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What Ozempic does to the gut-brain axis

psychologytoday.com

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Re: What Ozempic does to the gut-brain axis

#281

Post by cjbgkagh »

phil21 wrote: post #247
declan_roberts wrote: post #185

Earlier quoted context omitted.

GRAY market is way undercounted in peptide use. Go to the gym and there's like 25% of the people there taking gray market peptides (some for weight, some for injury repair, etc)

That would be black market, almost assuredly if you are talking about "injury repair" peptides. Exceedingly few prescribers in the US are writing for those. Grey market references stuff like HIMS where you are getting a real doctor to write you a prescription and a shady compounding pharmacy takes those Chinese black market peptides, compounds them, and ships them to your door. Black market is just going direct to th…

Gray market includes research peptides in that they are legal to sell for research purposes, not for the purpose of human consumption.

Re: What Ozempic does to the gut-brain axis

#282

Post by testbjjl »

ceejayoz wrote: post #152
faangguyindia wrote: post #139

Earlier quoted context omitted.

>my body and mind are no longer is in starvation mode What does it mean? If a drug reduces your desire to eat food, wouldn't it also decrease your desire to eat food beneficial for your body? I think the effect most people want is to stop craving junk food but still eat nutritious food required for muscle growth and health.

What if you could intentionally eat good food? I've heard it widely described as reducing mental noise around food.

Intentionally eating good food is a lot more about where your head is at than what you’re eating, like any other devices. You can better understand the mentality of a person by their diet that they evolved through personal experience.

Re: What Ozempic does to the gut-brain axis

#283

Post by jona-f »

The "gut-brain axis" is mostly bullshit invented to cope with the fact that doctors have sent patients to shrinks for decades with real sicknesses. Everybody knows you feel bad when your digestive is out of balance. It's the same english word for "I'm sick" and "I feel sick" since forever. No magical newly found "gut-brain axis" needed.

Eating junk food, especially sweetened food is a drug. You can do a withdrawal and get the reduction of food noise reported with semaglutide without getting dependent on another drug with so far unknown long-term effects.

Re: What Ozempic does to the gut-brain axis

#284

Post by perilunar »

tapoxi wrote: post #23
zhivota wrote: post #10

Tirzepatide at 1mg/week reduced my muscle soreness. I felt less depressed but this might just have been situational because I've been plagued by bad soreness after working out for years. Unfortunately after twelve weeks I had to stop because I felt a lot of nausea and tenderness in my upper abdomen, and was worried it might be pancreatitis developing. I'm not sure why it would happen at such a low dose but the sympto…

I got pancreatitis from Zepbound, but it was indirect. Turns out rapid weight loss can cause gallstones, especially if you're genetically predisposed to them. I had one that ended up stuck in the bile duct, causing acute pancreatitis. I had to get my gallbladder removed shortly after and hundreds of stones were found. I would consider getting an ultrasound since the stones don't just go away when you stop taking the…

Wouldn't that be cholecystitis (and a cholecystectomy), not pancreatitis?

Re: What Ozempic does to the gut-brain axis

#285

Post by kube-system »

Barrin92 wrote: post #223
crooked-v wrote: post #154

Earlier quoted context omitted.

For many people, the "underlying issue" is fundamentally just being too hungry for how they live. GLP-1s absolutely treat that.

> the "underlying issue" is fundamentally just being too hungry for how they live operative phrase in that sentence "how they live". They need to live more active lives. And that's better than a weight loss drug because inactivity causes systemic disease beyond weight gain. GLP-1 drugs do to hunger what pain meds do to pain, but if you're overweight and your back is aching because you're sedentary the solution isn't…

Unfortunately the reason many live sedentary lives is indirectly a result of broader societal conditions. The trend towards a more sedentary society is not a coincidental individual failing of millions of people. It is because our economies and our built environment contributed to it.

Re: What Ozempic does to the gut-brain axis

#286

Post by kube-system »

faangguyindia wrote: post #257
netheril96 wrote: post #248

Earlier quoted context omitted.

> They need to live more active lives. When I become more active, I also become more hungry due to the extra energy consumption. The net effect is little weight loss and more often than not weight gain. While being physically active is beneficial to health in many ways, it does little for losing or maintaining weight, at least for me.

deficit = tdee - intake Active life = higher TDEE which means you can eat more food while still maintaining same deficit.

Exercise also stimulates digestion and triggers a hunger response in many people. This is why exercise without diet often fails to result in weight loss.

Re: What Ozempic does to the gut-brain axis

#287

Post by kube-system »

faangguyindia wrote: post #139
dirtbagskier wrote: post #2

I'd take them even if they didn't make me lose weight - and I'm the type of person that doesn't like takeing Tylenol unless absolutely necessary. The best way I can describe it: my body and mind are no longer is in starvation mode. I plan, do, act and sleep well.

>my body and mind are no longer is in starvation mode What does it mean? If a drug reduces your desire to eat food, wouldn't it also decrease your desire to eat food beneficial for your body? I think the effect most people want is to stop craving junk food but still eat nutritious food required for muscle growth and health.

It does which is why medically supervised weight loss with GLP1s includes diet recommendations to mitigate this.

But in my experience, decreased cravings make it easier to choose food rationally. The food noise that causes people to overeat usually doesn’t cause them to overeat healthy foods anyway.

Re: What Ozempic does to the gut-brain axis

#288

Post by ssl-3 »

hack1312 wrote: post #268
ssl-3 wrote: post #240

Earlier quoted context omitted.

Is the drug at risk of being discontinued? If so, then can that risk be quantified in any way? (For comparison: Countless scores of diets are discontinued daily.)

If the person can’t afford the drug then it’s at risk of being discontinued.

That's certainly a risk for a subset of people with limited incomes.

Meanwhile: Diets have been discontinued by people of all income levels for as long as we've had diets to discontinue. Some people succeed with their diets, and some don't.

Re: What Ozempic does to the gut-brain axis

#289

Post by s5300 »

cjbgkagh wrote: post #157
emmelaich wrote: post #146

Earlier quoted context omitted.

Interesting! Is it possible that you're just eating less of whatever triggers the autoimmune symptoms?

No, if that’s all it was then ME/CFS would be a cake walk and it isn’t. I have such a crazy restrictive diet and have had for a long time that one of my issues was being kicked out of doctor's offices for looking too healthy. The diet is necessary but not sufficient.

[dead]

Re: What Ozempic does to the gut-brain axis

#290

Post by solumunus »

faangguyindia wrote: post #139
dirtbagskier wrote: post #2

I'd take them even if they didn't make me lose weight - and I'm the type of person that doesn't like takeing Tylenol unless absolutely necessary. The best way I can describe it: my body and mind are no longer is in starvation mode. I plan, do, act and sleep well.

>my body and mind are no longer is in starvation mode What does it mean? If a drug reduces your desire to eat food, wouldn't it also decrease your desire to eat food beneficial for your body? I think the effect most people want is to stop craving junk food but still eat nutritious food required for muscle growth and health.

Specifically for me it makes junk food unpleasant. My diet is now impeccable. I hardly ever have a takeaway and if I do it needs to be something that is not greasy and is good clean food.

I also find drinking alcohol much less pleasant. I still drink sometimes but after a few beers or glasses of wine it starts to become very unappealing and I stop.

I do bodybuilding and I’m still getting my 150g of protein in.

I’m barely overweight and I’m losing weight very slowly but I’ve decided I’m likely to stay on GLP’s long term, if not forever, just because the lifestyle changes have been so incredibly good.

Perhaps this helps dispel the myth that GLP drugs inherently = relentless starvation.

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