New pancreatic cancer drug might open the door to much longer survival times
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Re: New pancreatic cancer drug might open the door to much longer survival times
#2Re: New pancreatic cancer drug might open the door to much longer survival times
#3[flagged]
Re: New pancreatic cancer drug might open the door to much longer survival times
#4The study this article references is here: https://clinicaltrials.gov/study/NCT06625320
Re: New pancreatic cancer drug might open the door to much longer survival times
#5The relevant line is:
"oncologists went wild over the results of a drug called daraxonrasib."
Re: New pancreatic cancer drug might open the door to much longer survival times
#6As is often the case, the title is hyperbolic. The discovery applies to 20% of tumors, and "one of cancer's significant defenses" or "a key weakness of cancer" would be more accurate.
That said, I'll happily take "we discovered a key weakness in 20% of cancers," please and thank you.
Re: New pancreatic cancer drug might open the door to much longer survival times
#7As is often the case, the title is hyperbolic. The discovery applies to 20% of tumors, and "one of cancer's significant defenses" or "a key weakness of cancer" would be more accurate. That said, I'll happily take "we discovered a key weakness in 20% of cancers," please and thank you.
What does this mean in layman's terms? How will this potentially help me if I get cancer?
Re: New pancreatic cancer drug might open the door to much longer survival times
#8As is often the case, the title is hyperbolic. The discovery applies to 20% of tumors, and "one of cancer's significant defenses" or "a key weakness of cancer" would be more accurate. That said, I'll happily take "we discovered a key weakness in 20% of cancers," please and thank you.
What does this mean in layman's terms? How will this potentially help me if I get cancer?
One of the many therapies that are being developed so that you can survive longer even with the most lethal tumours.
Re: New pancreatic cancer drug might open the door to much longer survival times
#9I’m surprised Michael Levin’s research hasn’t expanded much beyond a certain YouTube media bubble. They’re able to start and stop cancer growth with only voltage changes between cells, likewise they can also trigger regeneration or anatomical changes using voltage changes. His research seems to suggest a lot of important anatomical plans are stored in an electric field around the body, not in the DNA. This model’s explanation for cancer is that some cells become disconnected from this field and start growing independently of the overall body plan.
Re: New pancreatic cancer drug might open the door to much longer survival times
#10As is often the case, the title is hyperbolic. The discovery applies to 20% of tumors, and "one of cancer's significant defenses" or "a key weakness of cancer" would be more accurate. That said, I'll happily take "we discovered a key weakness in 20% of cancers," please and thank you.
What does this mean in layman's terms? How will this potentially help me if I get cancer?
Cancer is not one thing, it's a huge zoo of many many many ways that cells start to break the social contract and divide in an uncontrolled manner.
One of the most commonly observed broken mechanisms is mutation in the gene KRAS that turns this on/off growth switch into the permanently on position.
This has been known for decades, of course. And there have been huge amounts of effort to try to develop drugs that target KRAS in cancer, but for decades it's always been thought of as 'undruggable' because of the difficulty of finding any molecules that would affect it.
This new drug, that finally treats KRAS mutated cancers, goes about it in a new way. Instead of trying to gum up the works of a single protein by sticking a small chemical in it, it effectively "glues" the KRAS protein to another protein, CypA, which keeps the switch away from reaching the normal areas where it's "on switch" activity works.
So this new drug means two things: 1) a lot of the most difficult to treat cancers are now far more treatable, and in the next 1-5 years clinical trials will tell us which cancers this particular drug works well for, 2) there's an entire new class of drug activity that everybody is chasing at this very moment, so in 5-25 years we'll likely have a huge number more of these sorts of treatments.