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Scientists reverse brain aging, with a nasal spray

stories.tamu.edu

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Re: Scientists reverse brain aging, with a nasal spray

#11

Post by SubiculumCode »

High impact journal for an interesting study that is admittedly largely out of my area of expertise. The limitation of it being done in animal models, is of course, noted, but also expected. The question I would ask is how well the underlying background research makes this outcome expected.

Re: Scientists reverse brain aging, with a nasal spray

#14

Post by SubiculumCode »

amingilani wrote: post #2

...in mice. > Therefore, this study examined the effects of late middle-aged (18-month-old) male and female C57BL6/J mice receiving two intranasal doses of hiPSC-NSC-EVs on neuroinflammaging in the hippocampus at 20.5 months of age. — https://isevjournals.onlinelibrary.wiley.com/doi/10.1002/jev...

The link to the actual paper was appreciated. The context of whether findings will generalize outside of mouse models can depend a lot on specifics of the problem.

Re: Scientists reverse brain aging, with a nasal spray

#15

Post by gavinray »

"Reverse brain aging", sure, in the same sense that taking Vitamin C reverses aging.

The nasal spray reduced markers of inflammation in hippocampal microglial cells.

A lot of things reduce inflammation. That is not "reversing ageing".

Of course, "reduces inflammation" doesn't headline very well...

Re: Scientists reverse brain aging, with a nasal spray

#19

Post by ghurtado »

antonvs wrote: post #7
doginasuit wrote: post #3

Earlier quoted context omitted.

To be fair though, I think we owe the mice a positive research outcome.

“Congratulations, you get improved brain function while we continue to run other experiments on you!”

You can now experience both physical pain and existential dread!
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