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What Ozempic does to the gut-brain axis

psychologytoday.com

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Re: What Ozempic does to the gut-brain axis

#111

Post by hackingonempty »

Aaargh20318 wrote: post #82
saberience wrote: post #69

Earlier quoted context omitted.

[flagged]

The problem with exercise is that our bodies are quite efficient with their energy usage. A few minutes of ‘calories in’ takes many hours of ‘calories out’ to burn. You can’t really exercise enough to offset the food you can eat in a day, even if you somehow were able to dedicate all your time to exercising you would still have to limit your food intake. Add to that the fact that exercise is mind numbingly boring and…

> You can’t really exercise enough to offset the food you can eat in a day, even if you somehow were able to dedicate all your time to exercising you would still have to limit your food intake.

People racing the Tour Divide, a 2700 mile solo unsupported bikepacking race through the Rocky Mountains, lose weight when riding their bikes 18 hours a day for 2-3+ weeks straight. They describe being unable to choke down enough food even though what they are eating is very calorie dense. Hotdogs, burritos, burgers, pizza, a pound of gummies every day, chocolate milk and ice cream when resupplying, McDonalds where they fill their hydration bladders with PowerAde, anything they can get their hands on quickly when they arrive at a small mountain town which frequently has nothing more than a gas station.

https://www.facebook.com/groups/tourdivide/posts/24754803527...

Obviously not a practical solution as you say but they do exercise enough to offset the food when eating as much as they can.

Re: What Ozempic does to the gut-brain axis

#112

Post by SubiculumCode »

nihonde wrote: post #77
SubiculumCode wrote: post #65

Earlier quoted context omitted.

And this morning, I cut another hole in my belt. Turns out, losing weight and being thin was never about willpower or laziness in the face of absolute food abundance. It was mostly about whether a person was born lucky enough to have a moderate appetite, or was born burdened by exaggerated appetite. The underlying issue is physiological food cravings, not some personal failing or lack of willpower, and GLP-1 absolute…

The idea that appetites are assigned at birth is a bold claim. Is there evidence to support it?

Genetics and epigenetic factors.

Re: What Ozempic does to the gut-brain axis

#113

Post by JumpCrisscross »

9x39 wrote: post #103
JumpCrisscross wrote: post #99

Earlier quoted context omitted.

> dislike the personal responsibility angle I dislike the rejection of evidence. These drugs solve a problem. Preaching personal responsibility does not. In that way it almost reminds me of drug prohibition and abstinence-only rhetoric.

The evidence of where their fat stores came from?

> evidence of where their fat stores came from?

Yes. Specifically, how basal metabolism is not a consciously-controlled rate that modifies itself against diet and exercise to the point that in some people with serious metabolic syndrome it may be impossible for them to lose weight through diet and exercise without suffering nutritional shortfalls.

Also, the clinical evidence around what works for people losing weight and getting healthier and what doesn’t. Like, I get we have a powerful fast-food and sugary-drinks lobby in America, but wow is it wild seeing people get uppity about third parties’ private healthcare decisions like this.

Re: What Ozempic does to the gut-brain axis

#114

Post by rubicon33 »

tsol wrote: post #107
rubicon33 wrote: post #8

Earlier quoted context omitted.

Do you honestly believe in the so called “free lunch”? I mean there are MANY substances you can presently take that make you feel way better, but always come with a cost or a downside. Why should we believe GLP-1 class drugs are any different?

Antibiotics are pretty much a free lunch but they exist. Completely stops deadly disease without causing any long term damage. They exist it's just rare

Interesting point… and I suppose for the most part, I agree. A rare case of a mostly free lunch.

Re: What Ozempic does to the gut-brain axis

#115

Post by buck746 »

crooked-v wrote: post #17

I'm curious if this post will also have the same phenomena I've seen before of people springing out of the woodwork to post moralizing comments about people shouldn't rely on drugs, about how actually GLP-1s are bad because they don't fix problems indefinitely with a single dose, about how people should fix their problems by just having more willpower, talking about 'but what about the unknown side effects?' of drugs…

Semaglutide has been used for diabetics for roughly 20 years. The FUD angle is just people rambling against something that doesn't affect them personally. Everyone knows the only things that matter are what effects "you", everything else is just fantasy. If we could rid ourselves of that mindset we could build a much better world.

Re: What Ozempic does to the gut-brain axis

#116

Post by cflewis »

applfanboysbgon wrote: post #90
ceejayoz wrote: post #86

Earlier quoted context omitted.

> That's why they could stop being fat, if only they chose to. This seems like one of those "replication crisis" claims. > That's why they could stop being fat, if only they chose to. So they're pre-ordained not to? I have a loved one who certainly chooses to, to the point of having had bariatric surgery; GLPs have been an important follow-up. It's really not as simple as you make it out to be. > You don't go from 12…

> So they're pre-ordained not to? No. I'm saying it's within their power, so they aren't pre-ordained either way. You were suggesting that it's impossible for a large percentage of the population to not be obese without medical intervention, that it was comparable to excessive acid production which is a genetic anomaly and out of an individual's own control. > What if that cultural one is letting the processed foods…

Yeah, you see, this is the same thinking that leads you to say "People who are depressed should just think happier thoughts."

Re: What Ozempic does to the gut-brain axis

#117

Post by SubiculumCode »

Aaargh20318 wrote: post #75
9x39 wrote: post #55

Earlier quoted context omitted.

If they were a normal weight they would not have been prescribed the drug. The underlying issue is they're overweight because they eat too much. Anything more is speculation. There is usually no free lunch when it comes to pharma, and extrapolating long term or lifetime dependence as being equivalent to short term interventions is an unsupported leap.

That’s the problem with these new weight loss drugs. Ultimately they work by reducing food intake. For many people food is one of the few things in life that gives them some form of joy. I won’t ever take any drug that will take that away from me. Life is depressing enough as is. What we need is a weight loss drug that lets you eat unlimited amounts of food, preferably even suppressing the feeling of fullness, withou…

Have you taken this drug? Because they don't reduce my enjoyment of food. Quite the opposite; I enjoy it more...its just that I get full feeling much quicker, and am less likely to go graze in the kitchen. But enjoy? No, I enjoy my food quite a bit.

Re: What Ozempic does to the gut-brain axis

#118

Post by SubiculumCode »

cflewis wrote: post #110
JumpCrisscross wrote: post #98

Earlier quoted context omitted.

> that will take that away from me They don’t stop eating, just overeating. Getting joy from food is different from self medicating with overconsumption. (For the record, I love food. I also don’t have an issue maintaining a healthy weight and physique.)

This is it. I am on GLP-1 (Zepbound). I have done Weight Watchers multiple times. I'd lose the weight for a little bit, then it would come back. The reason was _I was hungry all the time_. It's not sustainable. As someone else in WW told me: "The easy bit is losing the weight. The hard part is continuing to eat that way your whole life." It's simply a faulty hunger sensor in my body. It was not what I was eating, sim…

So many misconceptions in these threads; your take is spot on and accurate.

Re: What Ozempic does to the gut-brain axis

#119

Post by cflewis »

dyauspitr wrote: post #47

What’s the downside to this magical drug. There has to be a downside…

Nothing in this world is free, GLP-1s have their downsides (excluding cost).

Mostly it's nausea and gastrointestinal distress side effects. These tend to cool down over time, but it'll put a ceiling on how big a dose you can tolerate. Some people can't tolerate a dose at any level.

Re: What Ozempic does to the gut-brain axis

#120

Post by phil21 »

Aaargh20318 wrote: post #75
9x39 wrote: post #55

Earlier quoted context omitted.

If they were a normal weight they would not have been prescribed the drug. The underlying issue is they're overweight because they eat too much. Anything more is speculation. There is usually no free lunch when it comes to pharma, and extrapolating long term or lifetime dependence as being equivalent to short term interventions is an unsupported leap.

That’s the problem with these new weight loss drugs. Ultimately they work by reducing food intake. For many people food is one of the few things in life that gives them some form of joy. I won’t ever take any drug that will take that away from me. Life is depressing enough as is. What we need is a weight loss drug that lets you eat unlimited amounts of food, preferably even suppressing the feeling of fullness, withou…

I dunno. It’s not universal, but I have a newfound joy when it comes to food after being on a GLP-1 and losing about 100lbs.

Sure, I don’t get the instant giant dopamine spikes from binge eating $30 worth of Taco Bell or a couple large pizzas. Once in a while I do miss that, but I can still do it now that I’m a few years into the weight staying off. It’s just not worth how shit I feel the next couple days afterward.

But healthy Whole Foods? What was once kind of meh for me is now something I look forward to and explore. Both going out to foodie type spots, and cooking at home. Both gourmet and basic. Just tasting the nuances and everything in some well prepared veggies or whatnot is great and not something I used to appreciate.

I also don’t constantly feel like crap with stomach issues either. I suppose there is less “addictive” type vice enjoyment in my life in some way, but the tradeoff has been life changing. I certainly still get plenty of joy from many of my meals when I feel the need!

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