21–30 of 62 posts
I hope they can get this to people quickly. Someone I love has been diagnosed with stage 3 end of Feb this year and it's utter hell. For everyone, not just the patient.
Earlier quoted context omitted.
> The company says that the drug was generally well tolerated, but that’s on the oncology scale. > ... > He’s been on daraxonrasib since early this year, and describes it this way: “. . .it’s a nasty drug. It causes crazy stuff like my body can’t grow skin and so I bleed all out of a whole bunch of parts of me that shouldn’t be bleeding” If you go to that link above, be prepared, because he also looks like he’s had a…
I am in the enviable position to not be actively dying from an untreatable disease, so obviously haven’t seen things from the other side of this sort of situation. But to me, that doesn’t sound like a life worth living. Obviously different people will have different thresholds for when to throw in the towel, and I’m glad that we are finding medicines to allow people to make the choices that align with their own drive…
I am in a position to be intimately familiar with illness. I will say that health is a spectrum and the mind is incredibly resilient. You will surprise yourself as you inevitably age how much your mind will adapt to always hurting. There is more to life than body discomfort. This patient sounds like he has his faculties and is making an informed decision to continue living, because his life is worth the discomfort he is going through. I am reminded of a line along the lines of every day you experience, no matter how terrible, is very likely a day that someone else yesterday would have desperately wanted.
Earlier quoted context omitted.
> The company says that the drug was generally well tolerated, but that’s on the oncology scale. > ... > He’s been on daraxonrasib since early this year, and describes it this way: “. . .it’s a nasty drug. It causes crazy stuff like my body can’t grow skin and so I bleed all out of a whole bunch of parts of me that shouldn’t be bleeding” If you go to that link above, be prepared, because he also looks like he’s had a…
I am in the enviable position to not be actively dying from an untreatable disease, so obviously haven’t seen things from the other side of this sort of situation. But to me, that doesn’t sound like a life worth living. Obviously different people will have different thresholds for when to throw in the towel, and I’m glad that we are finding medicines to allow people to make the choices that align with their own drive…
I often think about this, wondering how many of those animals would have chosen death if given the choice, and how often it is simply a way to spare the owner from seeing something that upsets them.
I hope they can get this to people quickly. Someone I love has been diagnosed with stage 3 end of Feb this year and it's utter hell. For everyone, not just the patient.
Of course this is better than nothing, but it is not a cure.
Moreover, the link provided by another poster to an article that discusses the side effects, shows that they are unpleasant.
Still, an extra year of life may provide a chance to survive until the appearance of a better solution.
I hope they can get this to people quickly. Someone I love has been diagnosed with stage 3 end of Feb this year and it's utter hell. For everyone, not just the patient.
Unfortunately, it seems that this just provides an extra year of life or so. Of course this is better than nothing, but it is not a cure. Moreover, the link provided by another poster to an article that discusses the side effects, shows that they are unpleasant. Still, an extra year of life may provide a chance to survive until the appearance of a better solution.
"survival" is the wrong word; its terminal. honestly the drugs and chemo and treatments they put pancreatic patients through for possibly a few more (not very nice) weeks is almost criminal. a good doctor will tell you to go make the most of those 3 months post diagnosis. that said its nice to see progress against one of the worst cancers out there and i hope it leads to genuine breakthroughs. but this drug is nothin…
> "survival" is the wrong word; its terminal. No one actually knows that one way or the other since some patients were still taking it after the study ended according to the article.
One group had median values of 8.5 months for progression-free survival and 13.1 months for overall survival.
The other group had median values of 8.1 months for progression-free survival and 15.6 months for overall survival.
Overall Survival (OS) measures the time until death from any cause.
Progression-Free Survival (PFS) evaluates how long a treatment can delay disease progression or death.
So at least most of the patients from the study have died, because otherwise median values could not have been computed.
Thus the treatment had provided them a median life extension of about 3/4 years. The lucky ones probably have got more than an extra year.
Earlier quoted context omitted.
> The company says that the drug was generally well tolerated, but that’s on the oncology scale. > ... > He’s been on daraxonrasib since early this year, and describes it this way: “. . .it’s a nasty drug. It causes crazy stuff like my body can’t grow skin and so I bleed all out of a whole bunch of parts of me that shouldn’t be bleeding” If you go to that link above, be prepared, because he also looks like he’s had a…
I am in the enviable position to not be actively dying from an untreatable disease, so obviously haven’t seen things from the other side of this sort of situation. But to me, that doesn’t sound like a life worth living. Obviously different people will have different thresholds for when to throw in the towel, and I’m glad that we are finding medicines to allow people to make the choices that align with their own drive…
BUT ... this is not a binary situation, where suddenly life becomes unbearable. There's so much worth living for. And not just the obvious big things in life (kids, family, friends), but also many many small things. Man, that first cup of cappuchino once the effects of chemo wear off alone is almost worth all the puking beforehand :) Or having a nice piece of cheese. Seeing my small herb garden grow. Etc. etc.
The trick is to live a peaceful, content life. Be grateful for what you have. Enjoy your short time on earth.
Earlier quoted context omitted.
I am in the enviable position to not be actively dying from an untreatable disease, so obviously haven’t seen things from the other side of this sort of situation. But to me, that doesn’t sound like a life worth living. Obviously different people will have different thresholds for when to throw in the towel, and I’m glad that we are finding medicines to allow people to make the choices that align with their own drive…
This may sound condescending but: you sound young, not disabled, and extremely sheltered from being exposed to disabled people. I am in a position to be intimately familiar with illness. I will say that health is a spectrum and the mind is incredibly resilient. You will surprise yourself as you inevitably age how much your mind will adapt to always hurting. There is more to life than body discomfort. This patient sou…
The founders of Lovable and Builder.ai individually received more funds than the whole group of the researchers behind this medicine...
That’s like talking about the ROI of a winning lottery ticket. We can’t know ahead of time which medicine works so you need to fund many teams at the beginning.
https://hardmanandco.com/research/corporate-research/2025-ph...>
Total VC tech investment in 2025 was $425 billion.
https://news.crunchbase.com/venture/funding-data-third-large...>