Improvement in advanced Alzheimer’s disease following high-dose psilocybin
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Re: Improvement in advanced Alzheimer’s disease following high-dose psilocybin
#2[flagged]
Re: Improvement in advanced Alzheimer’s disease following high-dose psilocybin
#3Good riddance - this kind of thing needs to be experimented with more. But 5 grams! This reads like witch doctor science; I’m surprised it passed ethics
Re: Improvement in advanced Alzheimer’s disease following high-dose psilocybin
#4Not quite a "successful treatment":
> This case documents transient multidomain functional improvement in advanced Alzheimer’s disease following psilocybin administration. The findings do not imply disease reversal but suggest that residual functional capacity may persist in late-stage neurodegeneration and may become transiently accessible under specific neuromodulatory conditions.
Very interesting nonetheless.
> One month after the initial session, the patient remained continent and functionally improved compared with baseline. A second supervised psilocybin session using 3 g was subsequently performed and was associated with greater verbal expressivity, improved facial mimicry, spontaneous humor, emotionally valenced autobiographical imagery, and increased agility while walking.
> The patient spontaneously stated: “It is pleasant to come here.
This is just wonderful.
Re: Improvement in advanced Alzheimer’s disease following high-dose psilocybin
#5Good riddance - this kind of thing needs to be experimented with more. But 5 grams! This reads like witch doctor science; I’m surprised it passed ethics
The Johns Hopkins studies have been administering high doses for 20+ years now. The difference is that they use synthesized psilocybin instead of mushrooms (which makes the dosing more consistent since potency can vary a lot across strains and individual mushrooms).
Re: Improvement in advanced Alzheimer’s disease following high-dose psilocybin
#6> n=1
> pay to publish journal
> no clear Alzheimers diagnosis ("[...] were considered clinically most compatible with advanced Alzheimer’s disease")
> administration of a heroic dose of street-quality drugs vs. a controlled sample
> no university or hospital affiliation?
Extraordinary claims require extraordinary evidence, hence I remain skeptical
Re: Improvement in advanced Alzheimer’s disease following high-dose psilocybin
#7Good riddance - this kind of thing needs to be experimented with more. But 5 grams! This reads like witch doctor science; I’m surprised it passed ethics
While it’s a fairly good sized dose, it’s not one that would typically produce a nightmare trip scenario.
As far as ethics go, I would absolutely sign a document that gives the right for experimentation in the event I become incapacitated to some degree.
Re: Improvement in advanced Alzheimer’s disease following high-dose psilocybin
#8> n=1 > pay to publish journal > no clear Alzheimers diagnosis ("[...] were considered clinically most compatible with advanced Alzheimer’s disease") > administration of a heroic dose of street-quality drugs vs. a controlled sample > no university or hospital affiliation? Extraordinary claims require extraordinary evidence, hence I remain skeptical
That's fair, but research into psychoactive substances remains difficult due to legal constraints; N=1 but it will have piqued interest by others, they may want to repeat the tests on a larger scale.
That, or individuals will science on the ones they care for. I for one would write something like that down if I were to start developing dementia/alzheimers.
Re: Improvement in advanced Alzheimer’s disease following high-dose psilocybin
#9This exact case study came up on a recent Rogan episode with Dean Radin, PhD. While the result is very interesting and perhaps illuminating about the unexpected biological mechanisms, apparently the effects were very short lived.
Even more interesting, Dr. Radin discussed one of his companies is working on a new drug that uses the same brain receptors as psilocybin, that has the potential to induce similar effects (with no psychedelic side effects) with a nasal delivery system that crosses directly into the brain. The benefit of that, he says, is the effect would last for much longer, months perhaps, and patients would only have to take it a few times per year.
Re: Improvement in advanced Alzheimer’s disease following high-dose psilocybin
#10Good riddance - this kind of thing needs to be experimented with more. But 5 grams! This reads like witch doctor science; I’m surprised it passed ethics
While it’s a fairly good sized dose, it’s not one that would typically produce a nightmare trip scenario. As far as ethics go, I would absolutely sign a document that gives the right for experimentation in the event I become incapacitated to some degree.
I wouldn't, or put constraints into it - you may be incapacitated but you may also still be aware, and you wouldn't want to get I-have-no-mouth'd.