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Vitamin D3 During Pregnancy and Cognitive Performance at 10 Years

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Re: Vitamin D3 During Pregnancy and Cognitive Performance at 10 Years

#61

Post by wrsh07 »

dheera wrote: post #54
filoleg wrote: post #47

Earlier quoted context omitted.

The grandparent explained exactly why it is an issue though. It isn't because US is somehow just magically more legitimate than Denmark. As they stated, it is because the population of Denmark is very homogenous, as opposed to the US. If you are trying to make a generalization that applies to a range beyond just white people, having Denmark as your sole sample is clearly flawed. Along the same lines, picking Japan fo…

I don't think it invalidates a study as long as you do things on relative terms and have a control group. Another study can see if the same delta effect is reproducible in an e.g. homogeneous Asian population and report on it. It is probably a logistical nightmare to do a study of this sort in multiple countries and regulatory systems simultaneously.

It doesn't invalidate the study at all! On the contrary, if you're measuring vitamin d levels from blood tests, it is easy to adjust the dosage to match.

It's just an important factor - if you live much further south or spend a lot of time outdoors, your target dosage will be different than someone in _Denmark_.

Re: Vitamin D3 During Pregnancy and Cognitive Performance at 10 Years

#62

Post by Scroll_Swe »

niteshpant wrote: post #23

I have thoughts on this 1. Yes, vitamin D actually controls a lot of bodily functions it’s very easily set aside as not a “main” factor when in reality it actually controls a lot 2. This study was done on women in Denmark only which isn’t a great study subject considering Denmark doesn’t get a lot of sun to begin with so most of these women would already start at very low levels 3. This doesn’t directly correlate to…

2. Good for me as I live in Sweden. Started only in my 30s to take Vitamin D and multivitamin. My 20s where wasted really. I studied and worked but felt even more shit. Less shit now I guess.

Re: Vitamin D3 During Pregnancy and Cognitive Performance at 10 Years

#63

Post by cortic »

Vitamin D excess can lower blood levels of vitamin K2, reducing bone development. Not sure if the levels would be high enough for this (difficult to find safe numbers for in utero), but the side effects, joint pains, stiffness, could have motivated the kids to stay indoors and focus on more intellectual pursuits, leading to better cognitive performance.

I point this out because there are so many known factors both positive and negative that contribute to increased 'cognitive performance' it is impossible to account for all of them, even within a randomized trail such as this. People are weak to assumptions when it comes to correlation.

Re: Vitamin D3 During Pregnancy and Cognitive Performance at 10 Years

#65

Post by margalabargala »

Aurornis wrote: post #59

> We found that high-dose supplementation was positively associated with 3 of 11 functions assessed: verbal memory, visual memory, and flexibility or set shift. However, the association with flexibility or set shift was not significant after correction for multiple testing. They tested 11 different measures. Only 3 of those tests showed significance, but after they corrected for multiple testing the significance of 2…

Relevant xkcd

https://xkcd.com/882/

Re: Vitamin D3 During Pregnancy and Cognitive Performance at 10 Years

#66

Post by HexPhantom »

niteshpant wrote: post #23

I have thoughts on this 1. Yes, vitamin D actually controls a lot of bodily functions it’s very easily set aside as not a “main” factor when in reality it actually controls a lot 2. This study was done on women in Denmark only which isn’t a great study subject considering Denmark doesn’t get a lot of sun to begin with so most of these women would already start at very low levels 3. This doesn’t directly correlate to…

Women in the study weren't all starting from very low vitamin D levels

Re: Vitamin D3 During Pregnancy and Cognitive Performance at 10 Years

#67

Post by HexPhantom »

tarkin2 wrote: post #24

I'm perhaps missing something but if there were a significant connection, wouldn't this mean those in sunnier climates would have better verbal and visual memory? If there were a connection then I would wager that there are more significant factors, since I have seen or heard of no evidence to assume those in sunnier climates have better verbal and visual memory. The results of this study seem to show no significant…

The paper isn't saying vitamin D determines cognition in general, just that there was a modest signal in a couple of memory measures

Re: Vitamin D3 During Pregnancy and Cognitive Performance at 10 Years

#68

Post by HexPhantom »

pkoird wrote: post #2

I'm not sure if there are any research showcasing the effects humanity has had in general due to low sun exposure. From all the benefits of Vitamin D and the recent human behavorial shift leading to low sun exposure (car travel, air conditioning, sunscreens even), there are bound to be new biological or psychological changes humanity is experiencing for the first time.

What I find more plausible is that low sun exposure is one small contributor among many

Re: Vitamin D3 During Pregnancy and Cognitive Performance at 10 Years

#69

Post by HexPhantom »

api wrote: post #21
pkoird wrote: post #2

I'm not sure if there are any research showcasing the effects humanity has had in general due to low sun exposure. From all the benefits of Vitamin D and the recent human behavorial shift leading to low sun exposure (car travel, air conditioning, sunscreens even), there are bound to be new biological or psychological changes humanity is experiencing for the first time.

I've wondered for a while if the apparently higher cognitive performance and resulting societal wealth at higher latitudes might be some kind of second order side effect from long-term selection for lower sun exposure. We already know this vitamin D is almost certainly why Northern peoples evolved lighter skin. (I realize this is a frought topic, so please hold the race science bullcrap replies or the over-reactions…

The vitamin D angle seems much more plausible to me as a public-health issue than as an explanation for broad population-level cognitive differences

Re: Vitamin D3 During Pregnancy and Cognitive Performance at 10 Years

#70

Post by letmevoteplease »

Aurornis wrote: post #59

> We found that high-dose supplementation was positively associated with 3 of 11 functions assessed: verbal memory, visual memory, and flexibility or set shift. However, the association with flexibility or set shift was not significant after correction for multiple testing. They tested 11 different measures. Only 3 of those tests showed significance, but after they corrected for multiple testing the significance of 2…

Where are you getting "after they corrected for multiple testing the significance of 2 of those disappeared"? The text you quoted says, of the three, one disappeared and two remained.
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