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Improvement in advanced Alzheimer’s disease following high-dose psilocybin

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Re: Improvement in advanced Alzheimer’s disease following high-dose psilocybin

#101
post #66

I was recently reading about a phenomenon called terminal lucidity, where a person suffering from mental decline such as Alzheimer's spontaneously improves, recognizing loved ones, retrieving memories, and being able to carry on conversations. It's called "terminal" because the person usually dies within hours or days. If this is a real phenomenon, then it's amazing to think that at least some of the people who suffe…

If you have cared for someone with dementia, this isn't so surprising.

It isn't a monotonic decline with memories disappearing forever. It is like wave upon wave of changing capacity at different time scales. The general trend is deterioration, but there are frequent periods that can almost seem like remission.

There is a well known daily cycle referred to as "sundowning", where the sufferer tends to come unraveled later in the day. The next morning, they'll be more functional.

Later in the progression, you can see much higher frequency variations. Like periods of disorientation and confusion interspersed with periods of lucidity all within a single sitting or conversation.

In those periods of greater lucidity, recall of the past can be more accurate. General listening comprehension, speaking, and logical thought also seem more normal.

Edit to add: I sometimes wonder if the belief in terminal lucidity is one of those logical fallacies which support lots of superstitions. Are we just fixating on the final wave in this chaotic wave train, and forgetting all the other waves that happened before it? Or is it that more caretakers are engaged and observing these waves towards the end, e.g. because the patient is known to be in the terminal phase..?

Re: Improvement in advanced Alzheimer’s disease following high-dose psilocybin

#102

Earlier quoted context omitted.

I certainly have been reckless with it, but it helped me a lot to cope with constant high stress without resorting to more immediately harmful things. It also gave me a lot of nice experiences, unique insight and other things like that. Before this dysfunction started, bad experiences were pretty rare rather than practically every time...

shame, same with mushrooms?

Cannot say the same for psilocybin. Far as I can tell, I majorly overdosed the first time, because I fainted, hit my head and had to go to the hospital for staples.

Around a week later I took the same dose again (the rest of what I had) to help process the trauma. (It did help. I of course avoided the situation that made me faint the first time)

I'd want to try psilocybin again sometime; it's quite a bit more expensive than LSD but it does have an interesting profile (for me: less stimulant-like)

Re: Improvement in advanced Alzheimer’s disease following high-dose psilocybin

#103
post #66

I was recently reading about a phenomenon called terminal lucidity, where a person suffering from mental decline such as Alzheimer's spontaneously improves, recognizing loved ones, retrieving memories, and being able to carry on conversations. It's called "terminal" because the person usually dies within hours or days. If this is a real phenomenon, then it's amazing to think that at least some of the people who suffe…

Same thing happens for other disease. Some kind of last honey moon period where your health improves and often followed by a catastrophic relapse. I'm nobody but it makes me feels there's an economic system issue, the body gradually degrades but has the ability one last time to inject a final wave of change to try restore a proper state but the resources are too short and so the attempt cannot sustain itself. I wonde…

I’ve heard this is because a lot of symptoms are not from the disease itself but actually side effects of mounting an aggressive immune system response to the underlying condition. Once your body gives up the fight as a lost cause, you will get a burst of relief and restored function from the lack of immune activity but it happens just before total system collapse.

Re: Improvement in advanced Alzheimer’s disease following high-dose psilocybin

#104
post #96

Earlier quoted context omitted.

>>the government had a hysterical fit and completely banned it because people who took it were more likely to oppose the Vietnam War. If you are to believe the Brave New World ( https://en.wikipedia.org/wiki/Brave_New_World ) worldview of Huxley (who topically was on loads of LSD himself), you'd think the government would want to flood the public with psychedelics -- low to zero toxicity, allows people to zone out, n…

hallucinogens where taken by hippies, it was probably a way to put a few extra commies and lefties in prison

Yes, I think half of the politicians nowadays run on cocaine, no busts on TV.

Re: Improvement in advanced Alzheimer’s disease following high-dose psilocybin

#105
post #54

Earlier quoted context omitted.

Yup. Not sure which particular stopped-clock struck right within the generally anti-science MAHA movement but I think everybody is happy to take the win.

Ironically enough, the psychedelic field sort of defies some scientific analysis, so could be construed as "anti-science". I've seen some commentary that it's difficult to test. As an example, you can't really do a double blind study with a placebo because it's obvious to everybody who got the drug.

Double blind studies became a requirement in order to protect the people from the greed of pharmaceutica companies and their natural desire to cut corners in research.

Re: Improvement in advanced Alzheimer’s disease following high-dose psilocybin

#106

Highly editorialized title. "Transient multidomain functional improvement in advanced Alzheimer’s disease following high-dose psilocybin-containing mushroom administration: a case report" This is exactly that. A case report. This is not a successful treatment. Far short of that.

[deleted]

Re: Improvement in advanced Alzheimer’s disease following high-dose psilocybin

#107

Highly editorialized title. "Transient multidomain functional improvement in advanced Alzheimer’s disease following high-dose psilocybin-containing mushroom administration: a case report" This is exactly that. A case report. This is not a successful treatment. Far short of that.

[deleted]

Re: Improvement in advanced Alzheimer’s disease following high-dose psilocybin

#110

Earlier quoted context omitted.

When you take it, you understand, that if taken with the right approach it can lead to profound insights in changing your life and the effects described: helping with depression, addiction and accepting death are not far fetched at all. Yet it can also, if not guided or done on someone with anxiety have the opposite effect. The more biological effects I agreed are not conclusion that can be drawn from that.

Right, when you take it, it becomes clear it just injects salience / profundity / meaning into whatever you happen to be focused on or have on your mind (EDIT: mostly this is the main effect, but there can be novel perspectives / insights, and other audio-visual changes, but IMO it is the felt meaning that primarily drives the more credulous claims). Without adequate preparation, this is likely to be worthless in mos…

> However, not all causes of depression or addiction are about accepting death, or a salience / meaning problem, and even when that kind of issue is involved, a momentary experience of profound meaning is NOT actually necessarily transformative either (i.e. you can and in fact must still choose how to interpret that experience, once out of it).

I don't think it's (just) encountering the profound that ends addiction, I think it really just alters or "resets" your brain structure. I know somebody who had bit their nails for their entire life well into their 30's and after a mega dose of mushrooms they just stopped. It wasn't a shift in perspective, they just didn't have that habit anymore, or even the thought of it. They didn't even notice they stopped biting their nails until they had trouble typing.

It also seems to alleviate nerve pain, and apparently enabled one man paralyzed below the waist to walk again. Something really fundamental is getting altered.

Relevant:

https://www.theguardian.com/science/2026/may/05/magic-mushro...

Also

https://www.outsideonline.com/outdoor-adventure/exploration-...

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