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FDA advisors unanimously vote to approve Moderna's mRNA after agency drama

arstechnica.com

121–130 of 173 posts

Re: FDA advisors unanimously vote to approve Moderna's mRNA after agency drama

#121
post #85

Earlier quoted context omitted.

Or perhaps he never did give a fuck?

We take comfort in fantasizing about a black and white world and condemn others without trying to understand what drove them to act this way. If, perhaps, we could understand the underlying causes we could remove them and prevent as much evil from arising in the future. But we first have to admit that cause and effect is real and applies to human behavior.

Dude just stop.

Re: FDA advisors unanimously vote to approve Moderna's mRNA after agency drama

#122
post #110

Earlier quoted context omitted.

Vaccine skepticism is on the same level as flat earthism. This is not an insult to your person, but this is the reality of the science. Trading a 0.1 micromort risk once for a 1000 micromort risk over your lifetime is a crazy good deal. Put another way: that's trading ~6 minutes for ~24 days of life. You do that for every vaccine. Some vaccines have worse trades depending on your situation, and some are far better tr…

>Trading a 0.1 micromort risk once for a 1000 micromort risk I think like with that person that found their cancer to have some dna from an mrna vaccine in it the issue is when the prominent messaging is that there is no 0.1 micromort risk. There is no risk whatsoever and everyone who says so is a looney. Immediately you'll have thousands who say i told you so and harden their conviction.

> There is no risk whatsoever and everyone who says so is a looney.

No. Lying about the risks is what got us in this mess. There IS a risk. It's just crazy low. https://boxed.github.io/micromort/?q=vaccine&scale=log These are the real risks. Yellow Fever vaccine is the worst with ~7 micromort risk. That's roughly your baseline risk just by living for 7 hours. It's not a lot, but saying it's zero is false, and lying about shit is how you radicalize people.

Re: FDA advisors unanimously vote to approve Moderna's mRNA after agency drama

#123

Earlier quoted context omitted.

>Trading a 0.1 micromort risk once for a 1000 micromort risk I think like with that person that found their cancer to have some dna from an mrna vaccine in it the issue is when the prominent messaging is that there is no 0.1 micromort risk. There is no risk whatsoever and everyone who says so is a looney. Immediately you'll have thousands who say i told you so and harden their conviction.

The COVID19 vaccines were the most-discussed vaccines ever. And there was an enormous amount of coverage for the potential side effects. Recommendations were adjusted based on new data. There was also bad communication on the topic, often when politicians got involved or due to outdated information continued to be repeated. But there certainly was a lot of public discussion about the risks of the vaccines, they were…

It didn't help that the AstraZeneca vaccine was fairly bad all things considered. At roughly 3 micromort according to the latest data it's quite a lot of risk for a modern vaccine actually. Now, compared to getting Covid it's still better. Even for a 10 year old the covid risk is ~20 micromort and we don't recommend vaccines for that group. Which seems a bit bonkers when you consider that trading 20 for 3 is clearly a good choice, it's just that anti-vaccine loonies make politicians scared out of their minds, so they will rather have lots of kids dying than a few kids dying from vaccines.

Re: FDA advisors unanimously vote to approve Moderna's mRNA after agency drama

#124
post #30

Earlier quoted context omitted.

That is a good question, and I'm sure many of the people at UCSF are asking similar questions. However, his sort of misconduct is not the type that would usually violate tenure protections. Beyond the minor CV fibbing, without some evidence that he actually, say, solicited a bribe from Moderna, it's unlikely that he can face any sort of official sanction. The fraud is in his supposed thrust towards better scientific…

> he is so sloppy with major decisions of life and death To be clear, the FDA regulates marketing claims. “Is the label accurate?” Major decisions about life and death are between the doctor and the patient, not the FDA. It sounds like you’re taking an expansive view of this government agency’s mandate. People will push back on this at the ballot box, even if they can’t put it to words themselves.

[deleted]

Re: FDA advisors unanimously vote to approve Moderna's mRNA after agency drama

#125
post #85

Earlier quoted context omitted.

Or perhaps he never did give a fuck?

We take comfort in fantasizing about a black and white world and condemn others without trying to understand what drove them to act this way. If, perhaps, we could understand the underlying causes we could remove them and prevent as much evil from arising in the future. But we first have to admit that cause and effect is real and applies to human behavior.

Cause? We don't care. Effect? We all are sicker and closer to the grave because these ghouls are preying on us. We don't care about the justifications for murdering the collective for personal gain, its just treason to humanity plain and simple.

Re: FDA advisors unanimously vote to approve Moderna's mRNA after agency drama

#126
post #66

Earlier quoted context omitted.

> I would not say shutting down all discussion about a topic (lab origin) that ends up getting vindicated is a minor scandal. “Shutting down all discussion” - lol. I mean this is grossly hyperbolic. Were social media companies coordinating with the government to slow disinformation? Yes. Was it applied too broadly? Maybe. But describing it as “shutting down all discussion” is a disservice to people who don’t know as…

Harris lost by a couple percentage points in few key states. Perhaps the news you are talking about wouldn't be happening if trust in institutions hadn't fallen so low. I don't think whataboutism is helpful here. I think the FDA was broadly well-intentioned, and this administration is not. But this article isn't about ICE.

You're right, this article is about the Trump administration going out of their way to pick political appointees who go out of their way to make us sicker in such a despicable way that even they cannot justify it.

It's wild to me that we keep talking about Biden/Kamala as if they are the ones responsible for the lost in trust in institutions when we have a Republican party and Fox news that blast that the government can do nothing right for the last 3 decades of my life.

Sure, the Democrats can do a LOT better for the common folk, but it's so misplacing the blame as to be mind boggling.

Re: FDA advisors unanimously vote to approve Moderna's mRNA after agency drama

#127

Earlier quoted context omitted.

Having lived through it myself, I found the government’s actions extremely mild when compared to something like what ICE has been up to. Zero people were directly killed by authorities because of Covid noncompliance. From my perspective, it’s hysteria borne out of the difference in requirements for urban health policy vs. rural health policy, and the fact that rural people quite often travel through urban areas (e.g.…

I was more middle of the road. I live in a rural red red state. Then during COVID people would yell at my dying of cancer mother on chemo for wearing a mask while grocery shopping. Eventually the stores had to set special hours so people like her could shop without harassment. My politics have been greatly impacted. I was shown there is no compassionate conservative, that is just cover for 'fuck everyone who is not m…

I am so sorry that happened to you and your mom. We've become so tribal there's very little space for compassion for the vulnerable as we are positioned to fight tooth and nail.

Re: FDA advisors unanimously vote to approve Moderna's mRNA after agency drama

#128

The subversion of scientific expertise to replace it with podcasters and political sycophants is one of the biggest disasters of the current years. The very concept of merit has been destroyed and replaced with judgement calls on celebrity (necessary for leadership role) and subservience to the political whims of the last 15 minutes (and you had better switch in the next 15 minutes or you're out).

Really reminds me of the Russia leadership portrayals in Chernobyl.

It's basically Lysenkoism

Re: FDA advisors unanimously vote to approve Moderna's mRNA after agency drama

#129

Earlier quoted context omitted.

How is discussion on HN different from the leadership levels at FDA? Very different. Decisions with enormous health implications, enormous financial implications, are made at FDA. At HN, most people are here to learn, here to understand more. Vinay Prasad is a fraud, completely unfit for the leadership role he was placed into, making baffling and arbitrary decisions on his own, overturning those with far more experie…

At HN, most people are here to learn, here to understand more. There's a substantial "learn and understand" cohort, but there are other factions. At the start of the pandemic, there were 2 posters explicitly here to proselytize Trump style conservatism. I'm reasonably certain there was an anti-vaxx voting ring 2020-22, and I suspect there's remnant Elon fanboy and MAGA coordinated voting. I'd love to be proved wrong…

Oh they are still here, last time I had a good chuckle was the group arguing that The Pope Is A Democrat. "You know your brain is pickled when..."

Re: FDA advisors unanimously vote to approve Moderna's mRNA after agency drama

#130
post #123

Earlier quoted context omitted.

The COVID19 vaccines were the most-discussed vaccines ever. And there was an enormous amount of coverage for the potential side effects. Recommendations were adjusted based on new data. There was also bad communication on the topic, often when politicians got involved or due to outdated information continued to be repeated. But there certainly was a lot of public discussion about the risks of the vaccines, they were…

It didn't help that the AstraZeneca vaccine was fairly bad all things considered. At roughly 3 micromort according to the latest data it's quite a lot of risk for a modern vaccine actually. Now, compared to getting Covid it's still better. Even for a 10 year old the covid risk is ~20 micromort and we don't recommend vaccines for that group. Which seems a bit bonkers when you consider that trading 20 for 3 is clearly…

I suspect the issue is in part also just selfishness.

That 20 is in large part the kid that was brought into the hospital too late if at all. The kid that might have had astma or what have you.

The 3 is potentially yours or one in your family or friend group or community. It is a government mandated death and you might already distrust the gov.

A tragic event vs an authoritarian death inflicted upon you from that perspective.

My grandma is a scientist presumably very familiar with all this stuff but when her partner (not my grandpa) died from a bloodcloth shortly after getting an vaccine she also veered into that territory.

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