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For first time, a cell built from scratch grows and divides

quantamagazine.org

11–20 of 323 posts

Re: For first time, a cell built from scratch grows and divides

#11

> “It’s a big step forward to this holy grail of making a living thing out of dead components,” said Sijbren Otto, a systems chemist at the Stratingh Institute for Chemistry in the Netherlands who was not involved in the work. That is the holy grail? I get that the goal is to "grow" biofuels, plastic, fertilizer, drugs, or whatever else we can imagine. But is that worth the many apocalyptic sci-fi outcomes we can ima…

While this is an impressive step forward, there remains an extremely long way, probably of several decades, until being able to design and synthesize a cell comparable in complexity with a bacterium.

The thing that they made is more alive than a crystal, which when placed in a suitable solution will grow and reproduce its own structure, but much less alive than even the simplest known living cells.

Its "life" is similar to that of a brain-dead human, whose body is not left to die by a bunch of machines that pump air into its lungs and nutrients through its blood vessels.

The techniques developed to make this pseudo-cell might evolve eventually into techniques able to make a true cell and it is likely that valuable information can be extracted from experiments with it, but it is very unlikely that any of the ancestors of the living beings has ever had even a remote resemblance with this (because it is far too dependent on continuously receiving complex cellular components and nutrients from outside; simplified parasitic living beings could appear only when there already existed sufficiently complex living hosts for the parasites).

Some components of this thing are growing by reproducing themselves, but like I have said, so does any crystal, thus it is difficult to choose a criterion that will distinguish with certainty what is living from what is non-living.

The growth is followed by a kind of division into 2 vesicles, but that happens by a mechanism very different from any living cell. Many inorganic things will split when growing over a certain size, so again it is hard to decide whether this can be called living.

Re: For first time, a cell built from scratch grows and divides

#12

The aliens that seeded life on Earth are seeing us making baby steps. Expect a visit soon!

> aliens that seeded life on Earth are seeing us making baby steps

Or like a grad student didn’t dispose of their work properly and are desperately trying to distract from their scandal.

Re: For first time, a cell built from scratch grows and divides

#13
post #5

> “It’s a big step forward to this holy grail of making a living thing out of dead components,” said Sijbren Otto, a systems chemist at the Stratingh Institute for Chemistry in the Netherlands who was not involved in the work. That is the holy grail? I get that the goal is to "grow" biofuels, plastic, fertilizer, drugs, or whatever else we can imagine. But is that worth the many apocalyptic sci-fi outcomes we can ima…

I'm not a biologist so I can't say for sure, but it seems like it would be a lot easier to edit an existing living organism to produce those products than it would be to create completely from scratch. We already do this with the process known as precision fermentation. We've gotten very good at editing genomes via CRISPR and related techniques and are only getting better https://en.wikipedia.org/wiki/Precision_ferme…

It's desirable to have some kind of simple base to start from that is an easy-to-configure platform to deploy any kind of metabolic machinery.

Their "minimal" cell is not quite a minimum product because it depends on prebuilt ribosomes and can't reproduce on it's own. No danger of gray goo!

This is more like it

https://www.jcvi.org/research/first-minimal-synthetic-bacter...

but those guys could probably add components to their cell to make it truly self-supporting although in biology there is a big difference between "barely works" and "high performance"

Re: For first time, a cell built from scratch grows and divides

#14

> “It’s a big step forward to this holy grail of making a living thing out of dead components,” said Sijbren Otto, a systems chemist at the Stratingh Institute for Chemistry in the Netherlands who was not involved in the work. That is the holy grail? I get that the goal is to "grow" biofuels, plastic, fertilizer, drugs, or whatever else we can imagine. But is that worth the many apocalyptic sci-fi outcomes we can ima…

> That is the holy grail?

If you can disassemble and reassemble a thing, you can say you understand it. Not perfectly. But understand it. I’d imagine properly understanding rudimentary cellular biology will come with perks.

(Also, does the Holy Grail imply both a boon and a cost? Or is that just Indian Jones.)

Re: For first time, a cell built from scratch grows and divides

#15

> “It’s a big step forward to this holy grail of making a living thing out of dead components,” said Sijbren Otto, a systems chemist at the Stratingh Institute for Chemistry in the Netherlands who was not involved in the work. That is the holy grail? I get that the goal is to "grow" biofuels, plastic, fertilizer, drugs, or whatever else we can imagine. But is that worth the many apocalyptic sci-fi outcomes we can ima…

Have you not seen Jurassic Park?

Re: For first time, a cell built from scratch grows and divides

#16

> “It’s a big step forward to this holy grail of making a living thing out of dead components,” said Sijbren Otto, a systems chemist at the Stratingh Institute for Chemistry in the Netherlands who was not involved in the work. That is the holy grail? I get that the goal is to "grow" biofuels, plastic, fertilizer, drugs, or whatever else we can imagine. But is that worth the many apocalyptic sci-fi outcomes we can ima…

Man, I am so tired of the cynicism around here.

Anytime you do something interesting or useful someone accuses you of trying to build the apocalypse.

Re: For first time, a cell built from scratch grows and divides

#17
post #5

> “It’s a big step forward to this holy grail of making a living thing out of dead components,” said Sijbren Otto, a systems chemist at the Stratingh Institute for Chemistry in the Netherlands who was not involved in the work. That is the holy grail? I get that the goal is to "grow" biofuels, plastic, fertilizer, drugs, or whatever else we can imagine. But is that worth the many apocalyptic sci-fi outcomes we can ima…

I'm not a biologist so I can't say for sure, but it seems like it would be a lot easier to edit an existing living organism to produce those products than it would be to create completely from scratch. We already do this with the process known as precision fermentation. We've gotten very good at editing genomes via CRISPR and related techniques and are only getting better https://en.wikipedia.org/wiki/Precision_ferme…

It seems like this cell barely evolves, because the system they built for duplicating the DNA makes very few errors.

Natural life tends to evolve, which may have consequences for production.

For example, quorn production has to be restarted from a seed population after ~1000 hours because it tends to evolve colonial variants that break the product standards: https://www.davidmoore.org.uk/21st_century_guidebook_to_fung...

Re: For first time, a cell built from scratch grows and divides

#19

> “It’s a big step forward to this holy grail of making a living thing out of dead components,” said Sijbren Otto, a systems chemist at the Stratingh Institute for Chemistry in the Netherlands who was not involved in the work. That is the holy grail? I get that the goal is to "grow" biofuels, plastic, fertilizer, drugs, or whatever else we can imagine. But is that worth the many apocalyptic sci-fi outcomes we can ima…

While this is an impressive step forward, there remains an extremely long way, probably of several decades, until being able to design and synthesize a cell comparable in complexity with a bacterium. The thing that they made is more alive than a crystal, which when placed in a suitable solution will grow and reproduce its own structure, but much less alive than even the simplest known living cells. Its "life" is simi…

> Its "life" is similar to that of a brain-dead human, whose body is not left to die by a bunch of machines that pump air into its lungs and nutrients through its blood vessels

A brain-dead human is alive, but just facing systemic collapse, aka death. That's not to imply that what the scientists here have created is alive, but the comparison isn't so apt.

Re: For first time, a cell built from scratch grows and divides

#20

> “It’s a big step forward to this holy grail of making a living thing out of dead components,” said Sijbren Otto, a systems chemist at the Stratingh Institute for Chemistry in the Netherlands who was not involved in the work. That is the holy grail? I get that the goal is to "grow" biofuels, plastic, fertilizer, drugs, or whatever else we can imagine. But is that worth the many apocalyptic sci-fi outcomes we can ima…

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