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Frog-derived gut bacterium eradicates tumors in mice
151–160 of 207 posts
Re: Frog-derived gut bacterium eradicates tumors in mice
#152Earlier quoted context omitted.
> and have less ethical problems than experiments in humans More like, what's a mouse gonna do about it?
Wait patiently until their planet-sized computer gives them the answer they've been waiting for and then take their revenge
HaHa I was thinking just the same :-)
For those unfamiliar with the reference, in Hitchikers guide to the galaxy series, Mice are projections of hyper intelligent extra terrestrial beings from a higher dimension who commission the creation of planet earth complete with fossils as a giant organic computer
Re: Frog-derived gut bacterium eradicates tumors in mice
#153Earlier quoted context omitted.
Don't know about mice, but rats more or less have a 50% tumor/cancer chance if they really do get to live 1+ years. I think for some lines it goes up to 90%+.
Every rat (4 now) I've owned except one has died of cancer. Or at least, they died with cancer, I'm not a veterinarian. The one that didn't got the flu or something at 6 months and died of some respiratory issue.
Rats have such bad PR.
They make fun affectionate pets if you can stomach the idea that they will die on you.
Re: Frog-derived gut bacterium eradicates tumors in mice
#154Earlier quoted context omitted.
Spoken like someone who has never had to rebuild a generator or find out the hard way car wiring is mainly soy-based nowadays.
I owned a riding mower once. Mice built nests in the engine, blocking enough of the air cooling to result in overheating and blowing the main seal. After fixing that twice I got in the habit of removing enough of the shroudy bits to expose and remove the nests. That took as long as actually mowing the lawn. After a season of that I gave the mower away and now we pay a neighbor to cut the grass. We did consider trying…
Not sure where you are, but thanks to climate change, the Bay Area and parts of the UK are suffering a massive influx of rodents (breeding season is now 12 months). So, now I’m a bit of an expert.
You’ll find it’s less effort to mouseproof sheds than pretty much any other option.
Bucket traps with water are a good option. They auto-reset. They don’t maim and are no threat to cats/dogs like spring traps, do not kill predators and increase mouse populations like poison does. They’re more humane than glue, for sure.
We use a combination of those, spring traps (if we can put them in the path the mice take) and electrocution traps (in the house). We’ve killed 100’s of mice.
The other important thing to do is remove all piles of anything within 100 ft of all structures. Wetland/prairie is a good plan if you have a buffer zone.
Under no circumstances call Orkin. Complete waste of time. This comment contains more training than their technicians get, and they don’t do their jobs anyway.
Re: Frog-derived gut bacterium eradicates tumors in mice
#155Earlier quoted context omitted.
Regulators being paid off arent actually regulating things you know? Regulation as it is, is extremely flawed and prone to corruption.
Bad governance is a very hard problem to solve. We have been living in organized states for over 4000 years and various combinations of corruption and nepotism seem to be common problems regardless of the political and economic system. The very fact that the question "Quod custodiet ipsos custodes?" (who will guard the guards themselves?) was originally formulated in Latin is an indication of how long has this been g…
Isn't it "quis"?
It would be nice to get a classical education of course but I don't actually know the difference
Re: Frog-derived gut bacterium eradicates tumors in mice
#156Earlier quoted context omitted.
Spoken like someone who has never had to rebuild a generator or find out the hard way car wiring is mainly soy-based nowadays.
Wrapping your wiring harness in capsaicin tape works pretty well. Unfortunately, this is a discovery I made after multiple annoying and expensive repairs.
Chickens ate our environmentally friendly AC line insulator wrap. They won’t touch the cheap gray stuff, at least not after I wrapped it in foil tape.
(They can’t taste capsaicin, though now that I know that exists, I’ll pick some up for other projects!)
Re: Frog-derived gut bacterium eradicates tumors in mice
#157Earlier quoted context omitted.
There will, in fact, continue to be frogs. One theory of where posts like this come from: https://www.pnas.org/doi/10.1073/pnas.2527316123
If its all just people trying to be different, why is it always the same refrains in the same way?
Because “trying” to be different and actually being different are not the same thing
Re: Frog-derived gut bacterium eradicates tumors in mice
#158Previus discussion (from the university press release) https://news.ycombinator.com/item?id=46306894 (498 points | 6 months ago | 140 comments) I'll rehash my comment They used mice, because they are good for early tries. The researchers had 9 bacterias and only 1 was successful. Experiments in mice are cheaper and have less ethical problems than experiments in humans. (Hey! They even injected the cancer cells in mic…
Moneyshot:
> The three bacterial strains that successfully induced tumor regression (E. americana, C. portucalensis, and E. ludwigii) were all identified as facultative anaerobic bacteria.
> This finding is consistent with established principles of bacterial cancer therapy, as anaerobic bacteria possess the unique capability to selectively accumulate and colonize within solid tumors due to the characteristically hypoxic and immunosuppressive tumor microenvironment.
> This selective tumor colonization likely enabled efficient intratumoral bacterial proliferation and, in conjunction with activated immune cell responses, contributed significantly to the observed tumor regression phenomena.
Said in other words, the tumours created the ideal environment for anaerobic bacteria to multiply. Eventually causing a reaction from the body’s own immune response (which ignored the tumour but successfully detected the bacterial growth).
So one of the reasons this worked well was that the bacteria acted as a target for the immune cells, and they proliferated inside the tumour thus weakening it.
Re: Frog-derived gut bacterium eradicates tumors in mice
#159Earlier quoted context omitted.
Unregulated capitalism does not exist anywhere on this planet, and the US is in fact quite a bureaucratic country, though less so than many others. "putting power solely in the hands of the wealthiest." Do you think it is? Then let some of the wealthiest try to obtain a permit in downtown SF for a mere block of flats, the likes of which used to be built by the thousands 100 years ago. If it takes less than a decade,…
The wealthiest are having no problem acquiring permits for data centers. Why would they want flats when DCs are so much more profitable? Last century it was highways.
No problem? Didn't New York (the state) actually stop issuance of permits for data centers for a year or so?
Sure that you can get a permit somewhere, that is just federalism. But you may not get it where you want it, and given that data centers are now a part of the general culture war, I expect that many blue states will now attempt to regulate them out of existence, at least in urban and semi-urban areas.
Re: Frog-derived gut bacterium eradicates tumors in mice
#160Previus discussion (from the university press release) https://news.ycombinator.com/item?id=46306894 (498 points | 6 months ago | 140 comments) I'll rehash my comment They used mice, because they are good for early tries. The researchers had 9 bacterias and only 1 was successful. Experiments in mice are cheaper and have less ethical problems than experiments in humans. (Hey! They even injected the cancer cells in mic…
Cant it be just some immunity reaction induced by the bacteria what would not translate to humans?
It is an immunity reaction. The bacteria multiplied in the tumors until they triggered an immunity response, which caused the body to destroy the tumors along with the bacteria. Whether or not it translates to humans remains to be seen.