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The ability to regrow body parts is dormant in mammals, not lost

sciencedaily.com

11–20 of 75 posts

Re: The ability to regrow body parts is dormant in mammals, not lost

#11
Retina is a good example of this. Zebrafish can regrow damaged retina, but while mammals have the same stem cells (Muller glia), they dont repair the retina, but form scar tissue. There is a lot of research and I think they have managed to modify rat genome, so that their retina has showns some repair abilities. The problem is that it often causes tumors.

I have other retina permanently damaged, and suffer from double vision when looking small objects like text.

Re: The ability to regrow body parts is dormant in mammals, not lost

#13
post #9

Earlier quoted context omitted.

2 years I ago I sliced maybe 1.5mm frommy thumb-tip; when taking off the bandage, I could clearly see the "straight cut" and that some material was missing. Until today, it recovered completely

Lol, I once sharpened my knives and went to cook. During the prep I said, "wow I wonder how sharp the knife is", next thing you know, i cut about 1/4" of my finger tip off, right through the finger nail with zero resistance. Besides the blood getting everywhere and needing superglue to stop it, it grew back completely fine.

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Re: The ability to regrow body parts is dormant in mammals, not lost

#14
post #11

Retina is a good example of this. Zebrafish can regrow damaged retina, but while mammals have the same stem cells (Muller glia), they dont repair the retina, but form scar tissue. There is a lot of research and I think they have managed to modify rat genome, so that their retina has showns some repair abilities. The problem is that it often causes tumors. I have other retina permanently damaged, and suffer from doubl…

Ah, I was wondering the evolutionary reason why those genes would have gone dormant.

Cancer is a sensible answer.

Re: The ability to regrow body parts is dormant in mammals, not lost

#15

Wasn't this proven many years ago by a random guy who used a "extra-cellular matrix" of stem cells to regrow his severed finger, nail and all? Found it: http://news.bbc.co.uk/2/hi/7354458.stm

No, the end of your finger just can grow back. https://www.npr.org/sections/health-shots/2013/06/10/1903854... Dude's brother had him throw his product on the finger as it did so, definitely an astute marketing trick. https://www.theguardian.com/science/2008/may/01/finger.claim

"I don't know how it works, so it must be fake news."

To be fair, the person being skeptical is just a surgeon, this is not a peer-reviewed study or anything actually scientific.

Your NPR link even shows that scientists realize there are still unknowns:

> "We think that nail stem cells may a have a special function to induce the whole regeneration process, including nerve attraction and growth of the bone," Ito say.

A cursory search seems to say that typical regrowth of a nail takes 4-6 months, but Spievak claimed his only took 4 weeks.

Can we say definitively that his "pixie dust" had nothing to do with it? I don't think so. Can we say it did have something to do with it? Also unknown... but the answer right now IMO certainly isn't a scientific "no."

Re: The ability to regrow body parts is dormant in mammals, not lost

#17

The trick is to make regeneration fast enough to heal the wound without making fast enough to cause cancer. Maybe even supported by provisional fibrosis.

Does that mean zebra fish with their ability to regrow the retina get cancer at a higher rate?

Re: The ability to regrow body parts is dormant in mammals, not lost

#18
post #9

Earlier quoted context omitted.

Lol, I once sharpened my knives and went to cook. During the prep I said, "wow I wonder how sharp the knife is", next thing you know, i cut about 1/4" of my finger tip off, right through the finger nail with zero resistance. Besides the blood getting everywhere and needing superglue to stop it, it grew back completely fine.

[flagged]

Irony deficiency

Re: The ability to regrow body parts is dormant in mammals, not lost

#19

I’m surprised this does not mention humans can grow back the tips of their fingers (past the white part of cuticle) https://www.npr.org/sections/health-shots/2013/06/10/1903854... Supposed to be only kids but I’ve chopped off a few mm by accident it came back as an adult or I can’t tell the difference.

The exact same thing happened to me. I chopped off a good half a cm with an axe when splitting firewood about 5 years ago. After no less than 6 months there wasn’t any sign of the mutilation.

Re: The ability to regrow body parts is dormant in mammals, not lost

#20

I’m surprised this does not mention humans can grow back the tips of their fingers (past the white part of cuticle) https://www.npr.org/sections/health-shots/2013/06/10/1903854... Supposed to be only kids but I’ve chopped off a few mm by accident it came back as an adult or I can’t tell the difference.

Does your fingerprint look normal? When I was a kid I was goofing around with a pair of scissors and lopped off a good chunk of the pad of one finger. Thirty years later my fingerprint looks like a bunch of little dots at that location. The ridges never grew back properly.
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