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Making Claude a Chemist

anthropic.com

71–80 of 97 posts

Re: Making Claude a Chemist

#71

Earlier quoted context omitted.

Without international treaty and regulation restricting frontier capabilities globally, any attempt to outlaw open source models will only be as effective as King Canute ordering the tide to turn. Unless the USA fancies bombing those who refuse.

China is definitely refusing. And definitely will bomb back.

[deleted]

Re: Making Claude a Chemist

#73
post #21

If they succeed here, won't they have to gate access to this feature, too? For the same reasons as, "if I so much as mention mitochondria, it downgrades me to Opus." Step 1. Make it so Claude can do anything — the whole point of AGI Step 2. Wait, if the user can do Anything, that would be Very Bad! Step 3. Err on the safe side with blanket bans of entire fields The latter actually seems to me a sensible reaction to e…

Maybe? It seems like their strategy is to accept that safety is imperfect, err on the side of over-triggering, and iterate.

I don’t think it’s a black and white “if fable 5 over triggers on bio safety in 2026, that’s the final pattern we should expect to see from post-Mythos 20 in 2036”

Re: Making Claude a Chemist

#74
post #20

Earlier quoted context omitted.

> Feels complex like solving a Rubik's cube to write down synthesis steps but it is all a sequence of memorized tricks. Do Cannizaro if you want this, Bergmann to do that. I remember two years ago, when I actually got into using graph data structures, wondering if maybe the "space" of available reactions for any given starter and target molecules could be mapped as a graph, with intermediates as nodes and reactions a…

There is a lot of graph theory in Chemistry - modelling chemicals as (vertex/edge coloured) graphs, reaction networks, etc. Of course some molecules (eg aromatic systems, like ferrocene) are not naturally representable as graphs. I wonder if it is the same with synthesis - are there reactions hard to model as a graph (or petri net or whatever). One simple example I know is that you have to be careful with including a…

Why is ferrocene ungraphable or in this context unable to be modelled in that way?

Re: Making Claude a Chemist

#75
post #21

If they succeed here, won't they have to gate access to this feature, too? For the same reasons as, "if I so much as mention mitochondria, it downgrades me to Opus." Step 1. Make it so Claude can do anything — the whole point of AGI Step 2. Wait, if the user can do Anything, that would be Very Bad! Step 3. Err on the safe side with blanket bans of entire fields The latter actually seems to me a sensible reaction to e…

I think one time I asked opus about copyfail when it just came out and it did treat me like some sort of criminal, but are there really people that run into this on a regular basis other than cybersecurity experts (which cannot be a big enough group to generate all of this criticism)?

I have been trying to work on debugging tools using Opus 4.8. As it turns out working with low-level techniques that inspects and alters behavior of other processes is bordering close enough to cybersecurity research that it often hits the guardrails.

Re: Making Claude a Chemist

#77

Earlier quoted context omitted.

I just wait until a Opensource model inhaled all the chemistry books and papers. Lol. They are following closely and the best offer 80-90% of the performance and come with a very small fraction of the costs.

Why wouldn't the US gov. outlaw the open source models?

It cannot. The only available law is an export control law. A restriction on an open model would be strongly unconstitutional due to a freedom of speech guarantee in the Constitution.

Re: Making Claude a Chemist

#78
post #21

If they succeed here, won't they have to gate access to this feature, too? For the same reasons as, "if I so much as mention mitochondria, it downgrades me to Opus." Step 1. Make it so Claude can do anything — the whole point of AGI Step 2. Wait, if the user can do Anything, that would be Very Bad! Step 3. Err on the safe side with blanket bans of entire fields The latter actually seems to me a sensible reaction to e…

It would make more sense to have specialized versions of Claude instead of having a universal one ie BioClaude, ProgrammerClaude, NuclearClaude, CyberSecurityClaude, et al This would be both safer and less annoying to use.

That seems bad because it kills interdisciplinary science.

Re: Making Claude a Chemist

#79

Earlier quoted context omitted.

There is a lot of graph theory in Chemistry - modelling chemicals as (vertex/edge coloured) graphs, reaction networks, etc. Of course some molecules (eg aromatic systems, like ferrocene) are not naturally representable as graphs. I wonder if it is the same with synthesis - are there reactions hard to model as a graph (or petri net or whatever). One simple example I know is that you have to be careful with including a…

Why is ferrocene ungraphable or in this context unable to be modelled in that way?

I meant metallocenes in general:

https://en.wikipedia.org/wiki/Metallocene

A metal atom sandwiched between two Cp rings. You _can_ model this as 5 single bonds between each atom of a ring (so 10 total C-M bonds), or you have to have some kind of 'edge' (bond) between the ring as a whole and the metal.

The more general issue is that a graph model of a chemical assumes a 'bond' is between exactly two atoms. Three-center hydrogen bonds are another example where this model fails to capture the chemistry very well.

Of course, it's a tradeoff - you can model _most_ compounds with just graphs (plus atom type, charge, chirality) and the relatively few that do not quite fit are special cases.

Re: Making Claude a Chemist

#80
post #63
post #21

If they succeed here, won't they have to gate access to this feature, too? For the same reasons as, "if I so much as mention mitochondria, it downgrades me to Opus." Step 1. Make it so Claude can do anything — the whole point of AGI Step 2. Wait, if the user can do Anything, that would be Very Bad! Step 3. Err on the safe side with blanket bans of entire fields The latter actually seems to me a sensible reaction to e…

"Making Claude a chemist" is a punch in the face of all us here after we got a taste of Claude fable blocking almost any STEM-related topic. So i don't know what Story Anthropic wants to tell us with this blog. Probably more like "Hey, look at what awesome tricks Claude can do which of course you will never experience because you're not american, not friends with the CEO, not rich or simply because fuck you"

I think the story they want to tell is "we're not just taking your jobs, we can do positive stuff like Chemistry too, just like DeepMind!"

Except of course they mostly can't because Chemistry is about structure and molecular dynamics, not people's descriptions of experiments.

DeepMind if so far the only AI/AGI company - the rest are LLM companies.

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