"The number of recent internet services that have grown from nothing to hundreds of millions of users is frankly rather astonishing – Pinterest, Instagram, Groupon, Zynga"

Ok.. and... who else? I wouldn't call a few handful or even 20-30 astonishing.

"Almost every possible internet distribution channel has MORE users than ever before – whether it be search, social, mobile, video, local, SMS, email, chat, etc."

And every channel has also been saturated with tons of competition. Search = millions of pages indexed everyday, and tons of old brands ranking before you. Social? Good luck getting your new content noticed when you have 0 followers.

"it’s certainly MUCH cheaper & faster to build product than ever before"

Cheaper and faster? When you have to build multiple products for iPhone, Android, Windows, and for: search, social, mobile, video, local, SMS, email, chat...

"that just means less competition for those of us ready to really dig in and invest at scale in all the millions of new “small” businesses that will emerge and dominate the globe in coming years."

It's not small vs. big. It's enterprise vs consumer internet. There are tons of small enterprise companies out there.