Live data from Hacker News

Not alive, but not dead: disembodied human brains used for drug testing

science.org

51–60 of 213 posts

Re: Not alive, but not dead: disembodied human brains used for drug testing

#51

Live dissection and experimentation on “alive but drugged” human brains is mental. How do you ensure that you aren’t torturing a brain that can’t see, hear or scream? How are you held accountable?

I’ll volunteer to waive my rights here. Feel free to do whatever you wish with my brain once it’s detached from my body :)

Can’t be worse than my organs being harvested for donation.

Re: Not alive, but not dead: disembodied human brains used for drug testing

#53

"alive" is not a meaningful term. It makes sense only when you have blunt instruments to measure aliveness, like pulse, respiration, heart beat, etc. Once you go much more granular, there's no particular spot to make a distinction between "alive" and "not alive", until you stop seeing any electrical, biochemical and mechanical activity of any kind, at which point you're basically saying "inert".

Is this dry humor and/or a deliberate attempt to make the reader even more horrified by the experiment? Or only a different sensibility from mine? No judgement. I just really can't tell.

Re: Not alive, but not dead: disembodied human brains used for drug testing

#54
post #27

Earlier quoted context omitted.

Well, we know how to make living brains insensate - that's who we all make it through surgery. Presumably they're doing something similar - or using some other well-understood mechanism - to ensure that's not the case. > The brains are already almost devoid of the coordinated neural firing necessary even for minimal consciousness, says Brendan Parent, a bioethicist at New York University Langone Health and one of six…

That’s somewhat overstated. We know anesthesia "works," and we know some of its molecular targets, but we do not fully know the mechanism by which it produces unconsciousness, ie whether anesthesia eliminates experience, or mainly blocks memory, report, and integrated neural processing.

Anesthesia appears to be a fairly broad effect - anaesthetics work on plants, for example [1], even though they lack any neural tissue whatsoever. It would be extremely surprising if those effects were also targeted enough to halt only some types of brain activity.

[1]: e.g. https://doi.org/10.4161/psb.27886

Re: Not alive, but not dead: disembodied human brains used for drug testing

#55
This is literally my biggest fear. The idea that my biology or consciousness could be keep alive and in a state of suffering for years, decades, centuries or longer via neural simulation or biological intervention.

I do wonder if AI advancements will allow me to see these horrors play out. Hopefully not to myself.

https://spikeartmagazine.com/articles/libra-season-hello-cru...

Re: Not alive, but not dead: disembodied human brains used for drug testing

#56

Live dissection and experimentation on “alive but drugged” human brains is mental. How do you ensure that you aren’t torturing a brain that can’t see, hear or scream? How are you held accountable?

It's still an open debate whether the seat of consciousness (or even simpler, perception) is the brain.

see e.g. Wahbeh, H., Radin, D., Cannard, C., & Delorme, A. (2022). What if consciousness is not an emergent property of the brain? Observational and empirical challenges to materialistic models. Frontiers in psychology, 13, 955594. https://doi.org/10.3389/fpsyg.2022.955594

https://en.wikipedia.org/wiki/Hard_problem_of_consciousness

Same for memory, which is "needed" as well for your question to make sense. The more current theories assume memories are stored not only in the brain, but throughout the body.

see e.g. Repetto, C., & Riva, G. (2023). The neuroscience of body memory: Recent findings and conceptual advances. EXCLI journal, 22, 191–206. https://doi.org/10.17179/excli2023-5877

https://en.wikipedia.org/wiki/Body_memory

Re: Not alive, but not dead: disembodied human brains used for drug testing

#57

Earlier quoted context omitted.

Between what he did to children, and what his parents did to him, it's hard to really blame the guy for having extreme sleep problems though.

> what he did to children The media and the people who bought into their shameless attention-grabbing lies are the reason he had sleep problems. He was unanimously acquitted of all counts, but the media made his life into a living hell by consistently portraying him as a pedophile because it drove incredible engagement numbers. A justice system should be "innocent until proven guilty", and yet MJ was deemed guilty ev…

I mean, he may have never done a sexual thing but his pedophilia was quite obvious and the degeneracy of parents to allow their children to spend the night in the bed of a grown man is not really good for society.

Re: Not alive, but not dead: disembodied human brains used for drug testing

#59
post #4

I just finished reading "That Hideous Strength" (CS Lewis) this weekend where they have a disembodied head kept "alive", and some convicts in the pipeline whose heads/brains, it is implied, will be experimented on similarly. Lewis was remarkably prophetic.

The Dust Theory in Permutation City by Greg Egan pushes the concept to bizarre levels.

Greg Egan is a legend

Re: Not alive, but not dead: disembodied human brains used for drug testing

#60

Live dissection and experimentation on “alive but drugged” human brains is mental. How do you ensure that you aren’t torturing a brain that can’t see, hear or scream? How are you held accountable?

When I had my ear surgery about 20 years ago, the doctor explained to me that I would be awake for part of the procedure, but the anesthesia meant that I would have no memory of it.¹ It’s a weird thing to think about whether that lack of memory would obviate the pain or discomfort of the moment.

1. As it turned out, I was so frightened in the lead-up to the surgery that they had to do general anesthesia on me because I was shaking too much for them to operate so I was unconscious for the whole thing.

Post reply on HN