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What Ozempic does to the gut-brain axis

psychologytoday.com

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Re: What Ozempic does to the gut-brain axis

#331

Post by faangguyindia »

mattlondon wrote: post #329
faangguyindia wrote: post #249

Earlier quoted context omitted.

>But this intelectual knowledge doesn't really help if your body is telling you it's hungry all the time and it's hard not to eat something. Better choices can help, because different calories deliver different satiety; but some people don't get much satiety no matter what they eat. Maybe try to figure out why you’re feeling hungry. Is it because you’re running a 1000 kcal deficit? Can your body really tell whether y…

> Maybe try to figure out why you’re feeling hungry. Is it because you’re running a 1000 kcal deficit? For me I always feel hungry. Always ready to eat more. Always. It doesn't seem to matter what I eat or how much, I have no "off switch" apart from maybe being asleep. I sit at big family meals like Christmas or thanks giving and people around me are all "man I am going to pop if I have another bite" and yet I am sti…

If you've done all and sustainable dieting and workout has not done it for you, then i feel you maybe valid candidate for this drug. But i am refusing to believe average guy who is probably overweight by 22lb needs this drug.

Re: What Ozempic does to the gut-brain axis

#332

Post by faangguyindia »

toasterlovin wrote: post #327
faangguyindia wrote: post #321

Earlier quoted context omitted.

>For a lot of people, the reason they feel hungry is because the way their brain works is that they feel better when they feel full and their life sucks for some reason i am not trying to gain traction, i already know what i am saying applies to vast majority of people and i've yet to come across people who feel 200-300kcal deficit is impossible to apply for them because of their insane appetite. In most cases where…

You’re like a guy who’s confused why drug addicts don’t just try not taking drugs.

I've helped many people lose weight, become jacked, and go from underweight to a healthy weight.

I regularly hear from overweight and obese people who come to me, “I’m genetically predisposed to being fat.” Yet after a few months, we often make significant progress.

Many of them have also tried “deficit dieting,” and it didn’t work for them. But when I looked more deeply into their methods, I found they had calculated their maintenance calories incorrectly.

They were running huge, unsustainable deficits. They weren’t doing any Zone 2 cardio, which is an easy way to boost maintenance calories, and most of them were largely sedentary.

Many times, their diet consisted mostly of packaged, processed foods, and they weren’t eating enough protein or healthy fats or vegetables.

Simply fixing these issues led to major transformations. I’ve yet to come across someone who is truly resistant to these changes.

I do not doubt existence of people who simply cannot sustain even a small deficit or people who have no control over their diet but i've among 1000s of people i worked on i never found even 1 such person.

I keep an open mind maybe i'll eventually find such person, so far i've not.

Re: What Ozempic does to the gut-brain axis

#333

Post by tsimionescu »

faangguyindia wrote: post #325
tsimionescu wrote: post #310

Earlier quoted context omitted.

It answers the question, but you are simply wrong, as anyone who has tried to lose significant weight knows from personal experience, and as countless studies have confirmed again and again.

how many of those studies are designed to fail?

Badly designed? A lot of them, possibly. Designed to fail, intentionally? Few if any.

Re: What Ozempic does to the gut-brain axis

#334

Post by PotatoPrime »

faangguyindia wrote: post #255
klipklop wrote: post #238

Earlier quoted context omitted.

This comes off as extremely condescending. I am pretty sure the person you are trying to give basic dieting advice already knows this. Why are you trying so hard to convince people to not take medication that helps them?

when someone says something doesn't work, is it condescending to ask them what exactly they did?

If you're asking genuinely, yes it can be condescending to persist in asking for 'exactly' what they've done, especially when the discussion isn't focused on their diet or their success and failure.

People tend to not want advice when they're not seeking it, and when someone wants to dissect every detail of what they've done that hasn't worked, when they mentioned it merely as an anecdote, it tends to be perceived as condescending.

Re: What Ozempic does to the gut-brain axis

#335

Post by Netcob »

wpm wrote: post #21
joshuamcginnis wrote: post #16

Studies show almost all subjects regained the weight and reversed gains within 2 years. This means underlying issues (e.g., food addiction) aren't being addressed. Short of changing habits, the only maintenance solution is lifelong drug use and that doesn't sit well with me.

Why not? People take depression meds, blood pressure meds, all kinds of meds for their whole life. I'll be on omeprazole for reflux my whole life. It doesn't solve the underlying problem of my gut being prone to overpumping acid into my stomach. So omeprazole is problematic? The underlying issue is being treated, it's treated by taking the drug. It works. It's doing its job. I'd be curious as to how you came to this…

Because usually you can't study long-term effects before releasing a drug, and even then it can take a long time for them to surface.

I took antihistamines basically throughout my 20s. My allergy specialist said there's no reason not to. I developed some other issues and wanted to stop taking antihistamines to see if that would help (or get a hint whether they were causing it) - but that got me into itching hell for weeks.

In some online forums people reported the same and shared ways to get out of that "addiction" without going insane from itching.

My doctor didn't want to believe it and there was no research on it. That only appeared a few years later in the form of a paper called "Unbearable Pruritus After Withdrawal of (Levo)cetirizine" (2016). In the US, the FDA issued a warning in 2025, which is also the time when I heard about it. None of the doctors I went to back then reported this to anyone, so I'm surprised it got discovered at all.

As for my other issues I have no way of knowing whether they had anything to do with long-term antihistamine use. I'm a sample size of one, and none of the other stuff is quite as clear-cut as "unbearable itching".

I've had other issues with prescription drugs that didn't make the official list of side-effects and sometimes those side-effects don't just go away once I stop taking the drug.

That's why I'm very cautious when trying drugs I never had before, and even more so when it comes to taking them long-term.

Re: What Ozempic does to the gut-brain axis

#336

Post by tsimionescu »

faangguyindia wrote: post #253
genericresponse wrote: post #239

Earlier quoted context omitted.

Obesity is widely regarded as a chronic disease that includes the interaction of genetic and other factors with behavioral factors. The unbelievably low success rate of diet and exercise programs for long-term weight reduction is widely documented and quite consistent with the earlier poster's experience.

>The unbelievably low success rate of diet and exercise programs for long-term weight reduction is widely documented and quite consistent with the earlier poster's experience. where is your data from? what protocol did they follow?

Please suggest some studies that show high success rates in curing obesity long term (say, at least 5 years). If you seem to be so incredulous that this is a real problem, I assume you are basing this on some studies that did find it's doable, and we're just being ignorant.

Re: What Ozempic does to the gut-brain axis

#337

Post by tsimionescu »

faangguyindia wrote: post #258
spudlyo wrote: post #211

Earlier quoted context omitted.

One might think that weight loss is simply an energy balance issue. Sadly, it's far more complicated than that. You can burn 500-800 calories in an hour of cardio, and you can consume 500-800 calories of food in a few minutes.

If you are eating 2700kcal a day which is what an average male probably eats in West Why would you eat 2700+800 = 3500kcal? when you can do with 2700kcal?

Because you're feeling peckish. Because you hadn't had a good burger in a while. Because you saw a good looking pizza on TV and you can't order less than a full pizza. Because your mother made this good lasagna and would feel offended if you didn't eat a portion because you'd already eaten earlier. Because you're sadand tired and just don't want to also feel hungry, and eating a pack of oreos dipped in nutella is more pleasant than cooking a steak. Because you're feeling self-destructive and it feels good to ruin your diet and get that feeling of satiety that you've been denying for a while.

There are a million reasons like this. You need quite consistent motivation in order to not overeat; overeating is the default for most overweight and obese people.

Re: What Ozempic does to the gut-brain axis

#338

Post by habinero »

hamhock666 wrote: post #155
paulddraper wrote: post #149

Earlier quoted context omitted.

I mean…that’s just like depression medication. It’s possible to ignore sadness as well as hunger.

There are usually ways to fix the problems in your life, like sadness and hunger, without resorting to using drugs. Maybe not everyone but it is something we should strive for.

Why? There's zero prizes for unnecessary struggle. It doesn't make you a better person, it just means you struggled more.

Re: What Ozempic does to the gut-brain axis

#339

Post by Illotus »

Great drugs. Have dropped 10+kg couple of times and tried a few more with low carb. Dropped 20+kg with Ozempic and it boosted me to exercise. Its wonderful that even a string of bad nights don't push me to overeat: even if I eat more during the day it tapers of in the evening whereas before ut would just continue.

Re: What Ozempic does to the gut-brain axis

#340

Post by tsoukase »

From my real world experience of a few dozen patients, there is definitely a mood boost but only to those who lost weight. The effect may be due to the weight loss confidence and/or other mechanism. The cause seems difficulty to find.

My advice: in monopolar depression with increased weight especially due to binge eating take the SSRI Fluoxetine 20mg 1 up to 2 daily. It will make wonders.

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