Biohub releases a world model of protein biology
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Re: Biohub releases a world model of protein biology
#2we interviewed Alex Rives, cofounder of EvoScale and Head of Science at BioHub - here https://www.latent.space/p/esmfold2
also 3 paper coauthors walked thru it with us: https://youtu.be/4g1bURdKN0Q
all this is part of the new AI for Science effort we are spinning up at Latent Space - all guidance and support would be greatly appreciated as this is a much harder domain to cover than software
Re: Biohub releases a world model of protein biology
#3It's interesting that there are almost no comments on this. This feels like some of the most exciting and impactful fields of the next years. I worked with a cracked researcher that was generating molecules a couple of years ago. She spent most of her time fighting cuda bugs and trying installing packages. I wonder if the ecosystem matured right now. There are people studying cells to see what enters and what exits and engineer how to stop, for example, resources feeding a bad cell. Possibilities feel endless. I am a little worried about side effects, since bio is way more chaotic than silicon, but hopefully AI will help with that level of chaos too.
Re: Biohub releases a world model of protein biology
#4It's interesting that there are almost no comments on this. This feels like some of the most exciting and impactful fields of the next years. I worked with a cracked researcher that was generating molecules a couple of years ago. She spent most of her time fighting cuda bugs and trying installing packages. I wonder if the ecosystem matured right now. There are people studying cells to see what enters and what exits a…
Quite frankly, most people on HN are software devs with a wider interest in the world. HN’ers usually-ish comment when they have something insightful to sat, even if the insight is just a humble one.
But I dare to guess that most HN’ers did high school bio and that’s it, so it’s harder to even give a small thoughtful comment on it, so they refrain.
Case in point, I wouldn’t have commented either. But I feel at home here and notice some behavioral patterns. And compared to other fellow devs, I generally am more tuned to tune in on behavioral patterns because of having studied psychology.
But that’s just my take.
Re: Biohub releases a world model of protein biology
#5A similar work is Foundry (https://github.com/RosettaCommons/foundry). While both of them are good, the main issue is that it is not accurate enough at atom level. There are good chances that predicted or designed active site is slightly different from the real structure solved by X-ray, NMR or cryo-electronic microscopy. A side-chain or two may turn the other way so that it changes how the interaction is interpreted. So the tools are good and convenient now. But the design or prediction is often hit-and-miss.
Re: Biohub releases a world model of protein biology
#6 a scientific engine for prediction, design, and discovery that can map proteins across the tree of life, predict their structures, and design new protein binders that function in laboratory experiments.
Re: Biohub releases a world model of protein biology
#7It's interesting that there are almost no comments on this. This feels like some of the most exciting and impactful fields of the next years. I worked with a cracked researcher that was generating molecules a couple of years ago. She spent most of her time fighting cuda bugs and trying installing packages. I wonder if the ecosystem matured right now. There are people studying cells to see what enters and what exits a…
I'm sure people will take this the wrong way, but a lot of the people who are on HN and who orbit technology circles in SF are really just not actually intellectually curious people.
They might like to think they are, they might try to pretend they are, but when pushed they're simply not.
Look at all of the groupthink that is perpetuated nonstop while they also proclaim they're creating, investing in, etc. so many unique ideas. Yet year after year it's the same thing in a different color.
What they actually are is interested in money and prestige. So give it a little time and they'll learn enough about biology to try and get some validation from their peers with comments. If money actually pours into bio that is.
Re: Biohub releases a world model of protein biology
#8Incredible, but also scary if you think about what it may be lowering the barrier of entry to…
Re: Biohub releases a world model of protein biology
#9Our mission is to cure or prevent all disease
Okay, now you have my attention.
What's the deal on the company behind it? “Biohub is a 501(c)(3) biomedical research organization...” Nonprofit. Nifty!
This all sounds great, but as we have recently seen with, say OpenAI, there is nonprofit and then there is nonprofit. Anyone know which Biohub is?
Re: Biohub releases a world model of protein biology
#10> This model is released under the MIT License.
Huh, appears to be actually open source, that's a pleasant surprise. Usually these academic models have some weird license attached to them.