healthy behavior when I smoke.
Re: Cannabis users face substantially higher risk of heart attack (2025)
#58I wonder about all the confounding effects. In my country (famous for cannabis to be easy to come by (for decades already), and I saw many smoke from age 16 up as I grew up in 90's, 00's). I have always felt that the heavy cannabis smokers had something to compensate; stress, unrest, impending depression, friction with parents. It was never the healthy sporty types with fulfilling relationships, good grades or a nice…
In American collegiate and professional athletic circles almost everyone uses marijuana. I was a nationally ranked junior tennis player and even in that sport almost every other top junior I knew smoked weed.
Re: Cannabis users face substantially higher risk of heart attack (2025)
#59> researchers were unable to account for several potential confounding factors including the duration and amount of cannabis use or the use of tobacco or other drugs. Personally I'd wager a bet it's the tobacco and/or smoking that is the harmful part, but it kind of dumbfounds me they failed to account for "details" like "duration and amount of cannabis use", that feels like a very vital thing to control for. Nothing…
Edible forms of cannabis raise heart rate and blood pressure substantially as well.
I think this is making the assumption that temporally elevated HR and BP is bad.
Re: Cannabis users face substantially higher risk of heart attack (2025)
#60Earlier quoted context omitted.
This article refers to two studies. The retrospective study of 4.6 million people did account for tobacco use. > The findings are from a retrospective study of over 4.6 million people published in JACC Advances and a meta-analysis of 12 previously published studies being presented at the American College of Cardiology's Annual Scientific Session (ACC.25). > Kamel and his team conducted the retrospective study using d…
I know you can't judge a study by its abstract, but they don't even mention the dosing mechanism, it's just "cannabis use".
That's not really a fair standard by which to judge the study, abstract or not. The dosing mechanism information was not present in the underlying dataset available to them:
> This retrospective cohort study utilized the TriNetX health research network, which aggregates deidentified electronic medical records from health care organizations worldwide.
> 1) The cannabis-user group with cannabis use diagnoses (International Classification of Diseases, 10th Revision: F12.1, F12.9, F12.90).
You can't expect them to work miracles and come up with data they didn't have. They produced a valuable piece of research furthering our understanding of the cardiovascular risks of cannabis use based on a very large existing dataset that was available to them.
Of course they would love to be able to answer the question of whether smoking is worse for your heart than edibles and so on, and they stated they would like to do this in a future study. But that costs time and money to create an entirely new dataset, and you know what funding for science is like these days.
There's plenty of other evidence in the literature on the cardiovascular effects of THC if you want to see what our current understanding is there. TL;DR: smoking is worse than vaping or edibles; myocardial infarction risk spikes within the first few hours of using cannabis; but the risks are not limited to inhalation because THC itself has physiological effects that raise cardiovascular risk factors (increased heart rate, endothelial dysfunction, platelet activation raising clotting risk, inflammation and oxidative stress, etc.).