Scientists say they've reversed brain aging in mice with a nasal spray

2.2 Animals and Study Design The study comprised two cohorts of C57BL/6 mice: young adult (3 months old) and late middle-aged (18 months old). We chose 18 months old mice, as this mouse age is approximately equivalent to a 60-year-old human (Dutta and Sengupta 2016).

I posted paper above, DOI was linked at the end.

Re: Scientists say they've reversed brain aging in mice with a nasal spray

#6

Post by ddeck » Wed, May 27, 2026, 2:19 AM UTC

wizardforhire wrote: post #2

Was looking for the “in mice” in this article and found none… anybody got a link to the paper please

Intranasal Human NSC-Derived EVs Therapy Can Restrain Inflammatory Microglial Transcriptome, and NLRP3 and cGAS-STING Signalling, in Aged Hippocampus

https://isevjournals.onlinelibrary.wiley.com/doi/10.1002/jev...

Re: Scientists say they've reversed brain aging in mice with a nasal spray

#7

Post by instagib » Wed, May 27, 2026, 2:21 AM UTC

“While additional research is still needed before the treatment could be tested in humans, the study offers a striking possibility.”

(In mice)

Re: Scientists say they've reversed brain aging in mice with a nasal spray

#8

Post by Topgamer7 » Wed, May 27, 2026, 2:39 AM UTC

instagib wrote: post #7

“While additional research is still needed before the treatment could be tested in humans, the study offers a striking possibility.” (In mice)

Pinky and the brain can now sleep soundly as they age like wine

Re: Scientists say they've reversed brain aging in mice with a nasal spray

#9

Post by CoastalCoder » Wed, May 27, 2026, 2:39 AM UTC

Algernon for Flowers.

Re: Scientists say they've reversed brain aging in mice with a nasal spray

#10

Post by delichon » Wed, May 27, 2026, 2:41 AM UTC

I'm afraid of the result if we take someone wrapped in a comforting haze of dementia (I'm getting there) and force them into cold harsh reality. It may be as welcome a sobriety to an alcoholic. If the insurance stops paying does it become Flowers for Algernon?

We have several drugs that emulate dementia in various ways and call them recreational.