541–550 of 1001 posts
I've spent enough time with this now in Claude Code (and Claude.ai and Claude Code for web) to have an opinion on Fable 5: it's a beast. I'm throwing some VERY difficult problems at at - things I've been dragging my heels on for months - and it's crunching through them very happily. One that I'm willing to share (albeit from just a week ago) - I built a Python library last week that bundles MicroPython compiled to WA…
Pelican for Fable 5 on default settings is a clear improvement on Opus 4.8 Fable 5 default: https://gist.github.com/simonw/036bee5a703e7ec84e34efa974438... Opus 4.8 (the "max" one is closest to Fable): https://simonwillison.net/2026/May/28/claude-opus-4-8/#and-s... Now here are the Fable pelicans for all five of the thinking effort levels - low, medium, high, xhigh, max: https://tools.simonwillison.net/markdown-svg-r…
> Drug design: Using Mythos 5, our internal protein design experts accelerated aspects of the drug design process by around ten times. In one example, they found that Mythos 5, with protein design and bioinformatics tools but no human assistance, matches or beats skilled human operators. In doing so, the model executes all of the tasks that are normally completed by a scientist: choosing binding sites, selecting and…
The rate limiting steps are generally testing, or characterizing. Not designing protein binders.
Impressions from testing Fable 5 prior to launch: • My most noticeable immediate jump was in how its frontend design was much more intentionally crafted, and delightful without feeling like 'AI vibe coded'; with better end-user usability too. • In some internal agentic harnesses, it achieved better results with about half the tokens, making it cost the ~same as Opus 4.8 price-wise! The real price increase is less tha…
I just ran it on a tough reverse engineering problem I'm having that neither Claude Code 4.8 or ChatGPT Codex 5.5 could figure out. 30 minutes later Fable has it all figured out perfectly.
It seems like Fable will refuse to do any work when it comes to developing LLMs or even asking questions about topics related to LLM. Simple things like asking to explain a paper fails! From the model card: In light of the ability of recent models to accelerate their own development, we've implemented new interventions that limit Claude's effectiveness for requests targeting frontier LLM development (for example, on…